DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2336 and ALDH16A1

DIOPT Version :9

Sequence 1:	NP_731094.3	Gene:	CG2336 / 40804	FlyBaseID:	FBgn0037455	Length:	322	Species:	Drosophila melanogaster
Sequence 2:	NP_699160.2	Gene:	ALDH16A1 / 126133	HGNCID:	28114	Length:	802	Species:	Homo sapiens

Alignment Length:	242	Identity:	52/242 - (21%)
Similarity:	93/242 - (38%)	Gaps:	64/242 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 LMILCEDGDINCALHYLVESLHDPFACNAVATLFLQESILEEFVDRIRDRLEPL--------STD 159
            |::|.:..|::.|:..:|::.........: .|.:|||:.:|.:.|:::|:..|        :.|
Human   278 LLLLTDTADVDSAVEGVVDAAWSDRGPGGL-RLLIQESVWDEAMRRLQERMGRLRSGRGLDGAVD 341

  Fly   160 ISGHPV----YIMTLERIGHLQAKRI--VGN--------PKTVPEN---ASPMLVYDLSHRYLAD 207
            :.....    .:....|....|..::  .|:        |.|:..|   |||....::
Human   342 MGARGAAACDLVQRFVREAQSQGAQVFQAGDVPSERPFYPPTLVSNLPPASPCAQVEV------- 399

  Fly   208 GPTGVITLHTFRTMKEAVELQAKEPLNFTSVCIWNEKLAAAYELVARLSPLIFTINCYYVNLNEI 272
             |..|:....|||.|||: |.|.......|..:|:|:|..|.||...|.     :...::|.:.:
Human   400 -PWPVVVASPFRTAKEAL-LVANGTPRGGSASVWSERLGQALELGYGLQ-----VGTVWINAHGL 457

  Fly   273 TLPFV---------CNFNSAKIIDG-YHYESLTFKGKRKVVVHPVGT 309
            ..|.|         |:::...  || |.|            :.|.||
Human   458 RDPSVPTGGCKESGCSWHGGP--DGLYEY------------LRPSGT 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2336	NP_731094.3	DUF1487	97..311	CDD:254173	52/242 (21%)
ALDH16A1	NP_699160.2	ALDH-SF	19..492	CDD:299846	52/242 (21%)
ALDH16A1	NP_699160.2	ALDH-SF	527..>765	CDD:299846
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900