DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Taf1 and taf1

DIOPT Version :9

Sequence 1:	NP_001246952.1	Gene:	Taf1 / 40813	FlyBaseID:	FBgn0010355	Length:	2172	Species:	Drosophila melanogaster
Sequence 2:	XP_021331844.1	Gene:	taf1 / 555452	ZFINID:	ZDB-GENE-030131-5576	Length:	1984	Species:	Danio rerio

Alignment Length:	2220	Identity:	995/2220 - (44%)
Similarity:	1320/2220 - (59%)	Gaps:	342/2220 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ESDNSDDEGSIGNGLDLTGILFGNIDSEGRLLQDDDGEGRGGTGFDAELRENIGSLSKLGLDSML 68
            :||:.:|:   .....|||.|||||:..|:|  :||      :..|.|.::::..|..|||.|::
Zfish     3 DSDSDEDQ---DRPFHLTGFLFGNINENGQL--EDD------SVLDTESKKHLAGLGTLGLGSLI 56

  Fly    69 LEVIDLKEAEPPSDDEEEEDARPSAVSASEGMSAFDALKAGVKREDGAVKAQDDAIDYSDITELS 133
            .|:    .|......|:|:|           .|:.||        :|.|::.:||:|||||:|::
Zfish    57 TEI----TASEEETAEQEQD-----------QSSTDA--------EGWVRSTEDAVDYSDISEVA 98

  Fly   134 EDCPRTPPEETSTYDDLEDAIPASKVEAKLREDIAQIFKGLCNSCQSDTITFAPLRLGSDLLLYR 198
            ||       ||..|......:..|:     |.|....:...|...
Zfish    99 ED-------ETRKYRQAMGNLQPSR-----RTDDEDDYDADCEDV-------------------- 131

  Fly   199 ENNSHFVAAKDDKELMPPPSAPMR----------------SGSGGGIEEPA--KSNDASSPSDDS 245
                       |.:|||||..|.:                :..|.||..|:  ..:......|.|
Zfish   132 -----------DSKLMPPPPPPTQPITAKKDDTPTQNSSVTDEGDGIILPSIIAPSSVGDKVDFS 185

  Fly   246 KSTDSK-DADRK------------LDTPLADILPSKYQNV--DVRELFPDFRPQKVLRFSRLFGP 295
            .|:||: ::||.            |..|||.|:.......  .|.||||:|||.|||||.|||||
Zfish   186 SSSDSESESDRPSQGSGTGKKAGCLTLPLAGIMQKDAAKALPGVTELFPEFRPGKVLRFLRLFGP 250

  Fly   296 GKPTSLPQIWRHVRKRRRKRNQSRDQKTTNTGG--SDSPSDTEEPRKRGFSLHYAAEPTPAECMS 358
            ||  ::|.:||..| |:|||.|...|......|  ...||:....:|.|:...||..|.|.:|:|
Zfish   251 GK--NMPSVWRSAR-RKRKRKQKEPQSDMAAAGDIESLPSEPGAKKKSGWDYEYAPPPPPEQCLS 312

  Fly   359 DDEDKLLGDFNSEDVRPEGPDNGENSDQKPKVADWRFGPAQIWYDMLEVPDSGEGFNYGFKTK-- 421
            |||..::....|:.::..| :..:.|:.:||||:||:||||:|||||.||:.|.||:||||.|
Zfish   313 DDEITMMAPVESKFMQVSG-EGDKVSEMRPKVAEWRYGPAQLWYDMLGVPEDGSGFHYGFKLKDD 376

  Fly   422 ------------AASTSSQPQLKDERRVKSPEDDVEDPSIADDAFLMVSQLHWEDDVVWDGNDIK 474
                        |...:|:|..:.|...:|.:...||..:.|:.||||:||.||:|::|:|.|:|
Zfish   377 KQEDNTDAVTKMATPPASEPVPEQEPPQESQDKADEDAPMQDELFLMVTQLQWEEDIIWNGEDVK 441

  Fly   475 AKVLQKLNSKTNAAGWLPSSGSRTAGAF----------SQPGKPSMPVGSGSSKQGSGASSKKAQ 529
            .|..:  ..:.:.|||||:|.:|.|.|:          ||...|:.|   ..:|..|...||:.:
Zfish   442 HKGTK--TQRASLAGWLPTSMTRNANAYNAQQGLSRSNSQLVPPTPP---PLTKTPSITGSKRDK 501

