DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lab and Hoxd8

DIOPT Version :9

Sequence 1:	NP_476613.1	Gene:	lab / 40817	FlyBaseID:	FBgn0002522	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_032302.2	Gene:	Hoxd8 / 15437	MGIID:	96209	Length:	289	Species:	Mus musculus

Alignment Length:	417	Identity:	102/417 - (24%)
Similarity:	132/417 - (31%)	Gaps:	160/417 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   227 YAGQIEEKY--AAVLHASYAPGMVLEDQDPMMQQATQSQMWHHQQHLAGSYALDAMDSLGMHAHM 289
            :...:..||  ||...|:.|.....|..:|.....      |....::|.:|.    :|.::.:.
Mouse     5 FVNPLYSKYKAAAAAAAAAAAAAAGEAINPTYYDC------HFAPEVSGRHAA----ALQLYGNS 59

  Fly   290 HHGLPHGHLGNLANNPHQQQPQVQQQQQQPHQQPQHPQNQSPAAHQQHHQNSVSPNGGMNRQQRG 354
            ..|.||.|       ||            ||..|..|    |..            ||      |
Mouse    60 AAGFPHAH-------PH------------PHPHPSPP----PGC------------GG------G 83

  Fly   355 GVISPG-----SSTSSSTSASNGAHPASTQSKSPNHSSSIPTYKWMQLKRNVPKPQAPKLPASGI 414
            |...||     :...|.|:|...|.|       |.|                |.|..|..|..||
Mouse    84 GGPGPGQDYFHAGAGSPTAAYQAAPP-------PPH----------------PPPPPPPPPCGGI 125

  Fly   415 ------ASMHDY-----------QMNGQLDM---CRGGGGGGSGVGNGPVGVGGNGSPGIGGVLS 459
                  |..:.|           |...:|..   |:...|   .:|..|..:..:.||
Mouse   126 ACHGEPAKFYGYDNLQRQPIFTTQQEAELVQYPDCKSSSG---NIGEDPDHLNQSSSP------- 180

  Fly   460 VQNSLIMANSAAAAGSAHPNGMGVGLGSGSGLSSCSLSSNTNNSGRTNFTNKQLTELEKEFHFNR 524
             ..........||.|                          ...||..::..|..||||||.||.
Mouse   181 -SQMFPWMRPQAAPG--------------------------RRRGRQTYSRFQTLELEKEFLFNP 218

  Fly   525 YLTRARRIEIANTLQLNETQVKIWFQNRRMKQKKRVKEGLIPADILTQHSTSVISEKPPQQQQPQ 589
            ||||.||||:::||.|.|.||||||||||||.||...:...||             ..|:.:...
Mouse   219 YLTRKRRIEVSHTLALTERQVKIWFQNRRMKWKKENNKDKFPA-------------SRPEAKDGD 270

  Fly   590 PPELQLKSQGSDLGGNELATGAPSTPT 616
            |.:        ::.|.| ..||...||
Mouse   271 PKK--------EVSGLE-EDGAEGCPT 288

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lab	NP_476613.1	Homeobox	505..557	CDD:278475	34/51 (67%)
Hoxd8	NP_032302.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	62..125		28/126 (22%)
		COG5576	139..272	CDD:227863	51/182 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	162..184		5/32 (16%)
		Antp-type hexapeptide	183..188		0/4 (0%)
		Homeobox	199..251	CDD:278475	34/51 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	252..289		11/59 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X14
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.900