DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Taf1 and HAF2

DIOPT Version :9

Sequence 1:	NP_001246952.1	Gene:	Taf1 / 40813	FlyBaseID:	FBgn0010355	Length:	2172	Species:	Drosophila melanogaster
Sequence 2:	NP_001327580.1	Gene:	HAF2 / 821437	AraportID:	AT3G19040	Length:	1792	Species:	Arabidopsis thaliana

Alignment Length:	1911	Identity:	417/1911 - (21%)
Similarity:	708/1911 - (37%)	Gaps:	592/1911 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   230 EEPAKSNDASSPSDDSKSTDSKDADRKLDTPLADILPSKYQNVDVRELFPDFRPQKVLRFSRLFG 294
            |:|.|....:|...:....|:.|...:|...|::....:.:...:..|:.:.....:|:||.:|.
plant    92 EKPVKHEKEASILGNKNQMDTGDVQEELVVGLSEATLDEKRVTPLPTLYLEDDGMVILQFSEIFA 156

  Fly   295 PGKPTSLPQIWRHVRKRRRKRNQSRDQKTTNTGGSDSPSDTEEPRKRGFSLHYAAEPTPAECMSD 359
            ..:|          :|:|:||                     |.|...:...|.:... :|.:.|
plant   157 IQEP----------QKKRQKR---------------------EIRCITYRDKYISMDI-SELIED 189

  Fly   360 DEDKLLGDFNSEDVRPEGPDNGENSDQKPKVADWRFGPAQIWYDM-LEVPDSGEGFNYGFKTKAA 423
            ||:.||......|.      :|:.:|             ||..|: |.:.:..:....|......
plant   190 DEEVLLKSHGRIDT------HGKKTD-------------QIQLDVPLPIRERSQLVKSGIVRDTT 235

  Fly   424 STSSQ-PQLKDERRVKSP--EDDVEDPSIADDAFLMVSQL----------HWEDDVVWD-GNDIK 474
            |.|.: .:|..:..:...  :.|::|    |::.|..|||          .||..::|: .....
plant   236 SESREFTKLGRDSCIMGELLKQDLKD----DNSSLCQSQLTMEVFPLDQQEWEHLILWEISPQFS 296

  Fly   475 AKVLQKLNSKTNAAGWL-----------------PSSGSRTAGAFSQPGKPSM--PVGSGSSK-- 518
            |...:...|...:||.:                 .:||.:|.|..:...:|..  |:.|..|:
plant   297 ANCCEGFKSGLESAGIMVQVRASNSVTEQESLNVMNSGGQTQGDNNNMLEPFFVNPLESFGSRGS 361

  Fly   519 QGSGASSKKAQQNAQAKPAEAP-DDTWY----------------------SLFPVENEELIYYKW 560
            |.:..|:.|::.:.|....|:. |:..|                      |...:::.::....|
plant   362 QSTNESTNKSRHHPQLLRLESQWDEDHYRENGDAGRENLKQLNSDARGRLSGLALQDRDMWDESW 426

  Fly   561 EDEVIWDAQQVSKVPKPKVLTLDPNDENIILGIPDDIDPSKINKSTGPPPKIKIPHPHVKKSKIL 625
            .|.:||::.:.....|   |..|..||.:|..:|::                       |:.|.|
plant   427 LDSIIWESDKDLSRSK---LIFDLQDEQMIFEVPNN-----------------------KERKYL 465

  Fly   626 LGKAGVINVLAEDTPPPPPKSPDRD-----------PFNISNDTYYTPKTEPTLRLKVGGNL--- 676
            ...|| ..:::..:     ||.|..           .||||||.:|.......   |:.||.
plant   466 QLHAG-SRIVSRSS-----KSKDGSFQEGCGSNSGWQFNISNDKFYMNGKSAQ---KLQGNAKKS 521

  Fly   677 ------IQHSTPVVELRAPFVPTHMGPMKLRA-------FHRPPLKKYSHG-----------PMA 717
                  :.||.|.::|:.         ||::.       ||||....|.|.           |..
plant   522 TVHSLRVFHSAPAIKLQT---------MKIKLSNKERANFHRPKALWYPHDNELAIKQQKILPTQ 577

  Fly   718 QSIPHPVFPL-----LKTIAK-------KAKQ------REVERIASGGGDVFFM----------- 753
            .|:...|..|     |.|:.:       |||.      :|.|.:     .:|:|
plant   578 GSMTIVVKSLGGKGSLLTVGREESVSSLKAKASRKLDFKETEAV-----KMFYMGKELEDEKSLA 637

