DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Taf1 and TAF1L

DIOPT Version :9

Sequence 1:	NP_001246952.1	Gene:	Taf1 / 40813	FlyBaseID:	FBgn0010355	Length:	2172	Species:	Drosophila melanogaster
Sequence 2:	NP_722516.1	Gene:	TAF1L / 138474	HGNCID:	18056	Length:	1826	Species:	Homo sapiens

Alignment Length:	1995	Identity:	926/1995 - (46%)
Similarity:	1223/1995 - (61%)	Gaps:	274/1995 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SDNSDDEGSIGNG-LDLTGILFGNIDSEGRLLQDDDGEGRGGTGFDAELRENIGSLSKLGLDSML 68
            ||:..:|.|.|.| ..|.|||||||...|:|        .|.:..|.|.::::..|..|||.|::
Human    21 SDSDSEEDSSGGGPFTLAGILFGNISGAGQL--------EGESVLDDECKKHLAGLGALGLGSLI 77

  Fly    69 LEVIDLKEAEPPSDDEEEEDARPSAVSASEGMSAFDALKAGVKREDGAVKAQDDAIDYSDITELS 133
            .|                       ::|:|.::   .....:..::|.:::.:||:|||||.|::
Human    78 TE-----------------------LTANEELT---GTGGALVNDEGWIRSTEDAVDYSDINEVA 116

  Fly   134 ED--------CPRTPPEETSTYDDLEDAIPASKVEAKLREDIAQIFKGLCNSCQSDTITFAPLRL 190
            ||        .....|...|.||  ||...|.      .|||
Human   117 EDESQRHQQTMGSLQPLYHSDYD--EDDYDAD------CEDI----------------------- 150

  Fly   191 GSDLLLYRENNSHFVAAKDDKELM---PPPSAPMR-----------SGSGGGIEEP--------- 232
                               |.:||   |||..||:           |.||..|..|
Human   151 -------------------DCKLMPPPPPPPGPMKKDKDQDAITCVSESGEDIILPSIIAPSFLA 196

  Fly   233 AKSNDASSPSDD------SKSTDSKDADRKLDTPLADI--------LPSKYQNVDVRELFPDFRP 283
            ::..|.||.||.      .::|.::..|.||..|||.|        |||      |.||||:|||
Human   197 SEKVDFSSYSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDATKLLPS------VTELFPEFRP 255

  Fly   284 QKVLRFSRLFGPGKPTSLPQIWRHVRKRRRKRNQSRDQKTTNTGGSDSPSDTEEPRKRGFSLHYA 348
            .|||||..||||||  ::|.:||..|::|:|..:...::....  .:...::|..:|..::..||
Human   256 GKVLRFLHLFGPGK--NVPSVWRSARRKRKKHRELIQEEQIQE--VECSVESEVSQKSLWNYDYA 316

  Fly   349 AEPTPAECMSDDEDKLLGDFNSEDVRPEGPDNGENSDQKPKVADWRFGPAQIWYDMLEVPDSGEG 413
            ..|.|.:|::|||..::....|:..:..| |..:.:|.||:||:||:|||::|||||.|.:.|.|
Human   317 PPPPPEQCLADDEITMMVPVESKFSQSTG-DVDKVTDTKPRVAEWRYGPARLWYDMLGVSEDGSG 380

  Fly   414 FNYGFKTKAASTSSQPQLKD---ERRVKSPEDDVEDPSIADDAFLMVSQLHWEDDVVWDGNDIKA 475
            |:||||.:  .|..:|.:|.   |...|..|.:..| .:||:.||||:||||||.::|||.|||.
Human   381 FDYGFKLR--KTQHEPVIKSRMMEEFRKLEESNGTD-LLADENFLMVTQLHWEDSIIWDGEDIKH 442

