DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Taf1 and taf-1

DIOPT Version :9

Sequence 1:	NP_001246952.1	Gene:	Taf1 / 40813	FlyBaseID:	FBgn0010355	Length:	2172	Species:	Drosophila melanogaster
Sequence 2:	NP_493426.2	Gene:	taf-1 / 173257	WormBaseID:	WBGene00006382	Length:	1744	Species:	Caenorhabditis elegans

Alignment Length:	1963	Identity:	678/1963 - (34%)
Similarity:	962/1963 - (49%)	Gaps:	454/1963 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   200 NNSHF-------VAAKDDKELMPP-----------PSA---PMRSGSGGG-----IEEPAKSNDA 238
            ||:|.       ...|::::|..|           |:|   ...|.|.||     :|...:.|:.
Worm     2 NNTHHHTNGYRTEKPKNEEDLEDPYANLSDFYKNHPAARNEACSSASNGGSKSVKMEPKVEKNEE 66

  Fly   239 SSP--SDDSKSTDSKDADR---KLDTPLADILPSKYQNVDVRELFPDFRPQKVLRFSRLFGPG-K 297
            ...  .|..:..|.:...|   :.|.||:.||......:|.|..|.||.|.|.|||||||... |
Worm    67 FEEYIGDPVRLEDMEPFARPSLRDDAPLSSILHPDLDGIDPRIFFKDFNPNKTLRFSRLFAQNIK 131

  Fly   298 PTSLPQIW---RHVRKRRRKRNQSRDQKTTNTGGSDSPSDTEEP---------RKRGFSLHYAAE 350
            .||..:||   |...|.:||:                  :.|||         :|...::   .|
Worm   132 HTSRAEIWWASRTFSKHQRKK------------------EPEEPLADDVIVGAKKLKLNI---IE 175

  Fly   351 PTPAECMSDDEDKLLGDFNSEDVRPEGPDNGENSDQKPKVADWRFGPAQIWYDMLEVPDSGEGFN 415
            ..|...::|||::.:    ...:..:..:..:.:::...|..||.|||:|||||:.:|.:.:..|
Worm   176 KVPRVMLADDEEERM----RRPILTDAEEMAKKNEEGTVVQPWRTGPAKIWYDMMNLPMTSQAVN 236

  Fly   416 YGFKTKAA---------------------STSSQPQLKDERRVKSPE-----DDVE------DPS 448
            ||||.|.:                     ||||.|         :|.     |.||      :.|
Worm   237 YGFKLKKSPQKVSIRSGKPLNYRTPDDLPSTSSGP---------APNSAPFLDKVEVIDKSCEAS 292

  Fly   449 IADDAFLMVSQLHWEDDVVWDGNDIKAKVLQKLNSKTNAAGWLPSSGSRTAGAFSQPGKPSMPVG 513
            .::|..|....:.||:||:.||.::|.::|::. |.....||:|:..:||...|..
Worm   293 TSEDILLPYQVIEWENDVILDGEEVKDQLLEEF-SNGRGCGWIPTQYTRTYEHFVY--------- 347

  Fly   514 SGSSKQGSGASSKKAQQNAQAKPA----EAPDDT-----WYSLFPVENEELIYYKWEDEVIWDAQ 569
                    .|::...:|....|.|    ..||..     .:|:||....:|....||..:||||.
Worm   348 --------AANNNAFEQMFDGKSAPINLTGPDSAILPTPGHSIFPSAPCDLDILPWETNIIWDAD 404

  Fly   570 QVSKVPKPKVLTLDPNDENIILGIPDDIDPSKINKSTGPPPKIKIPHPH-----------VKKSK 623
            .:....:|....:|..|:.:|.|:|:|     .....||      .|.|           .||||
Worm   405 AMPSTLEPIDFLVDFQDDPLIYGMPED-----RRHDEGP------DHHHHHHHHRKDGQYTKKSK 458

  Fly   624 ILLGKAGVINVLAEDTPPPPPKS--PDRDPFNISNDTYYTPK-TEPTLRLKVGGN--LIQHSTPV 683
            ::||:........||.......:  .|.||||:|||.||.|| |..||    ..|  |||||||.
Worm   459 MILGQVQQRQKQEEDEQMESTMAQFTDNDPFNLSNDDYYVPKATSKTL----SNNSLLIQHSTPA 519

  Fly   684 VELRAPFVPTHMGPMKLRAFHRPPLKK--YSH-GPMA-QSIPHPVFPLLKTIAKKAKQREVERIA 744
            ..:...|.|||....:||.:||.|..:  ..| .||. |.|..||    |...:.|..||..|.|
Worm   520 TNIATHFFPTHPSAFRLRYWHRTPFTRRIVRHWQPMRFQPIQTPV----KHQQRVAAMREAMRQA 580

  Fly   745 SGGGDVFFMRNPEDLSGRDGDIVLAEFCEEHPPLINQVGMCSKIKNYYKRKAEKDSGPQDFVYGE 809
            .|||:||:||:.:||||:|..:|:.|:.||||.:::|.||.||:|||:||:...||.| .|.:||
Worm   581 QGGGEVFYMRDVQDLSGKDETLVMIEYSEEHPVILSQPGMASKMKNYFKRRQANDSEP-TFTFGE 644

