DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lab and Hoxd1

DIOPT Version :9

Sequence 1:	NP_476613.1	Gene:	lab / 40817	FlyBaseID:	FBgn0002522	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_034597.2	Gene:	Hoxd1 / 15429	MGIID:	96201	Length:	328	Species:	Mus musculus

Alignment Length:	281	Identity:	93/281 - (33%)
Similarity:	119/281 - (42%)	Gaps:	115/281 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   337 HHQNSVSPNGGMNRQQRGGVI-----SPGSSTSSSTSASNGAHPASTQSKSP---------NHSS 387
            |:..|...:||.:....|.|.     .||...:.....::| ||...|:.||         :.:|
Mouse   133 HYATSAVFSGGGSFLLSGQVDFAAFGEPGPFPACLKEPADG-HPGPFQTVSPAPGACPKPASPTS 196

  Fly   388 SIP----TYKWMQLKRNVPKPQAPKLPASGIASMHDYQMNGQLDMCRGGGGGGSGVGNGPVGVGG 448
            |:|    |::||::|||.||.          :.:.:|                           |
Mouse   197 SLPAAHSTFEWMKVKRNAPKK----------SKLSEY---------------------------G 224

  Fly   449 NGSPGIGGVLSVQNSLIMANSAAAAGSAHPNGMGVGLGSGSGLSSCSLSSNTNNSGRTNFTNKQL 513
            ..||                         |:.:                       ||||:.|||
Mouse   225 ATSP-------------------------PSAI-----------------------RTNFSTKQL 241

  Fly   514 TELEKEFHFNRYLTRARRIEIANTLQLNETQVKIWFQNRRMKQKKRVKEGLIP-----ADI-LTQ 572
            ||||||||||:||||||||||||.||||:|||||||||||||||||.:|||:.     |.| |.:
Mouse   242 TELEKEFHFNKYLTRARRIEIANCLQLNDTQVKIWFQNRRMKQKKREREGLLATAASVASIKLPR 306

  Fly   573 HSTSVISE-----KPPQQQQP 588
            ..||.|..     .|.|.|:|
Mouse   307 SETSPIKSGRNLGSPSQAQEP 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lab	NP_476613.1	Homeobox	505..557	CDD:278475	46/51 (90%)
Hoxd1	NP_034597.2	PRK04233	59..>105	CDD:305134
		Antp-type hexapeptide	204..209		2/4 (50%)
		Homeobox	233..285	CDD:278475	46/51 (90%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	304..328		8/24 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	104	1.000	Domainoid score	I6687
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43494
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45946
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2567
SonicParanoid	1	1.000	-	-		X14
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.030