DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Taf1 and cecr2

DIOPT Version :9

Sequence 1:	NP_001246952.1	Gene:	Taf1 / 40813	FlyBaseID:	FBgn0010355	Length:	2172	Species:	Drosophila melanogaster
Sequence 2:	XP_031754453.1	Gene:	cecr2 / 100486642	XenbaseID:	XB-GENE-6461178	Length:	1235	Species:	Xenopus tropicalis

Alignment Length:	1380	Identity:	243/1380 - (17%)
Similarity:	385/1380 - (27%)	Gaps:	528/1380 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly  1088 QRAKELLRQFKVPEEEIKKLSRWEVIDVVRTLSTEKAKAGEEGMDKFSRGNRFSIAEHQER---- 1148
            ||....|:.|.|..|:|... |||:               |||.....||..|...|.:.|
Frog    65 QRRDITLQTFHVYLEDIISY-RWEM---------------EEGKPNPLRGTTFHQLELRTRLEIL 113

  Fly  1149 -----YKEECQRIFDLQNRVLASSEVLSTDEAESSASEESDLEELGKNLENMLSNKKTSTQLSRE 1208
                 |:.:...:|||               .:....:...:|.||::....|......|:|.:|
Frog   114 HRLCDYRLDADDVFDL---------------LKGLDGDSLRVEPLGEDSSGNLYWYFYGTRLYKE 163

  Fly  1209 REELE-RQELLRQLDEEHGGPSGSGGAKGAKGKD-----------DP------------------ 1243
            ....| ||.||.|..:....|....|....|.|.           ||
Frog   164 EPSWEKRQRLLEQASKNQEKPVRKRGRPPKKKKPVEEELLLSEKMDPKPPVVDEISDMKGCSPGE 228

  Fly  1244 GQQMLATNNQGRILRITRTFRGNDGKEYTRVETVRRQPVIDAYIKIRTTKDEQFIKQFATLDEQQ 1308
            |...|....:.....:|.:||       .:|....||        :.....|:|:.:...:..|:
Frog   229 GSWSLLCQTEQEWREVTDSFR-------DKVSHNERQ--------LYKLLSEEFLPEICNMISQK 278

  Fly  1309 KEEMKREKRRIQEQLRRIKRNQERERLAQLAQNQKLQPGGMPTSLGDPKSS----GGHSHKERDS 1369
            :.::::|:..|..     ||..||                  :.|.||:..    |||...|...
Frog   279 ETKIQKEQAEIAS-----KRLSER------------------SGLRDPEQDHNPLGGHEGDEERR 320

  Fly  1370 GYKEVSPSRKKFKLKPDLKLKCGA-------CGQVGHMRTNKACPLYSGMQSSLSQSNPSLADDF 1427
            ....|....::.:||.:.|.....       ..|...:|..:|..|..|     .|..|.|
Frog   321 LLLAVQRKEQELRLKEERKRAMAERVKSVEDRAQRRKLREERAWLLSQG-----KQLPPEL---- 376

  Fly  1428 DEQSEKEMTMDDDDLVNVDGTKVTLSSKILKRHGGDDGKRRSGSSSGFTLKVPRDAMGKKKRRVG 1492
             ...|....::.|     .||
Frog   377 -RHLEPRSPVETD-----YGT-------------------------------------------- 391

  Fly  1493 GDLHCDYLQRHNKTANRRRTDPVVVLSSILEIIHNELRSMPDVSPFLFPVSAKKVPDYYRVVTKP 1557
            |||....|..|           ...:..:|:.:    ::..|..|||.||.....|:||.::|.|
Frog   392 GDLFSFELDDH-----------YTAMYKVLDAV----KAHKDSWPFLEPVDESYAPNYYNIITCP 441

  Fly  1558 MDLQTMREYIRQRRYTSREMFLEDLKQIVDNSLIYNGPQSAYTLAAQRMFSSCFELLAEREDKLM 1622
            |||..:.:.:....|.::|.|:.|:|.|..|...|||..|.||..|..: ..||
Frog   442 MDLSRVEQRLCSGYYLTKEQFVNDMKIIFKNCAKYNGQDSEYTEMADNL-ERCF----------- 494

  Fly  1623 RLEKAINPLLDDDDQVALSFIFDKLHSQIKQLP--------ESWPFLKPVNKKQVKDYYTVIKRP 1679
              :||:                      :|.||        |:|..   |.:|:         ||
Frog   495 --KKAM----------------------LKHLPEDEGESDGETWIH---VEEKE---------RP 523

  Fly  1680 MDLETIGK------------NIEAHRYHSRAEYLADIELIATNCEQYNGSDTRYTKFSKKI---- 1728
            :..:::|:            :.|..|..|.:...:.........|::.|.....:.:..::
Frog   524 LKRKSLGRRSKVGGWQKSRDDSERKRQSSESSRASPSTPRQEESERHYGPPAMASPYPHQLHYGG 588

