DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment lab and Hoxd1

DIOPT Version :9

Sequence 1:NP_476613.1 Gene:lab / 40817 FlyBaseID:FBgn0002522 Length:629 Species:Drosophila melanogaster
Sequence 2:NP_001099354.1 Gene:Hoxd1 / 288151 RGDID:1309179 Length:328 Species:Rattus norvegicus


Alignment Length:471 Identity:116/471 - (24%)
Similarity:151/471 - (32%) Gaps:223/471 - (47%)


- Green bases have known domain annotations that are detailed below.


  Fly   133 TTGNPGTPLHPSSHSPADSYYESDSVHSYYATAAVATVAPPSNSSPITAANASATSNTQQQQQQA 197
            |...|..|..|....||.|.|...::...|...|    ||.|                       
  Rat    65 TPSPPVAPAQPPGPQPAASRYAPCTLEGAYERGA----APAS----------------------- 102

  Fly   198 AIISSENGMMYTNLDCMYPTAQAQAPVHGYAGQIEEKYAAVLHASYAPGMVLEDQDPMMQQATQS 262
               ::|.|.:            ...|...:.|              |.|...:|..|.:..||.:
  Rat   103 ---AAEYGFL------------GSGPAFDFPG--------------ALGRAADDSGPHVHYATSA 138

  Fly   263 QMWHHQQHLAGSYALDAMDSLGMHAHMHHGLPHGHLGNLANNPHQQQPQVQQQQQQPHQQP---Q 324
            ..     ...||:.|.........|                              :|...|   :
  Rat   139 VF-----SSGGSFLLSGQVDFAAFA------------------------------EPGPFPACLK 168

  Fly   325 HPQNQSPAAHQQHHQNSVSPNGGMNRQQRGGVISPGSSTSSSTSASNGAHPASTQSKSP-NHSSS 388
            .|.:..|...|     :|||             :||:...          |||..|..| .||  
  Rat   169 EPADGHPGPFQ-----TVSP-------------APGACPK----------PASPTSGLPAAHS-- 203

  Fly   389 IPTYKWMQLKRNVPKPQAPKLPASGIASMHDYQMNGQLDMCRGGGGGGSGVGNGPVGVGGNGSPG 453
              |::||::|||.||.          :.:.:|                                 
  Rat   204 --TFEWMKVKRNAPKK----------SKLSEY--------------------------------- 223

  Fly   454 IGGVLSVQNSLIMANSAAAAGSAHPNGMGVGLGSGSGLSSCSLSSNTNNSGRTNFTNKQLTELEK 518
                                |:..|                      :::.||||:.||||||||
  Rat   224 --------------------GATSP----------------------SSAIRTNFSTKQLTELEK 246

  Fly   519 EFHFNRYLTRARRIEIANTLQLNETQVKIWFQNRRMKQKKRVKEGLI--PADI----LTQHSTSV 577
            |||||:|||||||:||||.||||:|||||||||||||||||.:|||:  .|.:    |....||.
  Rat   247 EFHFNKYLTRARRMEIANCLQLNDTQVKIWFQNRRMKQKKREREGLLATAASVASLQLPGSETSP 311

  Fly   578 ISE-----KPPQQQQP 588
            |..     .|.|.|:|
  Rat   312 IKSGRNLGSPSQAQEP 327

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
labNP_476613.1 Homeobox 505..557 CDD:278475 45/51 (88%)
Hoxd1NP_001099354.1 COG5576 <208..325 CDD:227863 68/201 (34%)
Homeobox 233..285 CDD:278475 45/51 (88%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 103 1.000 Domainoid score I6643
eggNOG 1 0.900 - - E2759_KOG0489
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm45556
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45946
Phylome 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X14
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
66.000

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