  Fly   530 QNAQAKPAEAPDDTWYSLFPVENEELIYYKWEDEVIWDAQQVSKVPKPKVLTLDPNDENIILGIP 594
            .|...:.:...|..|:|:||::||||:|.:|||.:|||.|.:..:|.|.||||:||||||||.||
Zfish   502 HNHDHQVSHEDDTPWFSIFPIDNEELVYGRWEDNIIWDDQNMDCIPSPPVLTLNPNDENIILEIP 566

  Fly   595 DDID------PSKINKSTGPPPKIKIPHPHVKKSKILLGKAGVINVLAEDTPPPPPKSPD-RDPF 652
            |:.:      |||.||.          ...:|||:|||||.|||    :|.|......|: :||:
Zfish   567 DEKEERTSHSPSKENKK----------ETALKKSRILLGKTGVI----KDEPQQNMSQPEIKDPW 617

  Fly   653 NISNDTYYTPKTEPTLRLKVGGNLIQHSTPVVELRAPFVPTHMGPMKLRAFHRPPLKKYSHGPMA 717
            |:|||.:|.|| :..||...|||:||||.|.||||.||.||||||||||.||||.|||||.|.::
Zfish   618 NLSNDEFYYPK-QQGLRGSFGGNIIQHSIPTVELRQPFFPTHMGPMKLRQFHRPSLKKYSFGALS 681

  Fly   718 QSIPHPVFPLLKTIAKKAKQREVERIASGGGDVFFMRNPEDLSGRDGDIVLAEFCEEHPPLINQV 782
            |..||.|.||||.|.||||.||.||.||||||:||||..:||:|:|||:||||:.||:|||..||
Zfish   682 QPGPHAVQPLLKHIKKKAKMREQERQASGGGDMFFMRTAQDLTGKDGDLVLAEYSEEYPPLHMQV 746

  Fly   783 GMCSKIKNYYKRKAEKDSGPQDFVYGEVAFAHTSPFLGILHPGQCIQAIENNMYRAPIYPHKMAH 847
            ||.||||||||||..||.|..|..|||..:.|||||||.|||||.:||.|||::|||||.|||..
Zfish   747 GMASKIKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQAFENNLFRAPIYLHKMPE 811

  Fly   848 NDFLVIRTRNNYWIRSVNSIYTVGQECPLYEVPGPNSKRANNFTRDFLQVFIYRLFWKSRDNPRR 912
            .|||:||||..|:||.:..|:.|||||||||||||||||||...|||||||||||||||:|.|||
Zfish   812 TDFLIIRTRQGYFIRELVDIFVVGQECPLYEVPGPNSKRANTHIRDFLQVFIYRLFWKSKDRPRR 876

  Fly   913 IRMDDIKQAFPAHSESSIRKRLKQCADFKRTGMDSNWWVIKPEFRLPSEEEIRAMVSPEQCCAYF 977
            |||:|||:|||:|||||||||||.|||||||||||||||:||:||||:||||||||||||||||:
Zfish   877 IRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKPDFRLPTEEEIRAMVSPEQCCAYY 941

  Fly   978 SMIAAEQRLKDAGYGEKFLFAPQEDDDEEAQLKLDDEVKVAPWNTTRAYIQAMRGKCLLQLSGPA 1042
            ||:.|||||||||||||..|||:|:::||.|:|:||||:.||||||||:|.||:|||||:::|.|
Zfish   942 SMLVAEQRLKDAGYGEKSFFAPEEENEEEFQMKIDDEVRTAPWNTTRAFIAAMKGKCLLEVTGVA 1006

  Fly  1043 DPTGCGEGFSYVRVPNKPTQTKEEQESQP-KRSVTGTDADLRRLPLQRAKELLRQFKVPEEEIKK 1106
            ||||||||||||:|||||||.|:::|.|| |::|||||||||||.|:.||:|||:|.||||||||
Zfish  1007 DPTGCGEGFSYVKVPNKPTQQKDDREPQPVKKTVTGTDADLRRLSLKNAKQLLRKFGVPEEEIKK 1071

