DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lab and Hoxd3

DIOPT Version :9

Sequence 1:	NP_476613.1	Gene:	lab / 40817	FlyBaseID:	FBgn0002522	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_034598.2	Gene:	Hoxd3 / 15434	MGIID:	96207	Length:	433	Species:	Mus musculus

Alignment Length:	510	Identity:	121/510 - (23%)
Similarity:	151/510 - (29%)	Gaps:	243/510 - (47%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 SYYESDSVHSYY----ATAAVATVAPPSNSSPITAANASATSNTQQQQQQAAIISSENGMMYTNL 211
            :|||:..:...|    ||.......|.....|..|||                          :|
Mouse    21 AYYENPGLFGGYGYSKATDTYGYSTPHQPYPPPAAAN--------------------------SL 59

  Fly   212 DCMYPTA----QAQAPVHGYAGQIEEKYAAVLHASYAPGMVLEDQDPMMQQATQSQMWHHQQHLA 272
            |..||::    |:.||:.                  ||.                   |....|.
Mouse    60 DSDYPSSACSIQSSAPLR------------------APA-------------------HKGAELN 87

  Fly   273 GSYALDAMDSLGMHAHMHHGLPHGHLGNLANNPHQQQPQVQQQQQQPHQQPQHPQNQSPAAHQQH 337
            ||.             |..|..:...|...|.|    |.:..:||.|...|..|....|:
Mouse    88 GSC-------------MRPGTGNSQGGGGGNQP----PGLNSEQQPPQPPPPPPPTLPPS----- 130

  Fly   338 HQNSVSPNGGMNRQQRGGVISPGSSTSSSTSASNGAHPASTQSKSPNHSSSIPTYKWMQLKRNVP 402
              :..:|..|:          |...|....|||:.   :||.||.        .:.||:..|
Mouse   131 --SPTNPGSGV----------PAKKTKGGLSASSS---SSTISKQ--------IFPWMKESR--- 169

  Fly   403 KPQAPKLPASGIASMHDYQMNGQLDMCRGGGGGGSGVGNGPVGVGGNGSPGIGGVLSVQNSLIMA 467
                                                                      |||. ..
Mouse   170 ----------------------------------------------------------QNSK-QK 175

  Fly   468 NSAAAAGSAHPNGMGVGLGSGSGLSSCSLSSNTNNSGRTNFTNKQLTELEKEFHFNRYLTRARRI 532
            ||.|.              ||......|.....:...||.:|:.||.||||||||||||.|.||:
Mouse   176 NSCAT--------------SGENCEDKSPPGPASKRVRTAYTSAQLVELEKEFHFNRYLCRPRRV 226

  Fly   533 EIANTLQLNETQVKIWFQNRRMKQKKRVK-EGLIPADILTQHSTSVISEKPPQQQQPQ--PPELQ 594
            |:||.|.|.|.|:||||||||||.||..| :|::       ||        |..|.|:  ||
Mouse   227 EMANLLNLTERQIKIWFQNRRMKYKKDQKAKGIL-------HS--------PAGQSPERSPP--- 273

  Fly   595 LKSQGSDLGGNE--------------LATGAPSTPTTAMT---------LTAPTS 626
                   |||..              ||..|||.|..|.:         .|||.|
Mouse   274 -------LGGAAGHVAYSGQLPPVPGLAYDAPSPPAFAKSQPNMYGLAAYTAPLS 321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lab	NP_476613.1	Homeobox	505..557	CDD:278475	37/51 (73%)
Hoxd3	NP_034598.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	44..198		53/337 (16%)
		Antp-type hexapeptide	161..166		1/4 (25%)
		Homeobox	199..251	CDD:278475	37/51 (73%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	258..280		11/46 (24%)
		DUF4074	370..431	CDD:290032
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	401..433
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X14
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.900