DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Taf1 and TAF1

DIOPT Version :9

Sequence 1:	NP_001246952.1	Gene:	Taf1 / 40813	FlyBaseID:	FBgn0010355	Length:	2172	Species:	Drosophila melanogaster
Sequence 2:	XP_005262352.1	Gene:	TAF1 / 6872	HGNCID:	11535	Length:	1927	Species:	Homo sapiens

Alignment Length:	2126	Identity:	975/2126 - (45%)
Similarity:	1293/2126 - (60%)	Gaps:	307/2126 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SDNSDDEGSIGNG-LDLTGILFGNIDSEGRLLQDDDGEGRGGTGFDAELRENIGSLSKLGLDSML 68
            ||...||.|.|.| ..|.|.|||||:..|:|        .|.:..|.|.::::..|..|||.|::
Human    22 SDTDSDEDSAGGGPFSLAGFLFGNINGAGQL--------EGESVLDDECKKHLAGLGALGLGSLI 78

  Fly    69 LEVIDLKEAEPPSDDEEEEDARPSAVSASEGMSAFDALKAGVKREDGAVKAQDDAIDYSDITELS 133
            .|                       ::|:|.::..|   ..:..::|.|::.:||:|||||.|::
Human    79 TE-----------------------LTANEELTGTD---GALVNDEGWVRSTEDAVDYSDINEVA 117

  Fly   134 EDCPRTPPEETSTYDDLEDAIPASKVEAKLREDIAQIFKGLCNSCQSDTITFAPLRLGSDLLLYR 198
            ||       |:..|.                    |....|...|.||               |.
Human   118 ED-------ESRRYQ--------------------QTMGSLQPLCHSD---------------YD 140

  Fly   199 ENNSHFVAAKDDKELM---PPPSAPMR-----------SGSGGGIEEP---AKSNDASSPSDDSK 246
            |::........|.:||   |||..||:           |.:|.||..|   |.|:.||...|.|.
Human   141 EDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDSITGVSENGEGIILPSIIAPSSLASEKVDFSS 205

  Fly   247 STDS------------KDADRKLDTPLADI--------LPSKYQNVDVRELFPDFRPQKVLRFSR 291
            |:||            :..|.||..|||.|        |||      |.||||:|||.|||||.|
Human   206 SSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDATKLLPS------VTELFPEFRPGKVLRFLR 264

  Fly   292 LFGPGKPTSLPQIWRHVRKRRRKRNQSRDQKTTNTGGSDSPSDTEEPRKRGFSLHYAAEPTPAEC 356
            ||||||  ::|.:||..|::|:|:::...|: ......:...::|..:|..::..||..|.|.:|
Human   265 LFGPGK--NVPSVWRSARRKRKKKHRELIQE-EQIQEVECSVESEVSQKSLWNYDYAPPPPPEQC 326

  Fly   357 MSDDEDKLLGDFNSEDVRPEGPDNGENSDQKPKVADWRFGPAQIWYDMLEVPDSGEGFNYGFKTK 421
            :||||..::....|:..:..| |..:.:|.||:||:||:|||::|||||.||:.|.||:||||.:
Human   327 LSDDEITMMAPVESKFSQSTG-DIDKVTDTKPRVAEWRYGPARLWYDMLGVPEDGSGFDYGFKLR 390

  Fly   422 AASTSSQPQLKD---ERRVKSPEDDVEDPSIADDAFLMVSQLHWEDDVVWDGNDIKAKVLQKLNS 483
              .|..:|.:|.   |...|..|::..| .:||:.||||:|||||||::|||.|:|.|..:.  .
Human   391 --KTEHEPVIKSRMIEEFRKLEENNGTD-LLADENFLMVTQLHWEDDIIWDGEDVKHKGTKP--Q 450

  Fly   484 KTNAAGWLPSSGSRTAGAFSQPGKPSMPVGSGSSKQGSGASSKKAQQNAQAKPAEAPDDTWYSLF 548
            :.:.|||||||.:|.|.|:             :.:||..|:..             .|..|||:|
Human   451 RASLAGWLPSSMTRNAMAY-------------NVQQGFAATLD-------------DDKPWYSIF 489

