DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpr11 and IGSF9

DIOPT Version :9

Sequence 1:	NP_001262320.1	Gene:	dpr11 / 40800	FlyBaseID:	FBgn0053202	Length:	360	Species:	Drosophila melanogaster
Sequence 2:	NP_001128522.1	Gene:	IGSF9 / 57549	HGNCID:	18132	Length:	1179	Species:	Homo sapiens

Alignment Length:	263	Identity:	76/263 - (28%)
Similarity:	94/263 - (35%)	Gaps:	46/263 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 GAGTSEGAGTSSASAASTAISSDESGDPSSATAFSSLAQVSSLLPEASALSATSGLV-EPYLDGY 122
            |....:|.|.......:..|...|.|.....|     .|.||  .|.||..||..|| .|.:...
Human   174 GKDLGQGQGQVQVQNGTLRIRRVERGSSGVYT-----CQASS--TEGSATHATQLLVLGPPVIVV 231

  Fly   123 ATSNVTTQIGTHAYLPCRVKQL-GNKSVSWIR--LRDGHILTVDRAVFI---ADQRFLAIKQPDK 181
            ...|.|........|.|..:.. .|.:.||.:  :...||..:...|.|   ...|.|| .|||
Human   232 PPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLA-TQPD- 294

  Fly   182 YWTLQIKYVQARDAGSYECQVST---EPKVSARVQLQVVVPRTEILGEPDRYVKAGSNVVLRCIV 243
                        |||.|.|..|.   .|. ||...|.|:.|.......|:..:..|...|:||.|
Human   295 ------------DAGCYTCVPSNGLLHPP-SASAYLTVLYPAQVTAMPPETPLPIGMPGVIRCPV 346

  Fly   244 RGALEPPTFIMWYHGAEQLAADSRRHRTQLDPNLPEASGEGQSTIGSLIIESAKKRDTGNYTCSP 308
            | |..|..|:.|....:.|         |||    :..|..|.|.|||||....:...|.|:|:|
Human   347 R-ANPPLLFVSWTKDGKAL---------QLD----KFPGWSQGTEGSLIIALGNEDALGEYSCTP 397

  Fly   309 SNS 311
            .||
Human   398 YNS 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr11	NP_001262320.1	I-set	125..216	CDD:254352	27/99 (27%)
		Ig	127..217	CDD:299845	26/98 (27%)
		IG_like	227..320	CDD:214653	29/85 (34%)
		IGc2	234..311	CDD:197706	26/76 (34%)
IGSF9	NP_001128522.1	Ig	24..132	CDD:299845
		IG_like	28..110	CDD:214653
		I-set	136..223	CDD:254352	15/55 (27%)
		Ig	154..220	CDD:143165	14/52 (27%)
		Ig_3	226..305	CDD:290638	23/92 (25%)
		IG_like	233..319	CDD:214653	27/100 (27%)
		Ig	341..404	CDD:299845	27/74 (36%)
		IG_like	431..503	CDD:214653
		Ig	436..500	CDD:143165
		fn3	511..596	CDD:278470
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	606..626
		FN3	625..715	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	767..919
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	940..988
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1015..1079
		PDZ-binding. /evidence=ECO:0000250	1177..1179
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810