  Fly   476 KVLQKLNSKTNAAGWLPSSGSRTAGAFSQPGKPSMPVGSGSSKQGSGASSKKAQQNAQAKPAEAP 540
            |..:...:  :.||||||..:|...|:             :.:||..             |....
Human   443 KGTKPQGA--SLAGWLPSIKTRNVMAY-------------NVQQGFA-------------PTLDD 479

  Fly   541 DDTWYSLFPVENEELIYYKWEDEVIWDAQQVSKVPKPKVLTLDPNDENIILGIPDDIDPSKINKS 605
            |..|||:||::||:|:|.:|||.:|||||.:.::.:|.||.|||||||:||.|||:    |...:
Human   480 DKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLALDPNDENLILEIPDE----KEEAT 540

  Fly   606 TGPPPKIKIPHPHVKKSKILLGKAGVINVLAEDTPPPPPKSPD-RDPFNISNDTYYTPKTEPTLR 669
            :..|.|.......:|||:|||||.|||    .:.|......|: :||:|:|||.||.|| :..||
Human   541 SNSPSKESKKESSLKKSRILLGKTGVI----REEPQQNMSQPEVKDPWNLSNDEYYFPK-QQGLR 600

  Fly   670 LKVGGNLIQHSTPVVELRAPFVPTHMGPMKLRAFHRPPLKKYSHGPMAQSIPHPVFPLLKTIAKK 734
            ...|||:||||.|.:||..||.||||||:|:|.||||||||||.|.::|..||.|.||||.|.||
Human   601 GTFGGNIIQHSIPAMELWQPFFPTHMGPIKIRQFHRPPLKKYSFGALSQPGPHSVQPLLKHIKKK 665

  Fly   735 AKQREVERIASGGGDVFFMRNPEDLSGRDGDIVLAEFCEEHPPLINQVGMCSKIKNYYKRKAEKD 799
            ||.||.||.|||||::||||.|:||:|:|||::|||:.||:.||:.||||.:|||||||||..||
Human   666 AKMREQERQASGGGELFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATKIKNYYKRKPGKD 730

  Fly   800 SGPQDFVYGEVAFAHTSPFLGILHPGQCIQAIENNMYRAPIYPHKMAHNDFLVIRTRNNYWIRSV 864
            .|..|..|||..:.|||||||.|||||.:||:|||::|||:|.|||...|||:||||..|:||.:
Human   731 PGAPDCKYGETVYCHTSPFLGSLHPGQLLQALENNLFRAPVYLHKMPETDFLIIRTRQGYYIREL 795

  Fly   865 NSIYTVGQECPLYEVPGPNSKRANNFTRDFLQVFIYRLFWKSRDNPRRIRMDDIKQAFPAHSESS 929
            ..|:.|||:|||:|||||||:|||...|||||||||||||||:|.||||||:|||:|||:|||||
Human   796 VDIFVVGQQCPLFEVPGPNSRRANMHIRDFLQVFIYRLFWKSKDRPRRIRMEDIKKAFPSHSESS 860

  Fly   930 IRKRLKQCADFKRTGMDSNWWVIKPEFRLPSEEEIRAMVSPEQCCAYFSMIAAEQRLKDAGYGEK 994
            ||||||.|||||||||||||||:|.:||||:||||||.|||||||||:|||||:|||||||||||
Human   861 IRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAKVSPEQCCAYYSMIAAKQRLKDAGYGEK 925

  Fly   995 FLFAPQEDDDEEAQLKLDDEVKVAPWNTTRAYIQAMRGKCLLQLSGPADPTGCGEGFSYVRVPNK 1059
            ..|||:|:::|:.|:|:||||..||||||||:|.||:|||||:::|.|||||||||||||::|||
Human   926 SFFAPEEENEEDFQMKIDDEVHAAPWNTTRAFIAAMKGKCLLEVTGVADPTGCGEGFSYVKIPNK 990