  Fly   810 VAFAHTSPFLGILHPGQCIQAIENNMYRAPIYPHKMAHNDFLVIRTRNNYWIRSVNSIYTVGQEC 874
            :||:|..||||.|.|||.:|:|||.:||||||.||..:.|||:||:.|.::||.:.||:..||:|
Worm   645 LAFSHQIPFLGQLQPGQSLQSIENMLYRAPIYLHKRQNTDFLLIRSMNQWYIRPLPSIFVAGQQC 709

  Fly   875 PLYEVPGPNSKRANNFTRDFLQVFIYRLFWKSRDNPRRIRMDDIKQAFPAHSESSIRKRLKQCAD 939
            ||||||.||||||..|.||||..|||||||.|..:|||::|||::.|||.::||:||||||.|:.
Worm   710 PLYEVPSPNSKRATVFVRDFLFAFIYRLFWASDSSPRRLKMDDVRNAFPHYAESNIRKRLKMCST 774

  Fly   940 FKRTGMDSNWWVIKPEFRLPSEEEIRAMVSPEQCCAYFSMIAAEQRLKDAGYGEKFLFAPQEDDD 1004
            |.|.|.:: :|.:||:|||||:||:.:||:||.|||.:||:||||||||||||||:.|.|:.|:.
Worm   775 FVRQGSET-YWSLKPDFRLPSKEEVLSMVTPEMCCAQYSMMAAEQRLKDAGYGEKYFFTPENDEG 838

  Fly  1005 EEAQLKLDDEVKVAPWNTTRAYIQAMRGKCLLQLSGPADPTGCGEGFSYVRVPNKPTQTKEEQES 1069
            .|.::.::||:|.||||||||::.:.|.||||..:|.|||||||:|||||||..||  .|:|..:
Worm   839 SEDEVTIEDEIKCAPWNTTRAFLASQREKCLLDQTGIADPTGCGQGFSYVRVSQKP--HKDENAT 901

  Fly  1070 Q-PKRSVTGTDADLRRLPLQRAKELLRQFKVPEEEIKKLSRWEVIDVVRTLSTEKAKA---GE-- 1128
            . ||:.||||:||||:|||:.||::.|.:.|.||||..|:|||:|||:|||||:.|||   ||
Worm   902 PVPKKLVTGTNADLRKLPLKEAKQICRGYGVKEEEISALTRWEIIDVIRTLSTQAAKATKDGEII 966

  Fly  1129 --EGMDKFSRGN-RFSIAEHQERYKEECQRIFDLQNRVLASSEVLSTDEAESSASEESDLEELGK 1190
              .||.:|:||| |||.|:.||:|::.||||||.||:.||:::.:|||  :.|...:||.|||..
Worm   967 AVSGMARFARGNTRFSSADMQEKYRKHCQRIFDQQNQTLANTDPISTD--DDSTDADSDNEELAS 1029

  Fly  1191 NLENMLSNKKTSTQLSR--------EREELERQELLRQLDEEHG-------GPSGSGGAKGAKGK 1240
            .||:||...|....:|.        |.||.||::|.|.:   ||       |.....|...|:.|
Worm  1030 RLESMLEANKGKKNISMSEKAKIDFETEEKEREDLKRMI---HGTTNQVEKGEKKEEGEVTAEEK 1091

  Fly  1241 DDPGQ-----QMLATNNQG----RILRITRTFRGNDGKEYTRVETVRRQPVIDAYIKIRTTKDEQ 1296
            ....|     .|.|:...|    :.|:|.||.:|.|||:.||:|.|.|..:|:||.:||.|:|:.
Worm  1092 KSASQFGEDVAMSASKISGITANQQLKIYRTCKGPDGKDVTRIEIVTRPQLIEAYTRIRMTRDDT 1156

  Fly  1297 FIKQFATLDEQQKEEMKREKRRIQEQLRRIKRNQERERLAQLAQNQKLQPGGMPTSLGDPKSSGG 1361
            ||:.:|.:|||.|||.:::|||:|:|:||:|:|:|:.
Worm  1157 FIQVYAQMDEQYKEEKRKKKRRLQDQIRRMKKNEEKA---------------------------- 1193

  Fly  1362 HSHKERDSGYKEVSPSRKKFKLKPDL-KLKCGACGQVGHMRTNKACPLY------------SGMQ 1413
             :||.:....|:|.|.:..   .|:| |::|.||...|||:||:.||||            .|..
Worm  1194 -AHKVQKMTEKKVKPIKPP---NPNLQKMRCSACHAYGHMKTNRNCPLYGKDPLTPLKEEDEGST 1254

  Fly  1414 SSLSQSNPSLADDFDEQSEKEMTMDDDDLVNVDGTKV-----------------TLSSKILK--- 1458
            ...|.|:.||.              ..|.|.||||||                 .|..|:.|
Worm  1255 IMTSVSSASLV--------------APDAVQVDGTKVKFNLNFAEIRKEQNREEKLKRKLAKMAE 1305

