DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Taf1 and CECR2

DIOPT Version :9

Sequence 1:	NP_001246952.1	Gene:	Taf1 / 40813	FlyBaseID:	FBgn0010355	Length:	2172	Species:	Drosophila melanogaster
Sequence 2:	NP_001276976.1	Gene:	CECR2 / 27443	HGNCID:	1840	Length:	1464	Species:	Homo sapiens

Alignment Length:	1423	Identity:	271/1423 - (19%)
Similarity:	420/1423 - (29%)	Gaps:	649/1423 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly   948 NWWVIKPEFRLPSEEEIRAMVSPEQCCAYF-SMIAAEQRLKDAGYGEKFLFAPQEDDDEEAQLKL 1011
            :||            |:.|:       |:| |:.....||.|.           |.::.||.|..
Human    16 SWW------------EVPAI-------AHFCSLFRTAFRLPDF-----------EIEELEAALHR 50

  Fly  1012 DDEVKVAPWNTTRAYIQAMRGKCLLQLSGPADPTGCGEGFSYVRVPNKPTQT------------- 1063
            ||.          .:|..:.. ||||        ||     |.|....| ||
Human    51 DDV----------EFISDLIA-CLLQ--------GC-----YQRRDITP-QTFHSYLEDIINYRW 90

  Fly  1064 -KEEQESQPKRSVTGTDADLRRLPLQRAKELLRQ---FKVPEEEIKKLSRWEVIDVVRTLSTEKA 1124
             .||.:..|.|     :|..:.|||:...|:|.:   :::..:        :|.|:::.|..:..
Human    91 ELEEGKPNPLR-----EASFQDLPLRTRVEILHRLCDYRLDAD--------DVFDLLKGLDADSL 142

  Fly  1125 KAGEEGMDK------FSRGNRFSIAEHQERYKEECQRIFDLQNRVLASSEVLSTDEAESSASEES 1183
            :....|.|.      :..|.|.        |||:               .|......|.|.|.||
Human   143 RVEPLGEDNSGALYWYFYGTRM--------YKED---------------PVQGKSNGELSLSRES 184

  Fly  1184 DLEELGKNLENMLSNKKTSTQLSR--EREELERQELLRQLDEEHGGPSGSGGAKGAKGKDDPGQ- 1245
            :.:   ||:.::..  ||..:..|  :|::|:.:.||.:..||:...|......|::|   |||
Human   185 EGQ---KNVSSIPG--KTGKRRGRPPKRKKLQEEILLSEKQEENSLASEPQTRHGSQG---PGQG 241

  Fly  1246 ---QMLATNNQGRILRITRTFRGNDGKEYTRVETVRRQPVIDAYIKIRTTKDEQFIKQFATLDEQ 1307
               .:..|..:.|  ::|.:||       .|.....||        :.....|.|:.:...:..|
Human   242 TWWLLCQTEEEWR--QVTESFR-------ERTSLRERQ--------LYKLLSEDFLPEICNMIAQ 289

  Fly  1308 QKEEMKREKRRI---------------QEQ---LRRI---KRNQERERLAQLAQNQKLQPGGMPT 1351
            :.:..:|.|..:               ||:   |.||   ||.:|.|....|...||
Human   290 KGKRPQRTKAELHPRWMSDHLSIKPVKQEETPVLTRIEKQKRKEEEEERQILLAVQK-------- 346

  Fly  1352 SLGDPKSSGGHSHKERDSGYKEVSPSRKKFKLKPDLKLKCGACGQVGHMRTNKACPLYSGMQSSL 1416
                         ||::...||   .||:
Human   347 -------------KEQEQMLKE---ERKR------------------------------------ 359

  Fly  1417 SQSNPSLADDFDEQSEKEMTMDDDDLVNVDGTKVTLSSKILKRHGGDDGKRRSGSSSGFTLKVPR 1481
                        |..||...::                        |..|||.       |:..|
Human   360 ------------ELEEKVKAVE------------------------DRAKRRK-------LREER 381

  Fly  1482 D---AMGKKKRRVGGDLHCDYLQRHNKTANRRRTDPVVVLSSILEIIHNELRSMPDVSPFLFPVS 1543
            .   |.||:                                     :..||..:...||
Human   382 AWLLAQGKE-------------------------------------LPPELSHLDPNSP------ 403

  Fly  1544 AKKVPDYYRVVTKPMDLQTMREYIRQRRYTSREMFLEDLKQIVDNSLIYNGPQSAYTLAAQRMFS 1608
                               |||          |...:||
Human   404 -------------------MRE----------EKKTKDL-------------------------- 413

  Fly  1609 SCFELLAEREDKLMRLEKAINPLLDDDDQVALSFIFDKLHSQIKQLPESWPFLKPVNKKQVKDYY 1673
              |||                    |||..|:..:.|    .:|...:|||||:||::....:||
Human   414 --FEL--------------------DDDFTAMYKVLD----VVKAHKDSWPFLEPVDESYAPNYY 452