  Fly  1107 LSRWEVIDVVRTLSTEKAKAGEEGMDKFSRGNRFSIAEHQERYKEECQRIFDLQNRVLASSEVLS 1171
            ||||||||||||:|||:|::||..|.||:||:|||:|||||||||||||||||||:||.|:||||
Zfish  1072 LSRWEVIDVVRTMSTEQARSGEGPMSKFARGSRFSVAEHQERYKEECQRIFDLQNKVLESTEVLS 1136

  Fly  1172 TDEAESSASEESDLEELGKNLENMLSNKKTSTQLSREREELERQELLRQL-----DEEHGGP--- 1228
            || .:||::|:||.||:|||:||||.|||||:||||||||.||:||.|.|     :.|.|..
Zfish  1137 TD-TDSSSAEDSDFEEMGKNIENMLQNKKTSSQLSREREEQERKELQRMLMGEDNERERGRKERR 1200

  Fly  1229 SGSGGAKGAKGKDDPGQQMLATNNQ--GRILRITRTFRGNDGKEYTRVETVRRQPVIDAYIKIRT 1291
            .||.....:..|||....:.:.|:.  ||.|:|.|||...|||||.|.||||:..|||||::|||
Zfish  1201 KGSSALSTSSHKDDDASSVTSLNSSATGRRLKIYRTFCDEDGKEYVRCETVRKPAVIDAYLRIRT 1265

  Fly  1292 TKDEQFIKQFATLDEQQKEEMKREKRRIQEQLRRIKRNQERERLAQLAQNQKLQPGGMPTSLGDP 1356
            |||::||::||..|||.:|||::|:|||||||||:|||||::|..                 |.|
Zfish  1266 TKDDEFIRKFALFDEQHREEMRKERRRIQEQLRRLKRNQEKDRFK-----------------GPP 1313

  Fly  1357 KSSGGHSHKERDSGYKEVSPSRKKFKLKPDLKLKCGACGQVGHMRTNKACPLYSGMQSSLSQSNP 1421
            :.                  ..||.|.:|||||||||||.:|||||||.||||  .|::...|||
Zfish  1314 EK------------------KTKKAKERPDLKLKCGACGAIGHMRTNKFCPLY--YQTNAPPSNP 1358

  Fly  1422 -SLADDFDEQSEKEMT-MDDDDLVNVDGTKVTLSSKILKRHGGDDGKRRSGSSSGFTLKVPRDAM 1484
             ::.::.:|:.||.:. .|:::|:.|:|||:.|..::::  ..|:.:|:|     ..||.|:..:
Zfish  1359 VAMTEEQEEELEKTVIHNDNEELIKVEGTKIVLGKQLIE--SADEVRRKS-----LVLKFPKQQL 1416

  Fly  1485 -GKKKRRVGGDLHCDYL--QRHNKTANRRRTDPVVVLSSILEIIHNELRSMPDVSPFLFPVSAKK 1546
             .|||||||..:|||||  :|.:|:.:||||||:|.|||:||.|.|::|.:|:..||..||:.|.
Zfish  1417 PPKKKRRVGTTVHCDYLNVRRPHKSIHRRRTDPMVTLSSVLESIINDMRDLPNTYPFHTPVNGKV 1481

  Fly  1547 VPDYYRVVTKPMDLQTMREYIRQRRYTSREMFLEDLKQIVDNSLIYNGPQSAYTLAAQRMFSSCF 1611
            |.|||:::|:||||||:||.:|:|.|.|||.|.|.::.|..||..|||.:...|:.||.|.|.|.
Zfish  1482 VKDYYKIITRPMDLQTLRENVRKRMYPSREEFRESVELIFKNSATYNGAKHPLTVVAQAMLSLCV 1546

  Fly  1612 ELLAEREDKLMRLEKAINPLLDDDDQVALSFIFDKLHSQ-IKQLPESWPFLKPVNKKQVKDYYTV 1675
            |.:.|:|::|:|||||||||||||||||.|||.|.:.:| :..:|:||||..|||||.|.|||.|
Zfish  1547 EKIKEKEERLVRLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPDYYKV 1611

  Fly  1676 IKRPMDLETIGKNIEAHRYHSRAEYLADIELIATNCEQYNGSDTRYTKFSKKILEYAQTQLIEFS 1740
            |..||||:|:.|||..|:|.:|..:|:|:.||.||..:|||.|:.|||.:.:|:...:..|.|:.
Zfish  1612 IINPMDLDTLRKNISKHKYQNREVFLSDVGLIHTNSVKYNGPDSPYTKTALEIVNVCKQTLAEYD 1676

