Protein Alignment lab and Tlx2

DIOPT Version :10

• Sequence 1: NP_476613.1
• Gene: lab / 40817
• FlyBaseID: FBgn0002522
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_033418.1
• Gene: Tlx2 / 21909
• MGIID: 1350935
• Length: 284
• Species: Mus musculus
• Alignment Length: 325
• Identity: 79/325 - (24%)
• Similarity: 116/325 - (35%)
• Gaps: 132/325 - (40%)

  Fly   332 AAHQQHHQNSVSPNGGMNR-----QQRGGVISPGSSTSS---STSASNGAHPASTQSKSPNHSSS 388
            |||...|...:|  .|:::     :..||.:.||.|..|   |.:.|:|.|.||..:
Mouse     7 AAHHLPHHEPIS--FGIDQILSGPEPPGGGLGPGQSGQSHGESAAFSSGFHGASGYA-------- 61

  Fly   389 IPTYKWMQLKRNVPKPQAPKLPASGIASMHDYQMNGQLDMCRGGGGGGSGVGNGPVGVGGNGSPG 453
                                 ||..:||:                ..|||||.
Mouse    62 ---------------------PAGSLASL----------------PRGSGVGP------------ 77

  Fly   454 IGGVLSV---QNSLIMANSAAAAGSAHPNGMGVGLGSGSGLS---------------SCSLS--S 498
             |||:.|   :...:...|.||.....|:|:| |.|..:||:               :.:||  |
Mouse    78 -GGVIRVPAHRPLPVPPPSGAAPAVPGPSGLG-GAGGLAGLTFPWMDSGRRFAKDRLTAALSPFS 140

  Fly   499 NTNNSG--------------RTNFTNKQLTELEKEFHFNRYLTRARRIEIANTLQLNETQVKIWF 549
            .|...|              ||:|:..|:.|||:.|...:||..|.|..:|..|::.:.|||.||
Mouse   141 GTRRIGHPYQNRTPPKRKKPRTSFSRSQVLELERRFLRQKYLASAERAALAKALRMTDAQVKTWF 205

  Fly   550 QNRRMKQKKRVKEGL--------------------------IPADILTQHSTSVISEKPPQQQQP 588
            ||||.|.:::..|..                          :|.|.|..|::|:.:   .|..||
Mouse   206 QNRRTKWRRQTAEEREAERHRAGRLLLHLQQDALPRPLRPPLPPDPLCLHNSSLFA---LQNLQP 267

  Fly   589  588
            Mouse   268  267

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lab	NP_476613.1	Homeodomain	505..558	CDD:459649	24/52 (46%)
Tlx2	NP_033418.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	20..52		8/31 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	78..104		7/25 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	140..166		6/25 (24%)
		Homeodomain	158..214	CDD:459649	24/55 (44%)