  Fly  1459 ------------RHGG--------------------------DDGKR---RSGSSSGFTLKVPRD 1482
                        .:||                          ||..|   .||:||  .|..|..
Worm  1306 AAVRERQMAHLMEYGGGASSSGGAGGGGSGIGGSTGGGITDNDDDDRFSQISGTSS--FLNGPPG 1368

  Fly  1483 AM--GKKKRRVGGDLHC-------DYLQRHNKTANRRRTDPVVVLSSILEIIHNELRSMPDVSPF 1538
            |:  |.:...|.|....       ||||...|.|:|.|.||.||:||:|..|.|||:.:.....|
Worm  1369 AIRGGNRNSSVSGSKRRSSMMPEEDYLQGPLKVAHRARADPKVVMSSMLTDIVNELKMISGSDAF 1433

  Fly  1539 LFPVSAKKVPDYYRVVTKPMDLQTMREYIRQRRYTSREMFLEDLKQIVDNSLIYNGPQSAYTLAA 1603
            :.||::|||.|||.::..|:.||.:::.|.::.|..|:.||:|:|.:.|||.:|||..:..||.|
Worm  1434 VTPVNSKKVVDYYNIIKNPISLQEIKKKISEQSYLLRKDFLDDIKLMFDNSRMYNGDNNILTLTA 1498

  Fly  1604 QRMFSSCFELLAEREDKLMRLEKAINPLLDDDDQVALSFIFDKLHSQIKQLPESWPFLKPVNKKQ 1668
            |:|.....:.:.|||.|.:.|||.||||||.:|.:..|::..::..::|.:|:|..|...|:.|:
Worm  1499 QQMLQLAGKRMIEREQKFIGLEKQINPLLDTNDLIGFSYLLGEIVQKMKNIPKSALFHTRVDPKK 1563

  Fly  1669 VKDYYTVIKRPMDLETIGKNIEAHRYHSRAEYLADIELIATNCEQYNGSDTRYTKFSKKILEYAQ 1733
            :..||..|..||||..:.:..::..|.|..|:|.|.|.|.||...:||:::.|:..:|::.|.|:
Worm  1564 IPAYYLKISDPMDLSIMEQKSKSQEYKSIDEFLKDAEKIYTNSVVFNGAESVYSLKAKEMFEMAE 1628

  Fly  1734 TQLIEFSEHCGQLENNIAKTQERARENAPEFDEAWGNDDYNFDRGSRASSPGDDYID-VEGHGGH 1797
            ..:.:..:..|:||.||              :.:..||.....||....|  ||::| :|.|
Worm  1629 MLVKDQMDTLGELERNI--------------NPSAINDAAAAQRGLAMDS--DDHMDEMEDH--- 1674

  Fly  1798 ASSSNSIHRSMGAEAGSSHTAPAVRKPAPPGPGEVKRGRGRPRKQRDPVEEVKSQNPVKRGRGRP 1862
                                                           |.||.:.
Worm  1675 -----------------------------------------------PTEEEEE----------- 1681

  Fly  1863 RKDSLASNMSHTQAYFLDEDLQCSTDDEDDD------EEEDFQEVSEDENN-AASILDQGER--- 1917
                             |:|.:...||.|.|      :.:|...|.:..|: |.|..|:.||
Worm  1682 -----------------DDDDEIMDDDMDIDATGYSYDHDDNVAVGQIFNDLAMSDSDEDERAED 1729

  Fly  1918 INAPADAMDGMFD 1930
            :..||:..|.:.|
Worm  1730 VKRPANGDDNLLD 1742

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Taf1	NP_001246952.1	TBP-binding	15..76	CDD:286347
		DUF3591	652..1114	CDD:288969	255/469 (54%)
		zf-CCHC_6	1388..>1418	CDD:291934	14/41 (34%)
		Bromo_TFIID	1518..1629	CDD:99943	44/110 (40%)
		Bromo_TFIID	1640..1751	CDD:99943	33/110 (30%)
taf-1	NP_493426.2	DUF3591	489..947	CDD:288969	255/469 (54%)
		zf-CCHC_6	1217..1251	CDD:291934	13/33 (39%)
		Bromo_TFIID	1413..1524	CDD:99943	44/110 (40%)
		Bromo_TFIID	1535..1646	CDD:99943	34/124 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160164538
Domainoid	1	1.000	506	1.000	Domainoid score	I166
eggNOG	1	0.900	-	-		E1_COG5179
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37942
Inparanoid	1	1.050	948	1.000	Inparanoid score	I168
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46172
OrthoDB	1	1.010	-	-		D103411at2759
OrthoFinder	1	1.000	-	-		FOG0004441
OrthoInspector	1	1.000	-	-		oto19366
orthoMCL	1	0.900	-	-		OOG6_102499
Panther	1	1.100	-	-	LDO	PTHR13900
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2307
SonicParanoid	1	1.000	-	-		X3145
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.800