Protein Alignment Taf1 and TAF1L

DIOPT Version :10

• Sequence 1: NP_001246952.1
• Gene: Taf1 / 40813
• FlyBaseID: FBgn0010355
• Length: 2172
• Species: Drosophila melanogaster
• Sequence 2: NP_722516.1
• Gene: TAF1L / 138474
• HGNCID: 18056
• Length: 1826
• Species: Homo sapiens
• Alignment Length: 1995
• Identity: 926/1995 - (46%)
• Similarity: 1223/1995 - (61%)
• Gaps: 274/1995 - (13%)

  Fly     5 SDNSDDEGSIGNG-LDLTGILFGNIDSEGRLLQDDDGEGRGGTGFDAELRENIGSLSKLGLDSML 68
            ||:..:|.|.|.| ..|.|||||||...|:|        .|.:..|.|.::::..|..|||.|::
Human    21 SDSDSEEDSSGGGPFTLAGILFGNISGAGQL--------EGESVLDDECKKHLAGLGALGLGSLI 77

  Fly    69 LEVIDLKEAEPPSDDEEEEDARPSAVSASEGMSAFDALKAGVKREDGAVKAQDDAIDYSDITELS 133
            .|                       ::|:|.::   .....:..::|.:::.:||:|||||.|::
Human    78 TE-----------------------LTANEELT---GTGGALVNDEGWIRSTEDAVDYSDINEVA 116

  Fly   134 ED--------CPRTPPEETSTYDDLEDAIPASKVEAKLREDIAQIFKGLCNSCQSDTITFAPLRL 190
            ||        .....|...|.||  ||...|.      .|||
Human   117 EDESQRHQQTMGSLQPLYHSDYD--EDDYDAD------CEDI----------------------- 150

  Fly   191 GSDLLLYRENNSHFVAAKDDKELM---PPPSAPMR-----------SGSGGGIEEP--------- 232
                               |.:||   |||..||:           |.||..|..|
Human   151 -------------------DCKLMPPPPPPPGPMKKDKDQDAITCVSESGEDIILPSIIAPSFLA 196

  Fly   233 AKSNDASSPSDD------SKSTDSKDADRKLDTPLADI--------LPSKYQNVDVRELFPDFRP 283
            ::..|.||.||.      .::|.::..|.||..|||.|        |||      |.||||:|||
Human   197 SEKVDFSSYSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDATKLLPS------VTELFPEFRP 255

  Fly   284 QKVLRFSRLFGPGKPTSLPQIWRHVRKRRRKRNQSRDQKTTNTGGSDSPSDTEEPRKRGFSLHYA 348
            .|||||..||||||  ::|.:||..|::|:|..:...::....  .:...::|..:|..::..||
Human   256 GKVLRFLHLFGPGK--NVPSVWRSARRKRKKHRELIQEEQIQE--VECSVESEVSQKSLWNYDYA 316

  Fly   349 AEPTPAECMSDDEDKLLGDFNSEDVRPEGPDNGENSDQKPKVADWRFGPAQIWYDMLEVPDSGEG 413
            ..|.|.:|::|||..::....|:..:..| |..:.:|.||:||:||:|||::|||||.|.:.|.|
Human   317 PPPPPEQCLADDEITMMVPVESKFSQSTG-DVDKVTDTKPRVAEWRYGPARLWYDMLGVSEDGSG 380

  Fly   414 FNYGFKTKAASTSSQPQLKD---ERRVKSPEDDVEDPSIADDAFLMVSQLHWEDDVVWDGNDIKA 475
            |:||||.:  .|..:|.:|.   |...|..|.:..| .:||:.||||:||||||.::|||.|||.
Human   381 FDYGFKLR--KTQHEPVIKSRMMEEFRKLEESNGTD-LLADENFLMVTQLHWEDSIIWDGEDIKH 442

  Fly   476 KVLQKLNSKTNAAGWLPSSGSRTAGAFSQPGKPSMPVGSGSSKQGSGASSKKAQQNAQAKPAEAP 540
            |..:...:  :.||||||..:|...|:             :.:||..             |....
Human   443 KGTKPQGA--SLAGWLPSIKTRNVMAY-------------NVQQGFA-------------PTLDD 479

  Fly   541 DDTWYSLFPVENEELIYYKWEDEVIWDAQQVSKVPKPKVLTLDPNDENIILGIPDDIDPSKINKS 605
            |..|||:||::||:|:|.:|||.:|||||.:.::.:|.||.|||||||:||.|||:    |...:
Human   480 DKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLALDPNDENLILEIPDE----KEEAT 540

  Fly   606 TGPPPKIKIPHPHVKKSKILLGKAGVINVLAEDTPPPPPKSPD-RDPFNISNDTYYTPKTEPTLR 669
            :..|.|.......:|||:|||||.|||    .:.|......|: :||:|:|||.||.|| :..||
Human   541 SNSPSKESKKESSLKKSRILLGKTGVI----REEPQQNMSQPEVKDPWNLSNDEYYFPK-QQGLR 600

