DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment twr and sec11a

DIOPT Version :9

Sequence 1:	NP_649676.1	Gene:	twr / 40815	FlyBaseID:	FBgn0262801	Length:	185	Species:	Drosophila melanogaster
Sequence 2:	NP_001002521.1	Gene:	sec11a / 436794	ZFINID:	ZDB-GENE-040718-227	Length:	179	Species:	Danio rerio

Alignment Length:	180	Identity:	136/180 - (75%)
Similarity:	158/180 - (87%)	Gaps:	1/180 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 MLQIDEMLGDFNRMNKRQSLYQVLSFAMIVSSALMIWKGLMVVTGSESPIVVVLSGSMEPAFHRG 70
            ||.:| .|.|..||||||..||||:|.||||||||||||||||||||||||||||||||||.|||
Zfish     1 MLSLD-FLDDVRRMNKRQLYYQVLNFGMIVSSALMIWKGLMVVTGSESPIVVVLSGSMEPALHRG 64

  Fly    71 DLLFLTNYKEEPVRVGEIVVFKVEGRDIPIVHRVIKLHEKEDGSVKFLTKGDNNNVDDRGLYAPN 135
            |||||||..|:|:||||||||::|||:|||||||:|:||||:|.:|||||||||:|||||||...
Zfish    65 DLLFLTNRVEDPIRVGEIVVFRIEGREIPIVHRVLKIHEKENGDIKFLTKGDNNSVDDRGLYKQG 129

  Fly   136 QLWLTKKDIVGRARGFLPYVGIITIFMNEYPKVKWAILSILAIFVLLHRE 185
            |.||.|||:|||||||:||:||:||.||:|||.|:|:|.:|.:|||:|||
Zfish   130 QHWLEKKDVVGRARGFVPYIGIVTILMNDYPKFKYAVLCLLGLFVLVHRE 179

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
twr	NP_649676.1	Peptidase_S24_S26	28..181	CDD:415851	118/152 (78%)
sec11a	NP_001002521.1	Peptidase_S24_S26	38..>150	CDD:299172	90/111 (81%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578004
Domainoid	1	1.000	121	1.000	Domainoid score	I5655
eggNOG	1	0.900	-	-		E1_COG0681
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	285	1.000	Inparanoid score	I2836
OMA	1	1.010	-	-		QHG54172
OrthoDB	1	1.010	-	-		D1486616at2759
OrthoFinder	1	1.000	-	-		FOG0001985
OrthoInspector	1	1.000	-	-		oto39651
orthoMCL	1	0.900	-	-		OOG6_100807
Panther	1	1.100	-	-	LDO	PTHR10806
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2283
SonicParanoid	1	1.000	-	-		X1299
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800