  Fly   549 PVENEELIYYKWEDEVIWDAQQVSKVPKPKVLTLDPNDENIILGIPDDIDPSKINKSTGPPPKIK 613
            |::||:|:|.:|||.:|||||.:.::.:|.||||||||||:||.|||:    |...::..|.|..
Human   490 PIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLTLDPNDENLILEIPDE----KEEATSNSPSKES 550

  Fly   614 IPHPHVKKSKILLGKAGVINVLAEDTPPPPPKSPD-RDPFNISNDTYYTPKTEPTLRLKVGGNLI 677
            .....:|||:|||||.|||    ::.|......|: :||:|:|||.||.|| :..||...|||:|
Human   551 KKESSLKKSRILLGKTGVI----KEEPQQNMSQPEVKDPWNLSNDEYYYPK-QQGLRGTFGGNII 610

  Fly   678 QHSTPVVELRAPFVPTHMGPMKLRAFHRPPLKKYSHGPMAQSIPHPVFPLLKTIAKKAKQREVER 742
            |||.|.||||.||.||||||:|||.||||||||||.|.::|..||.|.||||.|.||||.||.||
Human   611 QHSIPAVELRQPFFPTHMGPIKLRQFHRPPLKKYSFGALSQPGPHSVQPLLKHIKKKAKMREQER 675

  Fly   743 IASGGGDVFFMRNPEDLSGRDGDIVLAEFCEEHPPLINQVGMCSKIKNYYKRKAEKDSGPQDFVY 807
            .|||||::||||.|:||:|:|||::|||:.||:.||:.||||.:|||||||||..||.|..|..|
Human   676 QASGGGEMFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATKIKNYYKRKPGKDPGAPDCKY 740

  Fly   808 GEVAFAHTSPFLGILHPGQCIQAIENNMYRAPIYPHKMAHNDFLVIRTRNNYWIRSVNSIYTVGQ 872
            ||..:.|||||||.|||||.:||.|||::|||||.|||...|||:||||..|:||.:..|:.|||
Human   741 GETVYCHTSPFLGSLHPGQLLQAFENNLFRAPIYLHKMPETDFLIIRTRQGYYIRELVDIFVVGQ 805

  Fly   873 ECPLYEVPGPNSKRANNFTRDFLQVFIYRLFWKSRDNPRRIRMDDIKQAFPAHSESSIRKRLKQC 937
            :|||:|||||||||||...|||||||||||||||:|.||||||:|||:|||:|||||||||||.|
Human   806 QCPLFEVPGPNSKRANTHIRDFLQVFIYRLFWKSKDRPRRIRMEDIKKAFPSHSESSIRKRLKLC 870

  Fly   938 ADFKRTGMDSNWWVIKPEFRLPSEEEIRAMVSPEQCCAYFSMIAAEQRLKDAGYGEKFLFAPQED 1002
            ||||||||||||||:|.:||||:||||||||||||||||:|||||||||||||||||..|||:|:
Human   871 ADFKRTGMDSNWWVLKSDFRLPTEEEIRAMVSPEQCCAYYSMIAAEQRLKDAGYGEKSFFAPEEE 935

  Fly  1003 DDEEAQLKLDDEVKVAPWNTTRAYIQAMRGKCLLQLSGPADPTGCGEGFSYVRVPNKPTQTKEEQ 1067
            ::|:.|:|:||||:.||||||||:|.||:|||||:::|.|||||||||||||::||||||.|:::
Human   936 NEEDFQMKIDDEVRTAPWNTTRAFIAAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDK 1000

  Fly  1068 ESQP-KRSVTGTDADLRRLPLQRAKELLRQFKVPEEEIKKLSRWEVIDVVRTLSTEKAKAGEEGM 1131
            |.|| |::|||||||||||.|:.||:|||:|.||||||||||||||||||||:|||:|::||..|
Human  1001 EPQPVKKTVTGTDADLRRLSLKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQARSGEGPM 1065