  Fly   670 LKVGGNLIQHSTPVVELRAPFVPTHMGPMKLRAFHRPPLKKYSHGPMAQSIPHPVFPLLKTIAKK 734
            ...|||:||||.|.:||..||.||||||:|:|.||||||||||.|.::|..||.|.||||.|.||
Human   601 GTFGGNIIQHSIPAMELWQPFFPTHMGPIKIRQFHRPPLKKYSFGALSQPGPHSVQPLLKHIKKK 665

  Fly   735 AKQREVERIASGGGDVFFMRNPEDLSGRDGDIVLAEFCEEHPPLINQVGMCSKIKNYYKRKAEKD 799
            ||.||.||.|||||::||||.|:||:|:|||::|||:.||:.||:.||||.:|||||||||..||
Human   666 AKMREQERQASGGGELFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATKIKNYYKRKPGKD 730

  Fly   800 SGPQDFVYGEVAFAHTSPFLGILHPGQCIQAIENNMYRAPIYPHKMAHNDFLVIRTRNNYWIRSV 864
            .|..|..|||..:.|||||||.|||||.:||:|||::|||:|.|||...|||:||||..|:||.:
Human   731 PGAPDCKYGETVYCHTSPFLGSLHPGQLLQALENNLFRAPVYLHKMPETDFLIIRTRQGYYIREL 795

  Fly   865 NSIYTVGQECPLYEVPGPNSKRANNFTRDFLQVFIYRLFWKSRDNPRRIRMDDIKQAFPAHSESS 929
            ..|:.|||:|||:|||||||:|||...|||||||||||||||:|.||||||:|||:|||:|||||
Human   796 VDIFVVGQQCPLFEVPGPNSRRANMHIRDFLQVFIYRLFWKSKDRPRRIRMEDIKKAFPSHSESS 860

  Fly   930 IRKRLKQCADFKRTGMDSNWWVIKPEFRLPSEEEIRAMVSPEQCCAYFSMIAAEQRLKDAGYGEK 994
            ||||||.|||||||||||||||:|.:||||:||||||.|||||||||:|||||:|||||||||||
Human   861 IRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAKVSPEQCCAYYSMIAAKQRLKDAGYGEK 925

  Fly   995 FLFAPQEDDDEEAQLKLDDEVKVAPWNTTRAYIQAMRGKCLLQLSGPADPTGCGEGFSYVRVPNK 1059
            ..|||:|:::|:.|:|:||||..||||||||:|.||:|||||:::|.|||||||||||||::|||
Human   926 SFFAPEEENEEDFQMKIDDEVHAAPWNTTRAFIAAMKGKCLLEVTGVADPTGCGEGFSYVKIPNK 990

  Fly  1060 PTQTKEEQESQP-KRSVTGTDADLRRLPLQRAKELLRQFKVPEEEIKKLSRWEVIDVVRTLSTEK 1123
            |||.|:::|.|. |::|||||||||||.|:.||:|||:|.||||||||||||||||||||:|||:
Human   991 PTQQKDDKEPQAVKKTVTGTDADLRRLSLKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQ 1055

  Fly  1124 AKAGEEGMDKFSRGNRFSIAEHQERYKEECQRIFDLQNRVLASSEVLSTDEAESSASEESDLEEL 1188
            |.:||..|.||:||:|||:|||||||||||||||||||:||:|:|||||| .:|.::|:||.||:
Human  1056 AHSGEGPMSKFARGSRFSVAEHQERYKEECQRIFDLQNKVLSSTEVLSTD-TDSISAEDSDFEEM 1119

  Fly  1189 GKNLENMLSNKKTSTQLSREREELERQELLRQLDEEHGGPSGSGGAKGAKGKDDPGQQM--LATN 1251
            |||:||||.|||||:|||||.||.||:||.|.|     ..:|| .|.|...:||....|  |.::
Human  1120 GKNIENMLQNKKTSSQLSREWEEQERKELRRML-----LVAGS-AASGNNHRDDVTASMTSLKSS 1178

  Fly  1252 NQGRILRITRTFRGNDGKEYTRVETVRRQPVIDAYIKIRTTKDEQFIKQFATLDEQQKEEMKREK 1316
            ..|..|:|.||||..:||||.|.||||:..|||||::|||||||:||::||..||:.:|||::|:
Human  1179 ATGHCLKIYRTFRDEEGKEYVRCETVRKPAVIDAYVRIRTTKDEKFIQKFALFDEKHREEMRKER 1243

  Fly  1317 RRIQEQLRRIKRNQERERLAQLAQNQKLQPGGMPTSLGDPKSSGGHSHKERDSGYKEVSPSRKKF 1381
            |||||||||:|||||:|:|                                 .|..|..|  ||.
Human  1244 RRIQEQLRRLKRNQEKEKL---------------------------------KGPPEKKP--KKM 1273