  Fly  1060 PTQTKEEQESQP-KRSVTGTDADLRRLPLQRAKELLRQFKVPEEEIKKLSRWEVIDVVRTLSTEK 1123
            |||.|:::|.|. |::|||||||||||.|:.||:|||:|.||||||||||||||||||||:|||:
Human   991 PTQQKDDKEPQAVKKTVTGTDADLRRLSLKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQ 1055

  Fly  1124 AKAGEEGMDKFSRGNRFSIAEHQERYKEECQRIFDLQNRVLASSEVLSTDEAESSASEESDLEEL 1188
            |.:||..|.||:||:|||:|||||||||||||||||||:||:|:|||||| .:|.::|:||.||:
Human  1056 AHSGEGPMSKFARGSRFSVAEHQERYKEECQRIFDLQNKVLSSTEVLSTD-TDSISAEDSDFEEM 1119

  Fly  1189 GKNLENMLSNKKTSTQLSREREELERQELLRQLDEEHGGPSGSGGAKGAKGKDDPGQQM--LATN 1251
            |||:||||.|||||:|||||.||.||:||.|.|     ..:|| .|.|...:||....|  |.::
Human  1120 GKNIENMLQNKKTSSQLSREWEEQERKELRRML-----LVAGS-AASGNNHRDDVTASMTSLKSS 1178

  Fly  1252 NQGRILRITRTFRGNDGKEYTRVETVRRQPVIDAYIKIRTTKDEQFIKQFATLDEQQKEEMKREK 1316
            ..|..|:|.||||..:||||.|.||||:..|||||::|||||||:||::||..||:.:|||::|:
Human  1179 ATGHCLKIYRTFRDEEGKEYVRCETVRKPAVIDAYVRIRTTKDEKFIQKFALFDEKHREEMRKER 1243

  Fly  1317 RRIQEQLRRIKRNQERERLAQLAQNQKLQPGGMPTSLGDPKSSGGHSHKERDSGYKEVSPSRKKF 1381
            |||||||||:|||||:|:|                                 .|..|..|  ||.
Human  1244 RRIQEQLRRLKRNQEKEKL---------------------------------KGPPEKKP--KKM 1273

  Fly  1382 KLKPDLKLKCGACGQVGHMRTNKACPLYSGMQSSLSQSNP-SLADDFDEQSEKEMT-MDDDDLVN 1444
            |.:|||||||||||.:|||||||.||||  .|:::..|.| ::.::.:|:.||.:. .|:::|:.
Human  1274 KERPDLKLKCGACGAIGHMRTNKFCPLY--YQTNVPPSKPVAMTEEQEEELEKTVIHNDNEELIK 1336

  Fly  1445 VDGTKVTLSSKILKR-HGGDDGKRRSGSSSGFTLKVPRDAM-GKKKRRVGGDLHCDYLQRHNKTA 1507
            |:|||:....::::. |   :.:|:|     ..||.|:..: .|||||||..:|||||...:|:.
Human  1337 VEGTKIVFGKQLIENVH---EVRRKS-----LVLKFPKQQLPPKKKRRVGTTVHCDYLNIPHKSI 1393

  Fly  1508 NRRRTDPVVVLSSILEIIHNELRSMPDVSPFLFPVSAKKVPDYYRVVTKPMDLQTMREYIRQRRY 1572
            :||||||:|.||||||.|.|::|.:|:..||..||:||.|.|||:::|:||||||:||.:|:..|
Human  1394 HRRRTDPMVTLSSILESIINDMRDLPNTHPFHTPVNAKVVKDYYKIITRPMDLQTLRENVRKCLY 1458

  Fly  1573 TSREMFLEDLKQIVDNSLIYNGPQSAYTLAAQRMFSSCFELLAEREDKLMRLEKAINPLLDDDDQ 1637
            .|||.|.|.|:.||.||..||||:.:.|..:|.|...|.|.|.|:||||.|||||||||||||||
Human  1459 PSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDEKLKEKEDKLARLEKAINPLLDDDDQ 1523