  Fly  1132 DKFSRGNRFSIAEHQERYKEECQRIFDLQNRVLASSEVLSTDEAESSASEESDLEELGKNLENML 1196
            .||:||:|||:|||||||||||||||||||:||:|:|||||| .:||::|:||.||:|||:||||
Human  1066 SKFARGSRFSVAEHQERYKEECQRIFDLQNKVLSSTEVLSTD-TDSSSAEDSDFEEMGKNIENML 1129

  Fly  1197 SNKKTSTQLSREREELERQELLRQLDEEHGGPSGSGGAKGAKGKDDPGQQMLATNNQ--GRILRI 1259
            .|||||:||||||||.||:||.|.|      .:....|.|...:||....:.:.|:.  ||.|:|
Human  1130 QNKKTSSQLSREREEQERKELQRML------LAAGSAASGNNHRDDDTASVTSLNSSATGRCLKI 1188

  Fly  1260 TRTFRGNDGKEYTRVETVRRQPVIDAYIKIRTTKDEQFIKQFATLDEQQKEEMKREKRRIQEQLR 1324
            .||||..:||||.|.||||:..|||||::|||||||:||::||..|||.:|||::|:||||||||
Human  1189 YRTFRDEEGKEYVRCETVRKPAVIDAYVRIRTTKDEEFIRKFALFDEQHREEMRKERRRIQEQLR 1253

  Fly  1325 RIKRNQERERLAQLAQNQKLQPGGMPTSLGDPKSSGGHSHKERDSGYKEVSPSRKKFKLKPDLKL 1389
            |:|||||:|:|                                 .|..|..|  ||.|.:|||||
Human  1254 RLKRNQEKEKL---------------------------------KGPPEKKP--KKMKERPDLKL 1283

  Fly  1390 KCGACGQVGHMRTNKACPLYSGMQSSLSQSNP-SLADDFDEQSEKEMT-MDDDDLVNVDGTKVTL 1452
            ||||||.:|||||||.||||  .|::...||| ::.::.:|:.||.:. .|:::|:.|:|||:.|
Human  1284 KCGACGAIGHMRTNKFCPLY--YQTNAPPSNPVAMTEEQEEELEKTVIHNDNEELIKVEGTKIVL 1346

  Fly  1453 SSKILKRHGGDDGKRRSGSSSGFTLKVPRDAM-GKKKRRVGGDLHCDYLQRHNKTANRRRTDPVV 1516
            ..::::  ..|:.:|:|     ..||.|:..: .|||||||..:|||||.|.:|:.:||||||:|
Human  1347 GKQLIE--SADEVRRKS-----LVLKFPKQQLPPKKKRRVGTTVHCDYLNRPHKSIHRRRTDPMV 1404

  Fly  1517 VLSSILEIIHNELRSMPDVSPFLFPVSAKKVPDYYRVVTKPMDLQTMREYIRQRRYTSREMFLED 1581
            .||||||.|.|::|.:|:..||..||:||.|.|||:::|:||||||:||.:|:|.|.|||.|.|.
Human  1405 TLSSILESIINDMRDLPNTYPFHTPVNAKVVKDYYKIITRPMDLQTLRENVRKRLYPSREEFREH 1469

  Fly  1582 LKQIVDNSLIYNGPQSAYTLAAQRMFSSCFELLAEREDKLMRLEKAINPLLDDDDQVALSFIFDK 1646
            |:.||.||..||||:.:.|..:|.|...|.|.|.|:||||.|||||||||||||||||.|||.|.
Human  1470 LELIVKNSATYNGPKHSLTQISQSMLDLCDEKLKEKEDKLARLEKAINPLLDDDDQVAFSFILDN 1534

  Fly  1647 LHSQ-IKQLPESWPFLKPVNKKQVKDYYTVIKRPMDLETIGKNIEAHRYHSRAEYLADIELIATN 1710
            :.:| :..:|:||||..|||||.|.|||.||..|||||||.|||..|:|.||..:|.|:.||..|
Human  1535 IVTQKMMAVPDSWPFHHPVNKKFVPDYYKVIVNPMDLETIRKNISKHKYQSRESFLDDVNLILAN 1599