  Fly  1729 ---------------------------LEYAQTQLIEFSEHCGQLENNIAKTQERARENAPEFDE 1766
                                       |.|.   .:.|.|  .||.:.:.:||....:.:|:..|
Frog   589 MARQSLHPRDMPSAPGMQAPLRSSEPGLSYG---ALRFPE--PQLGDPVQQTQSYRTQASPDVPE 648

  Fly  1767 AWGNDDYNF--DRG-------SRASSPG-------------------------DDYIDVEGHGG- 1796
            |..::..||  .||       :|.|.|.                         |..:..:|.|.
Frog   649 ASDSNPANFRHSRGPHVPPNSARMSGPSQEGGRLYPQAQYPMGYMPQMRPGLPDGRVPPQGPGSA 713

  Fly  1797 -------------------------------------------HASSSNSIH-----------RS 1807
                                                       ..|:.||:.           .|
Frog   714 PFQLGQPSAAWNGNCPPRPQQYGAPMDPRMVRPPDSVCNGRNTFGSAGNSMMDSPEMVAMQRLSS 778

  Fly  1808 MGAEAGSSHTAPAVRKPAPP--GPGEVKRGRGRPRKQRDPVEEVKSQNPVKR----GRGRPRKDS 1866
            :.....|::..|....|.||  .||.:   .|....|...|...|:..|..:    |..:|:...
Frog   779 LSGPPSSAYPLPLGPAPYPPSGAPGTM---NGPDMCQPSAVNRAKTTAPGDKASSPGDSKPKSPP 840

  Fly  1867 LASNMSHTQAYFLDED-----LQCSTDDEDD-------DEEEDFQEVSEDENNAASILDQGERIN 1919
            .|.    |||....:|     .|....::.:       |:|:.:......::.|:|...||
Frog   841 TAP----TQALMNGDDGPSPLPQVPPPNQGNPGVGAFRDQEKQWGPTGGTQDGASSAPHQG---- 897

  Fly  1920 APADAMDGMFDPKNIKTEIDLEAHQMAEEPIGE------DDSQQVAEAMVQLSGVGGYYAQQQQD 1978
             |.:|::|       ..|:......:.|.|..|      .|..:.......:|.:....:....:
Frog   898 -PNNAVEG-------TAEVGQSKESLKEAPKSEPITAPRKDVARPQPGAETVSNLATLLSTASHN 954

  Fly  1979 ESMDVDPNYDPSDFLAMHKQRQSLGEPSSLQGAFTN---------FLSHEQDDNGPYN------- 2027
            ..:...|...||.|   ..||...|.|....|::..         :..|.|..:.||.
Frog   955 PGVVRPPGAYPSPF---PPQRYGNGHPQIAPGSYPRYPHQDPSYPYQRHPQQGHPPYQPYQQPPY 1016

  Fly  2028 -----------PAEASTSAASGAD---LGMDASMAMQMAP-----------EMPVNTMNNGMGID 2067
                       |.:..|....|..   .||....::.|:|           |..|.....|...:
Frog  1017 YPREYTRWPQPPQQRGTYPHPGPPQNLQGMGELRSLLMSPLLEGEPKAVPGEAKVQAEEEGQRSE 1081

  Fly  2068 DDLDISESDEE----DDGSR-----------------VRIKKEVFDDGDYALQHQQMGQAASQSQ 2111
            ...|..||.::    |...|                 .|....|.....|..||....|...|..
Frog  1082 GGSDRPESPKQFLDLDSHKRQCGSFGYEGPQPWGNGNFRPHPNVMPQPPYPPQHHYRPQGYPQPP 1146

  Fly  2112 IYMVDSSNEPTT------------LDYQQ--------------PPQLDFQQVQEMEQLQHQVMPP 2150
            ::.........|            ||:.:              ||   ||.:...:::..|:.||
Frog  1147 MHAPRHPGHAETNGHAALRPGYQNLDHNRGHFQAVMMEQSGNMPP---FQNMYRPQRMNFQMQPP 1208

  Fly  2151 MQSEQLQQQQTPQGD 2165
                 ...:.|.|||
Frog  1209 -----AFPKATGQGD 1218

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Taf1	NP_001246952.1	TBP-binding	15..76	CDD:286347
		DUF3591	652..1114	CDD:288969	10/25 (40%)
		zf-CCHC_6	1388..>1418	CDD:291934	6/36 (17%)
		Bromo_TFIID	1518..1629	CDD:99943	33/110 (30%)
		Bromo_TFIID	1640..1751	CDD:99943	21/161 (13%)
cecr2	XP_031754453.1	DDT	6..61	CDD:397084
		Bromo_gcn5_like	401..501	CDD:99941	34/150 (23%)
		PHA03247	<624..1071	CDD:223021	78/470 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D103411at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920