Protein Alignment lab and VAX2

DIOPT Version :10

• Sequence 1: NP_476613.1
• Gene: lab / 40817
• FlyBaseID: FBgn0002522
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_036608.1
• Gene: VAX2 / 25806
• HGNCID: 12661
• Length: 290
• Species: Homo sapiens
• Alignment Length: 245
• Identity: 64/245 - (26%)
• Similarity: 84/245 - (34%)
• Gaps: 68/245 - (27%)

  Fly   424 GQLDMCRGGGGGG-------------SGVGNGPVGVGG----------------NGSPGIGGVLS 459
            |.......|||||             .|.|:.|..|.|                :|.||.|....
Human    11 GPARRAESGGGGGRCGDRSGAGDLRADGGGHSPTEVAGTSASSPAGSRESGADSDGQPGPGEADH 75

  Fly   460 VQNSLIMANSAAAAGSAHPNGMGVGLGSGSGLSSCSLSSNTNNSGRTNFTNKQLTELEKEFHFNR 524
            .:..|:............|.|               |..:.....||:||.:||..||.||...:
Human    76 CRRILVRDAKGTIREIVLPKG---------------LDLDRPKRTRTSFTAEQLYRLEMEFQRCQ 125

  Fly   525 YLTRARRIEIANTLQLNETQVKIWFQNRRMKQKK------------RVKEGLIPADILTQHSTSV 577
            |:....|.|:|..|.|:|||||:||||||.||||            ...|....::||.......
Human   126 YVVGRERTELARQLNLSETQVKVWFQNRRTKQKKDQSRDLEKRASSSASEAFATSNILRLLEQGR 190

  Fly   578 ISEKPPQQQ----QPQPPELQLKSQGSDLGG--------NELATGAPSTP 615
            :...|....    .|..|.|....:|:.||.        |.|::.:.|.|
Human   191 LLSVPRAPSLLALTPSLPGLPASHRGTSLGDPRNSSPRLNPLSSASASPP 240

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lab	NP_476613.1	Homeodomain	505..558	CDD:459649	29/52 (56%)
VAX2	NP_036608.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..75		15/63 (24%)
		Homeodomain	103..159	CDD:459649	29/55 (53%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	205..240		9/34 (26%)