  Fly  1741 EHCGQLENNIAKTQERARENAPEFDEAWGNDDYNFD---RGSRASSPGDDYIDVEGHGGHASSSN 1802
            ||..|||.:|...:|.|.:.|         |..:.|   .|.....|     ||        ..|
Zfish  1677 EHLTQLEKDILTAKEAALDAA---------DLESLDPLTPGPYTPQP-----DV--------CEN 1719

  Fly  1803 SIHRSMGAEAGSSHTAPAVRKPAPPGPGEVKRGRGRPRKQRDPVE-EVKSQNPVKRGRGRPRKDS 1866
            |:  |:..:..||..|.|...|..|   |.:.|:||.|.:....| :|..:...:...|:|:..:
Zfish  1720 SV--SVSLQGDSSLLAEATLIPPTP---EKRGGQGRHRGRLGEEESDVDIEGFEEDDDGKPKTPA 1779

  Fly  1867 LASNMSHTQAYFLDEDLQCSTDDEDDDEEED--------FQEVSEDENNAASILDQGERINAPAD 1923
                 .|.|..  |.||    ||||||:|:|        ...:.||::      |..|..:.||.
Zfish  1780 -----PHFQVE--DGDL----DDEDDDDEDDELLMRPPRRMHIDEDDD------DDDEGSSRPAQ 1827

  Fly  1924 A----MDGMFDPKNIKTEIDLEAHQMAEEPIGEDDSQQVAEAMVQLSGVGGYYAQQQQDESMDVD 1984
            |    .|.:..          :|...|.|..|::..     :.:|||..|         ...|.|
Zfish  1828 ASVLYQDLLMS----------DAEDDASEEEGDNPF-----SSIQLSESG---------SDSDAD 1868

  Fly  1985 PNYDPSDFLAMHKQRQSLGEPSSLQGAFTNFLSHEQDDN---GPYNPAEASTSAASGADLGMDAS 2046
            ..:..|..:.:.::...:    |.:|...:.|:|.:|.|   |.|:..              |:.
Zfish  1869 LGHQESTRIGLEQEESMM----SYEGEGPDGLTHMEDSNVSFGSYDDG--------------DSQ 1915

  Fly  2047 MAMQM-APEMPVNTMNNGMGI-DDDLDISESDEEDDGSRVRIKKEVFDDGDYALQHQQMGQAASQ 2109
            |..|: :|......::...|| :::.|..|.||...|..|..:.::.||.:.:.:.:.:|..:.
Zfish  1916 MQRQVSSPRTGERDVDEVYGISEEEEDEEEEDERRRGPSVLTQVQLSDDEEDSEEFRSVGGDSD- 1979

  Fly  2110 SQIYMVDSSN 2119
                 :||.|
Zfish  1980 -----MDSDN 1984

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Taf1	NP_001246952.1	TBP-binding	15..76	CDD:286347	20/60 (33%)
		DUF3591	652..1114	CDD:288969	338/462 (73%)
		zf-CCHC_6	1388..>1418	CDD:291934	20/29 (69%)
		Bromo_TFIID	1518..1629	CDD:99943	56/110 (51%)
		Bromo_TFIID	1640..1751	CDD:99943	53/111 (48%)
taf1	XP_021331844.1	TBP-binding	13..64	CDD:312672	21/62 (34%)
		DUF3591	617..1080	CDD:314945	339/463 (73%)
		zf-CCHC_6	1327..1362	CDD:317662	23/36 (64%)
		Bromo_TFIID	1453..1564	CDD:99943	56/110 (51%)
		Bromo_TFIID	1575..1686	CDD:99943	53/110 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592127
Domainoid	1	1.000	708	1.000	Domainoid score	I118
eggNOG	1	0.900	-	-		E1_COG5179
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37942
Inparanoid	1	1.050	1661	1.000	Inparanoid score	I73
OMA	1	1.010	-	-		QHG46172
OrthoDB	1	1.010	-	-		D103411at2759
OrthoFinder	1	1.000	-	-		FOG0004441
OrthoInspector	1	1.000	-	-		oto40029
orthoMCL	1	0.900	-	-		OOG6_102499
Panther	1	1.100	-	-	LDO	PTHR13900
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2307
SonicParanoid	1	1.000	-	-		X3145
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800