  Fly  1674 TVIKRPMDLETIGKNIEAHRYHSRAEYLADIELIATNCEQYNGSDTRYTKFSKKILEYAQTQLIE 1738
            .:||.|||:.::.|.:....|.::.|::.|::.:..||.:|||..:.|||.|
Human   453 QIIKAPMDISSMEKKLNGGLYCTKEEFVNDMKTMFRNCRKYNGESSEYTKMS------------- 504

  Fly  1739 FSEHCGQLENNIAKTQERAR------ENAPEFDEAWGNDDYNFD-RGSRASSPGDDYI-----DV 1791
                     :|:.:...||.      |:....:|.|..:|...: |.|||...|..::     |.
Human   505 ---------DNLERCFHRAMMKHFPGEDGDTDEEFWIREDEKREKRRSRAGRSGGSHVWTRSRDP 560

  Fly  1792 EG---------HGG---------------HASSSNSIHRSMGAE--AGSSH---------TAPAV 1821
            ||         :||               .:|||....|.:|..  .|.||         .||.:
Human   561 EGSSRKQQPMENGGKSLPPTRRAPSSGDDQSSSSTQPPREVGTSNGRGFSHPLHCGGTPSQAPFL 625

  Fly  1822 R--KPAPPGPGEVKRGR----------------GRPRKQRDPVEEVKSQNPV----KRG--RGRP 1862
            .  :||.||.....||.                |.|.:||.|   ...|.||    .||  .|.|
Human   626 NQMRPAVPGTFGPLRGSDPATLYGSSGVPEPHPGEPVQQRQP---FTMQPPVGINSLRGPRLGTP 687

  Fly  1863 RKDSLASNMSHTQAYFLDEDLQCSTDDEDDDEEEDFQEVSEDENNAASIL-------DQGERINA 1920
            .:..:...::|                           :|....:..|:.       .|...:.|
Human   688 EEKQMCGGLTH---------------------------LSNMGPHPGSLQLGQISGPSQDGSMYA 725

  Fly  1921 PADAMDGMFDPKN-----------IKTEIDLEAHQMA---------------------EEPIGED 1953
            ||....|...|::           ..:||. .:|...                     :.|:|.|
Human   726 PAQFQPGFIPPRHGGAPARPPDFPESSEIP-PSHMYRSYKYLNRVHSAVWNGNHGATNQGPLGPD 789

  Fly  1954 DSQQVAEAMVQLSGVGGYYAQQQQDESMD-------VDPNY--DPSDFL---------------- 1993
            :...:        |.|..:..:.....||       |.||.  :.|.||
Human   790 EKPHL--------GPGPSHQPRTLGHVMDSRVMRPPVPPNQWTEQSGFLPHGVPSSGYMRPPCKS 846

  Fly  1994 AMHK-QRQSLGEPSSLQGAFTNFLSHEQDDNGPYNPAEASTSAASGADLGMDA--SMAMQMA--- 2052
            |.|: |...:..||||.||                ||:| .....|.|..||:  .:|||..
Human   847 AGHRLQPPPVPAPSSLFGA----------------PAQA-LRGVQGGDSMMDSPEMIAMQQLSSR 894

  Fly  2053 ---------PEMPVNTMNNG--MGIDDDLDISESDEEDDGSRVRIKKEVFDDGDYALQHQQMGQA 2106
                     |..|.:....|  ..:...:.::.|..:.                 ||.:.  |:|
Human   895 VCPPGVPYHPHQPAHPRLPGPFPQVAHPMSVTVSAPKP-----------------ALGNP--GRA 940

  Fly  2107 ASQSQIYMVDSSN-EPTTLDYQQPPQLDFQQVQEMEQLQHQVMPPMQSEQLQQQQTPQ 2163
            ...|:....::.. ||.....::||.:...:...:.||.|.. ||:|:: ..:|.:||
Human   941 PENSEAQEPENDQAEPLPGLEEKPPGVGTSEGVYLTQLPHPT-PPLQTD-CTRQSSPQ 996

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Taf1	NP_001246952.1	TBP-binding	15..76	CDD:286347
		DUF3591	652..1114	CDD:288969	39/183 (21%)
		zf-CCHC_6	1388..>1418	CDD:291934	0/29 (0%)
		Bromo_TFIID	1518..1629	CDD:99943	13/110 (12%)
		Bromo_TFIID	1640..1751	CDD:99943	30/110 (27%)
CECR2	NP_001276976.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	170..241		22/78 (28%)
		WHIM3	244..284	CDD:292248	10/56 (18%)
		Bromo_gcn5_like	418..518	CDD:99941	35/125 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	536..684		36/150 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	776..805		5/36 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	899..1033		22/119 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1145..1239
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1267..1300
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1422..1464
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D103411at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010