Protein Alignment lab and en2a

DIOPT Version :10

• Sequence 1: NP_476613.1
• Gene: lab / 40817
• FlyBaseID: FBgn0002522
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_571119.2
• Gene: en2a / 30243
• ZFINID: ZDB-GENE-980526-167
• Length: 265
• Species: Danio rerio
• Alignment Length: 254
• Identity: 73/254 - (28%)
• Similarity: 97/254 - (38%)
• Gaps: 67/254 - (26%)

  Fly   333 AHQQHHQNSVSPNGGMNRQQRGGVISPGSSTSSSTSASNGAHPASTQSKSPNHSSSIPTYKWMQL 397
            |.:.|  |...|:.|    |.|..:.  :..:|:|..|:|...|..:|:.|
Zfish    70 ARENH--NPTGPSTG----QVGSTVP--AEEASTTHTSSGGKEAEIESEEP-------------- 112

  Fly   398 KRNVPKPQAPKLPASGIASMHDYQMNGQLDMCRGGGGGGSGVGNGPVGVGGNGSPGIGGVLSVQN 462
                .||:..                 .:|.|.|.....|...:       ||..|       |.
Zfish   113 ----LKPRGE-----------------NVDQCLGSESDSSQSNS-------NGQTG-------QG 142

  Fly   463 SLIMANSAAAAGSAHPNGMGVGLGSGSGLSSCSLSSNTNNSGRTNFTNKQLTELEKEFHFNRYLT 527
            .|..|.......|..|:.     |..|.......:|..:...||.||.:||..|:.||..|||||
Zfish   143 MLWPAWVYCTRYSDRPSS-----GPRSRKPKKKAASKEDKRPRTAFTAEQLQRLKAEFQTNRYLT 202

  Fly   528 RARRIEIANTLQLNETQVKIWFQNRRMKQKKR--VKEGL---IPADILTQHSTSVISEK 581
            ..||..:|..|.|||:|:||||||:|.|.||.  ||.||   :.|..|..|||:...:|
Zfish   203 EQRRQSLAQELGLNESQIKIWFQNKRAKIKKASGVKNGLAIHLMAQGLYNHSTTSKEDK 261

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lab	NP_476613.1	Homeodomain	505..558	CDD:459649	30/52 (58%)
en2a	NP_571119.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..30
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	65..142		23/128 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	155..180		5/29 (17%)
		Homeodomain	177..233	CDD:459649	30/55 (55%)
		Engrail_1_C_sig	234..264	CDD:431338	10/28 (36%)