  Fly  1638 VALSFIFDKLHSQ-IKQLPESWPFLKPVNKKQVKDYYTVIKRPMDLETIGKNIEAHRYHSRAEYL 1701
            ||.|||.|.:.:| :..:|:||||..|||||.|.|||.:|..|:|||||.|||..|:|.||..:|
Human  1524 VAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPDYYKMIVNPVDLETIRKNISKHKYQSRESFL 1588

  Fly  1702 ADIELIATNCEQYNGSDTRYTKFSKKILEYAQTQLIEFSEHCGQLENNIAKTQERARENAPEFDE 1766
            .|:.||..|..:|||.:::|||.:::|:......:.|:.||..|||.:|...:|.|.|.|    |
Human  1589 DDVNLILANSVKYNGPESQYTKTAQEIVNICYQTITEYDEHLTQLEKDICTAKEAALEEA----E 1649

  Fly  1767 AWGNDDYNFDRGSRASSPGDDYIDVEGHGGHASSSNSIHRSMGAEAGSSHTAPAVRKPAPPGPGE 1831
            ....|.  ...|...|.|.|.|        ..::|.|..|........|:.:......|.| ..:
Human  1650 LESLDP--MTPGPYTSQPPDMY--------DTNTSLSTSRDASVFQDESNLSVLDISTATP-EKQ 1703

  Fly  1832 VKRGRGRPRKQ---------RDPVEEVKSQNPVKRGRGRPRKDSLASNMSHTQAYFLDEDLQCST 1887
            :.:|:||..::         .|..|:.|.:.|...|......|.....:...:|..|.|||..|
Human  1704 MCQGQGRLGEEDSDVDVEGYDDEEEDGKPKPPAPEGGDGDLADEEEGTVQQPEASVLYEDLLIS- 1767

  Fly  1888 DDEDDDEEEDFQEVSEDENNAASILDQGERINAPADAMDGMFDPK 1932
            :.|||:|:....|..::..:|..:.:.|    :.:|...|...||
Human  1768 EGEDDEEDAGSDEEGDNPFSAIQLSESG----SDSDVGYGGIRPK 1808

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Taf1	NP_001246952.1	TBP-binding	15..76	CDD:286347	21/61 (34%)
		DUF3591	652..1114	CDD:288969	325/462 (70%)
		zf-CCHC_6	1388..>1418	CDD:291934	20/29 (69%)
		Bromo_TFIID	1518..1629	CDD:99943	61/110 (55%)
		Bromo_TFIID	1640..1751	CDD:99943	51/111 (46%)
TAF1L	NP_722516.1	TBP-binding	34..85	CDD:286347	20/81 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	118..141		5/24 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	532..555		6/26 (23%)
		DUF3591	584..1046	CDD:288969	325/462 (70%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1252..1276		14/58 (24%)
		zf-CCHC_6	1280..1315	CDD:291934	22/36 (61%)
		Nuclear localization signal. /evidence=ECO:0000255	1370..1377		4/6 (67%)
		Bromo_TFIID	1404..1515	CDD:99943	61/110 (55%)
		Bromo_TFIID	1526..1638	CDD:99943	51/111 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1648..1826		40/181 (22%)
		ASF1_hist_chap	<1713..1798	CDD:304562	19/89 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156497
Domainoid	1	1.000	706	1.000	Domainoid score	I123
eggNOG	1	0.900	-	-		E1_COG5179
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1656	1.000	Inparanoid score	I79
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46172
OrthoDB	1	1.010	-	-		D103411at2759
OrthoFinder	1	1.000	-	-		FOG0004441
OrthoInspector	1	1.000	-	-		otm40291
orthoMCL	1	0.900	-	-		OOG6_102499
Panther	1	1.100	-	-	O	PTHR13900
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2307
SonicParanoid	1	1.000	-	-		X3145
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800