DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2336 and ALDH1L1

DIOPT Version :9

Sequence 1:	NP_731094.3	Gene:	CG2336 / 40804	FlyBaseID:	FBgn0037455	Length:	322	Species:	Drosophila melanogaster
Sequence 2:	NP_001257293.1	Gene:	ALDH1L1 / 10840	HGNCID:	3978	Length:	912	Species:	Homo sapiens

Alignment Length:	270	Identity:	61/270 - (22%)
Similarity:	100/270 - (37%)	Gaps:	69/270 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 NRPTAISLEEEVQYI-----YKYPLL-----PTPLIDYGFIYNLVCNKPRDVSVPLILEIETEFK 59
            ||...::.:|.|...     :.|||:     ....:..|   |.|..||..|: ||......|..
Human   563 NRNLTLTRKEPVGVCGIIIPWNYPLMMLSWKTAACLAAG---NTVVIKPAQVT-PLTALKFAELT 623

  Fly    60 SKDSAPEKPKKV---------PRLSYH------------------SRSSSMSEDEPEPEVQVKYQ 97
            .|...|:....|         .|||.|                  .:|.::|..:   :|.::..
Human   624 LKAGIPKGVVNVLPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMKSCAISNVK---KVSLELG 685

  Fly    98 WNSPRLMILCEDGDINCALHYLVESL--HDPFACNAVATLFLQESILEEFVDRIRDRL------E 154
            ..||  :|:..|.|:|.|:...:.|:  :....|.|...||:::||.:|||.|:.:.:      .
Human   686 GKSP--LIIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSIHDEFVRRVVEEVRKMKVGN 748

  Fly   155 PLSTDIS-------GHPVYIMTLERIGHLQAKRIVGNPKTVPENA---SPMLVYDL-SHRYLAD- 207
            ||..|..       .|.|.:|...:.|..:...:|.....||...   .|.:..|: .|.::|.
Human   749 PLDRDTDHGPQNHHAHLVKLMEYCQHGVKEGATLVCGGNQVPRPGFFFEPTVFTDVEDHMFIAKE 813

  Fly   208 ---GPTGVIT 214
               ||..:|:
Human   814 ESFGPVMIIS 823

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2336	NP_731094.3	DUF1487	97..311	CDD:254173	35/141 (25%)
ALDH1L1	NP_001257293.1	Fmt	10..319	CDD:223301
		FMT_core_FDH_N	11..213	CDD:187716
		FDH_Hydrolase_C	216..316	CDD:187731
		PP-binding	335..401	CDD:278949
		ALDH_F1L_FTFDH	427..912	CDD:143458	61/270 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900