  Fly  1382 KLKPDLKLKCGACGQVGHMRTNKACPLYSGMQSSLSQSNP-SLADDFDEQSEKEMT-MDDDDLVN 1444
            |.:|||||||||||.:|||||||.||||  .|:::..|.| ::.::.:|:.||.:. .|:::|:.
Human  1274 KERPDLKLKCGACGAIGHMRTNKFCPLY--YQTNVPPSKPVAMTEEQEEELEKTVIHNDNEELIK 1336

  Fly  1445 VDGTKVTLSSKILKR-HGGDDGKRRSGSSSGFTLKVPRDAM-GKKKRRVGGDLHCDYLQRHNKTA 1507
            |:|||:....::::. |   :.:|:|     ..||.|:..: .|||||||..:|||||...:|:.
Human  1337 VEGTKIVFGKQLIENVH---EVRRKS-----LVLKFPKQQLPPKKKRRVGTTVHCDYLNIPHKSI 1393

  Fly  1508 NRRRTDPVVVLSSILEIIHNELRSMPDVSPFLFPVSAKKVPDYYRVVTKPMDLQTMREYIRQRRY 1572
            :||||||:|.||||||.|.|::|.:|:..||..||:||.|.|||:::|:||||||:||.:|:..|
Human  1394 HRRRTDPMVTLSSILESIINDMRDLPNTHPFHTPVNAKVVKDYYKIITRPMDLQTLRENVRKCLY 1458

  Fly  1573 TSREMFLEDLKQIVDNSLIYNGPQSAYTLAAQRMFSSCFELLAEREDKLMRLEKAINPLLDDDDQ 1637
            .|||.|.|.|:.||.||..||||:.:.|..:|.|...|.|.|.|:||||.|||||||||||||||
Human  1459 PSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDEKLKEKEDKLARLEKAINPLLDDDDQ 1523

  Fly  1638 VALSFIFDKLHSQ-IKQLPESWPFLKPVNKKQVKDYYTVIKRPMDLETIGKNIEAHRYHSRAEYL 1701
            ||.|||.|.:.:| :..:|:||||..|||||.|.|||.:|..|:|||||.|||..|:|.||..:|
Human  1524 VAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPDYYKMIVNPVDLETIRKNISKHKYQSRESFL 1588

  Fly  1702 ADIELIATNCEQYNGSDTRYTKFSKKILEYAQTQLIEFSEHCGQLENNIAKTQERARENAPEFDE 1766
            .|:.||..|..:|||.:::|||.:::|:......:.|:.||..|||.:|...:|.|.|.|    |
Human  1589 DDVNLILANSVKYNGPESQYTKTAQEIVNICYQTITEYDEHLTQLEKDICTAKEAALEEA----E 1649

  Fly  1767 AWGNDDYNFDRGSRASSPGDDYIDVEGHGGHASSSNSIHRSMGAEAGSSHTAPAVRKPAPPGPGE 1831
            ....|.  ...|...|.|.|.|        ..::|.|..|........|:.:......|.| ..:
Human  1650 LESLDP--MTPGPYTSQPPDMY--------DTNTSLSTSRDASVFQDESNLSVLDISTATP-EKQ 1703

  Fly  1832 VKRGRGRPRKQ---------RDPVEEVKSQNPVKRGRGRPRKDSLASNMSHTQAYFLDEDLQCST 1887
            :.:|:||..::         .|..|:.|.:.|...|......|.....:...:|..|.|||..|
Human  1704 MCQGQGRLGEEDSDVDVEGYDDEEEDGKPKPPAPEGGDGDLADEEEGTVQQPEASVLYEDLLIS- 1767

  Fly  1888 DDEDDDEEEDFQEVSEDENNAASILDQGERINAPADAMDGMFDPK 1932
            :.|||:|:....|..::..:|..:.:.|    :.:|...|...||
Human  1768 EGEDDEEDAGSDEEGDNPFSAIQLSESG----SDSDVGYGGIRPK 1808

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Taf1	NP_001246952.1	TBP-binding	8..76	CDD:462723	23/68 (34%)
		DUF3591	652..1115	CDD:463476	326/463 (70%)
		zf-CCHC_6	1388..>1418	CDD:464616	20/29 (69%)
		Bromo_TFIID	1518..1629	CDD:99943	61/110 (55%)
		Bromo_TFIID	1640..1751	CDD:99943	51/111 (46%)
TAF1L	NP_722516.1	TBP-binding	34..85	CDD:462723	20/81 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	118..141		5/24 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	532..555		6/26 (23%)
		DUF3591	584..1047	CDD:463476	326/463 (70%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1252..1276		14/58 (24%)
		zf-CCHC_6	1280..1315	CDD:464616	22/36 (61%)
		Nuclear localization signal. /evidence=ECO:0000255	1370..1377		4/6 (67%)
		Bromo_TFIID	1404..1515	CDD:99943	61/110 (55%)
		Bromo_TFIID	1526..1638	CDD:99943	51/111 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1648..1826		40/181 (22%)
		CobT2	<1711..>1821	CDD:443611	23/103 (22%)