DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lab and Hoxd3

DIOPT Version :9

Sequence 1:	NP_476613.1	Gene:	lab / 40817	FlyBaseID:	FBgn0002522	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_001257967.1	Gene:	Hoxd3 / 288152	RGDID:	1588601	Length:	432	Species:	Rattus norvegicus

Alignment Length:	511	Identity:	122/511 - (23%)
Similarity:	154/511 - (30%)	Gaps:	246/511 - (48%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 SYYESDSVHSYY----ATAAVATVAPPSNSSPITAANASATSNTQQQQQQAAIISSENGMMYTNL 211
            :|||:..:...|    ||.|.....|.....|..|||                          :|
  Rat    21 AYYENPGLFGGYGYSKATDAYGYSTPHQPYPPPAAAN--------------------------SL 59

  Fly   212 DCMYPTA----QAQAPVHGYAGQIEEKYAAVLHASYAPGMVLEDQDPMMQQATQSQMWHHQQHLA 272
            |..||::    |:.||:.                  ||.                   |....|.
  Rat    60 DSDYPSSACSIQSSAPLR------------------APA-------------------HKGAELN 87

  Fly   273 GSYALDAMDSLGMHAHMHHGLPHGHLGNLANNPHQQQPQVQQQQQQPHQQPQHPQNQSPAAHQQH 337
            ||.             |..|     .||........||.....:|||.|.|..|....|:
  Rat    88 GSC-------------MRPG-----TGNSQGGGGGNQPPGLNSEQQPPQPPPPPPTLPPS----- 129

  Fly   338 HQNSVSPNGGM-NRQQRGGVISPGSSTSSSTSASNGAHPASTQSKSPNHSSSIPTYKWMQLKRNV 401
              :..:|..|: .::.:||   |.:|:||||.:..                   .:.||:..|
  Rat   130 --SPTNPGSGVPAKKTKGG---PNASSSSSTISKQ-------------------IFPWMKESR-- 168

  Fly   402 PKPQAPKLPASGIASMHDYQMNGQLDMCRGGGGGGSGVGNGPVGVGGNGSPGIGGVLSVQNSLIM 466
                                                                       |||. .
  Rat   169 -----------------------------------------------------------QNSK-Q 173

  Fly   467 ANSAAAAGSAHPNGMGVGLGSGSGLSSCSLSSNTNNSGRTNFTNKQLTELEKEFHFNRYLTRARR 531
            .||.|.              ||......|.....:...||.:|:.||.||||||||||||.|.||
  Rat   174 KNSCAT--------------SGENCEDKSPPGPASKRVRTAYTSAQLVELEKEFHFNRYLCRPRR 224

  Fly   532 IEIANTLQLNETQVKIWFQNRRMKQKKRVK-EGLIPADILTQHSTSVISEKPPQQQQPQ--PPEL 593
            :|:||.|.|.|.|:||||||||||.||..| :|::       ||        |..|.|:  ||
  Rat   225 VEMANLLNLTERQIKIWFQNRRMKYKKDQKAKGIL-------HS--------PAGQSPERSPP-- 272

  Fly   594 QLKSQGSDLGGNE--------------LATGAPSTPTTAMT---------LTAPTS 626
                    |||..              ||..|||.|..|.:         .|||.|
  Rat   273 --------LGGAAGHVAYSGQLPPVPGLAYDAPSPPAFAKSQPNMYGLAAYTAPLS 320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lab	NP_476613.1	Homeobox	505..557	CDD:278475	37/51 (73%)
Hoxd3	NP_001257967.1	Homeobox	198..251	CDD:395001	37/52 (71%)
Hoxd3	NP_001257967.1	DUF4074	369..430	CDD:404218
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X14
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.900