DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2336 and Aldh1l2

DIOPT Version :9

Sequence 1:	NP_731094.3	Gene:	CG2336 / 40804	FlyBaseID:	FBgn0037455	Length:	322	Species:	Drosophila melanogaster
Sequence 2:	NP_705771.2	Gene:	Aldh1l2 / 216188	MGIID:	2444680	Length:	923	Species:	Mus musculus

Alignment Length:	345	Identity:	64/345 - (18%)
Similarity:	103/345 - (29%)	Gaps:	165/345 - (47%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 PTAISLEEEVQYIYKYP-------------------------------LLPTPLID---YG-FIY 36
            |.|::.|::...::|:|                               .:|..:||   :| .||
Mouse    63 PLALAAEKDGTPVFKFPRWRLKGKTIKEVAEAYQSVGAELNVLPFCTQFIPMDVIDSPKHGSIIY 127

  Fly    37 N-----------------LVCNKPRDVSV----------PLILEIETEFKSKDSA---------P 65
            :                 ::.:|....||          |::|:...:.|..|:.         |
Mouse   128 HPSLLPRHRGASAINWTLIMGDKKAGFSVFWADDGLDTGPILLQRSCDVKPNDTVDSLYNRFLFP 192

  Fly    66 EKPK------------KVPRLSYHSRSSSMSEDEPEPEVQVKYQ-----------WNSPRLMILC 107
            |..|            |.||             .|:||....|:           |:.|
Mouse   193 EGIKAMVEAVQLIADGKAPR-------------TPQPEEGATYEGIQKKENAEVSWDQP------ 238

  Fly   108 EDGDINCALHYLVESLHD--PFA---CNAVATLFLQESILEEFVDRIRDRLEPLSTDISGHPVYI 167
            .:|     ||..:.. ||  |.|   .|.....|...|:|...|.             ||.|:.|
Mouse   239 AEG-----LHNWIRG-HDKVPGAWAEINGQMVTFYGSSLLTSSVP-------------SGEPLDI 284

  Fly   168 MTLERIGHLQAKRIV--GNPKTVPENASPMLVYDL---------SHRYLADGPTGVITLHTFRTM 221
            ...::.|.:....:|  ||      :...::|.:|         :.:|.:.|.|.|:.|
Mouse   285 RGAKKPGLVTKNGLVLFGN------DGKALMVRNLQFEDGKMIPASQYFSAGETSVVEL------ 337

  Fly   222 KEAVELQAKEPLNFTSVCIW 241
             .|.||:..|    |...||
Mouse   338 -TAEELKVAE----TIKVIW 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2336	NP_731094.3	DUF1487	97..311	CDD:254173	36/172 (21%)
Aldh1l2	NP_705771.2	Fmt	22..326	CDD:223301	52/306 (17%)
		FMT_core_FDH_N	23..225	CDD:187716	28/174 (16%)
		GART	23..225		28/174 (16%)
		FDH_Hydrolase_C	228..327	CDD:187731	24/129 (19%)
		PP-binding	346..410	CDD:278949	4/11 (36%)
		ALDH_F1L_FTFDH	438..923	CDD:143458
		Aldehyde dehydrogenase	438..923
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900