  Fly  1711 CEQYNGSDTRYTKFSKKILEYAQTQLIEFSEHCGQLENNIAKTQERARENAPEFDEAWGNDDYNF 1775
            ..:|||.:::|||.:::|:......|.|:.||..|||.:|...:|.|.|.|    |....|.  .
Human  1600 SVKYNGPESQYTKTAQEIVNVCYQTLTEYDEHLTQLEKDICTAKEAALEEA----ELESLDP--M 1658

  Fly  1776 DRGSRASSPGDDYIDVEGHGGHASSSNSIHRSMGAEAGSSHTAPAVRKPAPPGP--GEVKRGRGR 1838
            ..|.....|.|.|        ..::|.|:.|........|:.:......|.|..  .::::||||
Human  1659 TPGPYTPQPPDLY--------DTNTSLSMSRDASVFQDESNMSVLDIPSATPEKQVTQMRQGRGR 1715

  Fly  1839 PRKQ---------RDPVEEVKSQNPVKRGR--GRPRKDSLASNMSHTQAYFLDEDLQCSTDDEDD 1892
            ..::         .|..|:.|.:.|...|.  .....|.....:...||..|.|||..| :.|||
Human  1716 LGEEDSDVDIEGYDDEEEDGKPKTPAPEGEDGDGDLADEEEGTVQQPQASVLYEDLLMS-EGEDD 1779

  Fly  1893 DEEEDFQEVSEDENNAASILDQGERINAPADAMDGMFDPK-------NIKTEIDLEAHQMAEEPI 1950
            :|:....|..::..:|..:.:.|    :.:|...|...||       |.:.:::.|...|:.|..
Human  1780 EEDAGSDEEGDNPFSAIQLSESG----SDSDVGSGGIRPKQPRMLQENTRMDMENEESMMSYEGD 1840

  Fly  1951 GEDDSQQVAEAMV-----------------QLSGVGGYYAQQQQDESMDVDPNYDPSDFLAMHKQ 1998
            |.:.|..:.::.:                 ..|.:|||...:::::..:.:....||....:|
Human  1841 GGEASHGLEDSNISYGSYEEPDPKSNTQDTSFSSIGGYEVSEEEEDEEEEEQRSGPSVLSQVH-- 1903

  Fly  1999 RQSLGEPSSLQGAFTNFLSHEQDDNGPYNPAEASTSAASGADLGMD 2044
                             ||.:::|:..::      |.|..:||..|
Human  1904 -----------------LSEDEEDSEDFH------SIAGDSDLDSD 1926

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Taf1	NP_001246952.1	TBP-binding	15..76	CDD:286347	20/61 (33%)
		DUF3591	652..1114	CDD:288969	333/462 (72%)
		zf-CCHC_6	1388..>1418	CDD:291934	20/29 (69%)
		Bromo_TFIID	1518..1629	CDD:99943	62/110 (56%)
		Bromo_TFIID	1640..1751	CDD:99943	54/111 (49%)
TAF1	XP_005262352.1	TBP-binding	33..86	CDD:286347	20/83 (24%)
		DUF3591	586..1048	CDD:288969	333/462 (72%)
		zf-CCHC_6	1282..1317	CDD:291934	23/36 (64%)
		Bromo_TFIID	1406..1517	CDD:99943	62/110 (56%)
		Bromo_TFIID	1528..1640	CDD:99943	54/111 (49%)
		SEEEED	<1774..1865	CDD:291463	18/95 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156496
Domainoid	1	1.000	706	1.000	Domainoid score	I123
eggNOG	1	0.900	-	-		E1_COG5179
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37942
Inparanoid	1	1.050	1656	1.000	Inparanoid score	I79
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46172
OrthoDB	1	1.010	-	-		D103411at2759
OrthoFinder	1	1.000	-	-		FOG0004441
OrthoInspector	1	1.000	-	-		otm40291
orthoMCL	1	0.900	-	-		OOG6_102499
Panther	1	1.100	-	-	LDO	PTHR13900
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2307
SonicParanoid	1	1.000	-	-		X3145
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800