  Fly   754 ---------------------------------------RNPEDLSGRDGDIVLAEFCEEHPPLI 779
                                                   :...|||.:||.:.|.|:|||.|.::
plant   638 EQNVQPNSLVHLLRTKVHLWPWAQKLPGENKSLRPPGAFKKKSDLSNQDGHVFLMEYCEERPLML 702

  Fly   780 NQVGMCSKIKNYYKRKAEKDS------GPQDFVYGEVAFAH--TSPFLGILHPGQCIQAIENNMY 836
            :..||.:.:..||::.:.:|.      ...|.:...:...|  .|||||.:|.|....::|.|||
plant   703 SNAGMGANLCTYYQKSSPEDQHGNLLRNQSDTLGSVIILEHGNKSPFLGEVHGGCSQSSVETNMY 767

  Fly   837 RAPIYPHKMAHNDFLVIRT-RNNYWIRSVNSIYTVGQECPLYEVPGPNSKRANNFTRDFLQVFIY 900
            :||::||::...|:|::|: :....:|.:|.|..|||:.|..|:..|.||..:.:..:.:..::|
plant   768 KAPVFPHRLQSTDYLLVRSAKGKLSLRRINKIVAVGQQEPRMEIMSPASKNLHAYLVNRMMAYVY 832

  Fly   901 RLFWKSRDNPRRIRMDDIKQAFPAHSESSIRKRLKQCADFKRTGMDSNWWVIKPEF-RLPSEEEI 964
            |.| |.||   ||..|::..:|...|::::||.::.|:|.:|.......|..|.:| ::|.  .:
plant   833 REF-KHRD---RIAADELSFSFSNISDATVRKYMQVCSDLERDANGKACWSKKRKFDKIPL--GL 891

  Fly   965 RAMVSPEQCCAYFSMIAAEQRLKDAGYGEKFL-------FAPQEDDDEEAQLKLDDEVKVAPWNT 1022
            ..:|:||..|:|.||:|...|||..|.....|       .|...|:...|...:..|:::.|||.
plant   892 NTLVAPEDVCSYESMLAGLFRLKHLGITRFTLPASISTALAQLPDERIAAASHIARELQITPWNL 956

  Fly  1023 TRAYIQ-AMRGK---CLLQLSGPADPTGCGEGFSYVRVPNKPTQTKEEQESQPKR-----SVTGT 1078
            :.:::. |.:|:   ..|:::|..||:|.|.|||||||..|.:...|.::.:...     :||||
plant   957 SSSFVTCATQGRENIERLEITGVGDPSGRGLGFSYVRVAPKSSAASEHKKKKAAACRGVPTVTGT 1021

  Fly  1079 DADLRRLPLQRAKELLRQFKVPEEEIKKLSRWEVIDVVRTLSTEKA----KAGEEGMDKFSRGNR 1139
            |||.|||.::.|:|:|.:|.||:|.|.|.::.....::|.:|:|:|    |.|...:..|||..|
plant  1022 DADPRRLSMEAAREVLLKFNVPDEIIAKQTQRHRTAMIRKISSEQAASGGKVGPTTVGMFSRSQR 1086

  Fly  1140 FSIAEHQERYKEECQRIFDLQNRVLASSEVLSTDEAESSASEESDLEELGKNLENML-------- 1196
            .|..:.|::.:|.|..|:|.|...|::.:   .|..||.....|||:....:||::|
plant  1087 MSFLQLQQQAREMCHEIWDRQRLSLSACD---DDGNESENEANSDLDSFVGDLEDLLDAEDGGEG 1148

  Fly  1197 --SNKKTSTQLS--------------REREELERQ-----ELLRQLDEEHGGP---------SGS 1231
              |||..:.:|.              .:.||:|.:     ||.|.|.::....         .|.
plant  1149 EESNKSMNEKLDGVKGLKMRRWPSQVEKDEEIEDEAAEYVELCRLLMQDENDKKKKKLKDVGEGI 1213

  Fly  1232 GGAKGAKGKDDP--GQQMLATNNQGRILRITRTFRGNDGKEYTRVETVRRQPVIDAYIKIRTTKD 1294
            |.....:...:|  .::.:||......|.:..:             ||:....:|.... ::.||
plant  1214 GSFPPPRSNFEPFIDKKYIATEPDASFLIVNES-------------TVKHTKNVDKATS-KSPKD 1264

