DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ass and ARG1

DIOPT Version :9

Sequence 1:	NP_001262324.1	Gene:	Ass / 40812	FlyBaseID:	FBgn0026565	Length:	419	Species:	Drosophila melanogaster
Sequence 2:	NP_014583.2	Gene:	ARG1 / 854096	SGDID:	S000005419	Length:	420	Species:	Saccharomyces cerevisiae

Alignment Length:	414	Identity:	203/414 - (49%)
Similarity:	273/414 - (65%)	Gaps:	16/414 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPKETVILAYSGGLDTSCVLKWLLDKQYEVICVLADVGQKEDFTAAEKKALKIGAKKVIVADVKQ 65
            |.|..|.||||||||||.:|.||||:.|||:..:|:|||:|||.||::|||||||.|.:..|.::
Yeast     1 MSKGKVCLAYSGGLDTSVILAWLLDQGYEVVAFMANVGQEEDFDAAKEKALKIGACKFVCVDCRE 65

  Fly    66 SFVEDYIWPAVQMGLVYEERYLLGTSLARPCISVALMEVAREYGAKYLAHGATGKGNDQVRFELC 130
            .||:|.::||||:..|||:.||||||||||.|:.|.::||::.|...::||.|||||||:||||.
Yeast    66 DFVKDILFPAVQVNAVYEDVYLLGTSLARPVIAKAQIDVAKQEGCFAVSHGCTGKGNDQIRFELS 130

  Fly   131 AYALKPDLKIIAPWRDVEFCCQFQGRQDLIAYAQQHGIEVSAKPATPWSTDANILHISYESGILE 195
            .||||||:|.|.|||..||..:|.||:||:.||.|.||.|:...|.|||||.|..|||||:||||
Yeast   131 FYALKPDVKCITPWRMPEFFERFAGRKDLLDYAAQKGIPVAQTKAKPWSTDENQAHISYEAGILE 195

  Fly   196 DPNTVAPENLYEMTVDPLTRAPRDPVHLVIQFDRGLP---SSVEDLPGGRV-YTKPLEMLDFLNK 256
            ||:|..|::::::.|||:. ||..|..|.|.|:||||   :..::.....| .||||::....:.
Yeast   196 DPDTTPPKDMWKLIVDPMD-APDQPQDLTIDFERGLPVKLTYTDNKTSKEVSVTKPLDVFLAASN 259

  Fly   257 LGGSYGIGRIDIVENRFVGLKSRGVYETPGGTILFAAHQDLEVFALDREVLRTKQVLRDRMA--D 319
            |..:.|:|||||||:|::.|||||.||....|:|..||.|||...||:||    :.|||...  :
Yeast   260 LARANGVGRIDIVEDRYINLKSRGCYEQAPLTVLRKAHVDLEGLTLDKEV----RQLRDSFVTPN 320

  Fly   320 Y---VYNGFWFSPEAIYARKCIELAEQRVSGKVTVELAPGYCRAIARKAAKDVGALYNEQLVSMD 381
            |   :|||.:|:||..|.|..|:.::..|:|.|.|.|..|....:.|....:  .||:....|||
Yeast   321 YSRLIYNGSYFTPECEYIRSMIQPSQNSVNGTVRVRLYKGNVIILGRSTKTE--KLYDPTESSMD 383

  Fly   382 VHGGYVPQDAGGFIAINAVRIREH 405
            ...|::|.|..|||||.|:||:::
Yeast   384 ELTGFLPTDTTGFIAIQAIRIKKY 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ass	NP_001262324.1	Argininosuccinate_Synthase	6..401	CDD:238957	199/403 (49%)
ARG1	NP_014583.2	Arginosuc_synth	7..406	CDD:279148	200/405 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343046
Domainoid	1	1.000	361	1.000	Domainoid score	I130
eggNOG	1	0.900	-	-		E1_COG0137
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6899
Inparanoid	1	1.050	366	1.000	Inparanoid score	I373
Isobase	1	0.950	-	0	Normalized mean entropy	S758
OMA	1	1.010	-	-		QHG60671
OrthoFinder	1	1.000	-	-		FOG0003927
OrthoInspector	1	1.000	-	-		oto99899
orthoMCL	1	0.900	-	-		OOG6_101359
Panther	1	1.100	-	-	LDO	PTHR11587
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R97
SonicParanoid	1	1.000	-	-		X2704
TreeFam	1	0.960	-	-
	16	15.740