DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpr11 and LRIT3

DIOPT Version :9

Sequence 1:	NP_001262320.1	Gene:	dpr11 / 40800	FlyBaseID:	FBgn0053202	Length:	360	Species:	Drosophila melanogaster
Sequence 2:	NP_940908.3	Gene:	LRIT3 / 345193	HGNCID:	24783	Length:	679	Species:	Homo sapiens

Alignment Length:	363	Identity:	82/363 - (22%)
Similarity:	126/363 - (34%)	Gaps:	145/363 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 SSDESGDPSSATAFSSLAQVSSLLPEASALSA---TSGLVEP----------------------- 117
            :|..|.||||   |.:|.|:..|..:.::|:|   .|.|..|
Human    91 NSVASIDPSS---FYNLKQLHELRLDGNSLAAFPWASLLDMPLLRTLDLHNNKITSVPNEALRYL 152

  Fly   118 ----YLDGYATSN----------------VTTQIGTHAYLPCRVKQLGNKSVSWIRLRDGHI--- 159
                |||  .:||                |:|..|.....|.|: .||.:...|  ..|.||
Human   153 KNLAYLD--LSSNRLTTLPPDFLESWTHLVSTPSGVLDLSPSRI-ILGLQDNPW--FCDCHISKM 212

  Fly   160 ----LTVDRAVFIADQRFLAIKQPDKYWTLQIKYVQARDAGSYECQVSTEPKVSARVQLQVVVPR 220
                ..||.|:.:.|. .:...:|::  ...|.:.:|      |.:...:|        .|:...
Human   213 IELSKVVDPAIVLLDP-LMTCSEPER--LTGILFQRA------ELEHCLKP--------SVMTSA 260

  Fly   221 TEILGEPDRYVKAGSNVVLRCIVRGALEPPTFIMWYHGAEQLAADSRRHRTQLDPN------LPE 279
            |:|:.      ..||||:|||...|.  |...|.|               |:.|.:      :.|
Human   261 TKIMS------ALGSNVLLRCDATGF--PTPQITW---------------TRSDSSPVNYTVIQE 302

  Fly   280 ASGEG-QSTIGSLIIESAKKRDTGNYTCSPSN---SPSATVTLNII--------------NGE-- 324
            :..|| :.:|.||...|:|  |.|:|.|...|   ...|.||:.::              .|:
Human   303 SPEEGVRWSIMSLTGISSK--DAGDYKCKAKNLAGMSEAVVTVTVLGITTTPIPPDTSERTGDHP 365

  Fly   325 --------------SSASAV--TSSAATTRAYALSILA 346
                          ||||:.  :||.:.|.:::.|.|:
Human   366 EWDVQPGSGRSTSVSSASSYLWSSSFSPTSSFSASTLS 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr11	NP_001262320.1	I-set	125..216	CDD:254352	22/113 (19%)
		Ig	127..217	CDD:299845	20/96 (21%)
		IG_like	227..320	CDD:214653	29/102 (28%)
		IGc2	234..311	CDD:197706	26/86 (30%)
LRIT3	NP_940908.3	LRR 1	56..79
		leucine-rich repeat	59..82	CDD:275378
		LRR_8	61..117	CDD:290566	10/28 (36%)
		LRR 2	80..103		7/14 (50%)
		leucine-rich repeat	83..106	CDD:275378	8/17 (47%)
		LRR 3	104..128		7/23 (30%)
		LRR_8	105..165	CDD:290566	12/61 (20%)
		LRR_4	105..146	CDD:289563	7/40 (18%)
		leucine-rich repeat	107..130	CDD:275378	5/22 (23%)
		LRR 4	129..151		1/21 (5%)
		LRR_4	131..170	CDD:289563	5/40 (13%)
		leucine-rich repeat	131..154	CDD:275378	0/22 (0%)
		LRR 5	152..175		5/24 (21%)
		leucine-rich repeat	155..168	CDD:275378	5/14 (36%)
		Ig	267..345	CDD:299845	29/96 (30%)
		IG_like	267..345	CDD:214653	29/96 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	351..375		1/23 (4%)
		FN3	486..550	CDD:214495
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900