Protein Alignment lab and Hoxa4

DIOPT Version :10

• Sequence 1: NP_476613.1
• Gene: lab / 40817
• FlyBaseID: FBgn0002522
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_032291.1
• Gene: Hoxa4 / 15401
• MGIID: 96176
• Length: 285
• Species: Mus musculus
• Alignment Length: 310
• Identity: 93/310 - (30%)
• Similarity: 121/310 - (39%)
• Gaps: 77/310 - (24%)

  Fly   291 HGLPHGHLGNLANNPHQQQPQVQQQ--QQQPHQQPQHPQNQSPAAHQQHHQNSVSPNGGMNRQQR 353
            ||.|.|..|.:...|...:||....  ...||...|.|...:|.|.:..:...:.|
Mouse    26 HGGPGGGDGAVGGGPGYPRPQSAPHLPAPNPHAARQPPAYYAPRAREPSYPGGLYP--------- 81

  Fly   354 GGVISPGSSTSSSTSASNGAHPA-STQSKSPN-HSSSIPTYKWMQLKRNVPKPQAPKLPASGIAS 416
                   :..::...|..||.|| ..||.:|. |.|              |.||.|..|..
Mouse    82 -------APAAACPYACRGASPARPEQSPAPGAHPS--------------PAPQPPAPPRH---- 121

  Fly   417 MHDYQMNGQLDMCRGGGGGGSGVGNGPVGVGGNGSPGIGGVLSVQNSLIMANSAAAAGSAHPNGM 481
                        |..|       ...|....|..:|..        .|::|:.    |.|.|.|.
Mouse   122 ------------CAPG-------PTTPAVATGGSAPAC--------PLLLADQ----GPAGPKGK 155

  Fly   482 GVGLGSGSGLSSCSLSSNTNNSG-----RTNFTNKQLTELEKEFHFNRYLTRARRIEIANTLQLN 541
            ...:.........|..:::.|.|     ||.:|.:|:.||||||||||||||.||||||:||.|:
Mouse   156 EPVVYPWMKKIHVSAVNSSYNGGEPKRSRTAYTRQQVLELEKEFHFNRYLTRRRRIEIAHTLCLS 220

  Fly   542 ETQVKIWFQNRRMKQKKRVKEGLIPADILTQHSTSVISEKPPQQQQPQPP 591
            |.||||||||||||.||..|   :|...:...:|:.....||.:.|...|
Mouse   221 ERQVKIWFQNRRMKWKKDHK---LPNTKMRSSNTASAPAGPPGKAQTHSP 267

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lab	NP_476613.1	Homeodomain	505..558	CDD:459649	40/52 (77%)
Hoxa4	NP_032291.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	19..70		13/43 (30%)
		PHA03247	<43..161	CDD:223021	35/182 (19%)
		Antp-type hexapeptide	159..164		0/4 (0%)
		Homeodomain	181..237	CDD:459649	40/55 (73%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	238..285		7/33 (21%)