  Fly  1295 EQFIKQFATLDEQQKEEMKREKRRIQEQLRRIKRNQERERLAQLAQNQKLQPGGMPTSLGDPKSS 1359
            :| :|:..|...|.|:.:|                          :|||:..|
plant  1265 KQ-VKEIGTPICQMKKILK--------------------------ENQKVFMG------------ 1290

  Fly  1360 GGHSHKERDSGYKEVSPSRKKFKLKPDLKLKCGACGQVGHMRTNKACPLY--------SGMQSSL 1416
                          ...:|..|        .||||||.|||:|||.||.|        ..|....
plant  1291 --------------KKTARANF--------VCGACGQHGHMKTNKHCPKYRRNTESQPESMDMKK 1333

  Fly  1417 SQSNPSLAD----------DFDEQSEKEMTM-----------------DDDDLVNV----DGTKV 1450
            |...||.:|          |..:.:.|..|.                 ...|:..|    .|||:
plant  1334 STGKPSSSDLSGEVWLTPIDNKKPAPKSATKISVNEATKVGDSTSKTPGSSDVAAVSEIDSGTKL 1398

  Fly  1451 T-----LSSK----------------ILKRHGGDDGKRR------SG-----------SSSGFTL 1477
            |     :|||                ::..:..:.|:..      ||           :||.:|.
plant  1399 TSRKLKISSKAKPKASKVESDSPFHSLMPAYSRERGESELHNPSVSGQLLPSTETDQAASSRYTT 1463

  Fly  1478 KVPRDAMGKKKRRVGGDLHCDYLQRHN---KTANRRRTDPVVVLSSILEIIHNELRSMPDVSPFL 1539
            .||:.::...|.:      .:..:.|.   ....:..:...:|:..:.||..::..|:
plant  1464 SVPQPSLSIDKDQ------AESCRPHRVIWPPTGKEHSQKKLVIKRLKEITDHDSGSL------- 1515

  Fly  1540 FPVSAKKVPDYYRVVTKPMDLQTMREYIRQRRYTSREMFL-----EDLK----QIVDNSLIYNGP 1595
                 ::.|.:....||.|  ..:.::.||:|....|.||     :|.|    |.:...|...|.
plant  1516 -----EETPQFESRKTKRM--AELADFQRQQRLRLSENFLDWGPKDDRKWRKEQDISTELHREGK 1573

  Fly  1596 -QSAY---TLAAQRMFSSCFE-------LLAEREDKLMRLEKA---------------------- 1627
             :.||   |::.:|  |...|       :.:|||::..|..|.
plant  1574 VRRAYDDSTVSEER--SEIAESRRYREVIRSEREEEKRRKAKQKKKLQRGILENYPPRRNDGISS 1636

  Fly  1628 -----INPLLDDD-----------------DQVALSFIFDKLHS--QIKQLPESWPFLKPVNKKQ 1668
                 ||.|...|                 .||.|:.|.:.:..  ::|::..|:.|||||.||:
plant  1637 ESGQNINSLCVSDFERNRTEYAPQPKRRKKGQVGLANILESIVDTLRVKEVNVSYLFLKPVTKKE 1701

  Fly  1669 VKDYYTVIKRPMDLETIGKNIEAHRYHSRAEYLADIELIATNCEQYN-GSDTRYTKFSKKILEYA 1732
            ..:|..::|.||||.||...:....|..|.::..|:..|..|...|| |.:......:.::|...
plant  1702 APNYLEIVKCPMDLSTIRDKVRRMEYRDRQQFRHDVWQIKFNAHLYNDGRNLSIPPLADELLVKC 1766

  Fly  1733 QTQLIEFSEHCGQLENNIAKTQERAR 1758
            ...|.|:.:...:.|..|..:.:..|
plant  1767 DRLLDEYRDELKEAEKGIVDSSDSLR 1792

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Taf1	NP_001246952.1	TBP-binding	15..76	CDD:286347
		DUF3591	652..1114	CDD:288969	158/582 (27%)
		zf-CCHC_6	1388..>1418	CDD:291934	16/37 (43%)
		Bromo_TFIID	1518..1629	CDD:99943	29/157 (18%)
		Bromo_TFIID	1640..1751	CDD:99943	31/113 (27%)
HAF2	NP_001327580.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	205	1.000	Domainoid score	I833
eggNOG	1	0.900	-	-		E1_COG5179
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	388	1.000	Inparanoid score	I508
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D103411at2759
OrthoFinder	1	1.000	-	-		FOG0004441
OrthoInspector	1	1.000	-	-		otm3239
orthoMCL	1	0.900	-	-		OOG6_102499
Panther	1	1.100	-	-	O	PTHR13900
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3145
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.960