DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr11 and Sdk1

DIOPT Version :9

Sequence 1:	NP_001262320.1	Gene:	dpr11 / 40800	FlyBaseID:	FBgn0053202	Length:	360	Species:	Drosophila melanogaster
Sequence 2:	NP_808547.3	Gene:	Sdk1 / 330222	MGIID:	2444413	Length:	2193	Species:	Mus musculus

Alignment Length:	270	Identity:	73/270 - (27%)
Similarity:	110/270 - (40%)	Gaps:	49/270 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 VSSLLPEASAL-----SATSGLVE--PYLD------GYATSNVTTQI--GTHAYLPCRVKQLGNK 147
            :..|.||.|.:     |...|.|:  .|||      .:....|.|.:  |..|.|.|.|......
Mouse   427 IQKLSPEDSGIFQCFASNEGGEVQTHTYLDVTNIAPAFTQRPVDTTVTDGMTAVLRCEVSGAPKP 491

  Fly   148 SVSWIRLRDGHILTVDRAVFIADQRFLAIKQPDKYWTLQIKYVQARDAGSYEC-QVSTEPKVSAR 211
            :::|  .|..|||.   :..:...||:.::...    |:|..|..:|||:|.| ..:||..|:|.
Mouse   492 AITW--KRGNHILA---SGSVRIPRFMLLESGG----LRIAPVFIQDAGNYTCYAANTEASVNAS 547

  Fly   212 VQLQVVVPRTEILGEP-DRYVKAGSNVVLRCIVRGALEPPTFIMWYHGAEQLAADSRRHRTQLDP 275
            ..| .|..||.|:..| ||.|..|:...|.|   ||...|             ..|.|:..:.|.
Mouse   548 AML-TVWNRTSIVHPPEDRVVIKGTTATLCC---GATHDP-------------RTSLRYVWKKDN 595

  Fly   276 NLPEASGEGQSTI---GSLIIESAKKRDTGNYTC---SPSNSPSATVTLNIINGESSASAVTSSA 334
            .:..||...:..:   |||:|......|.|:|||   |...|.|.|..|.:|........:.:|.
Mouse   596 VVITASSSSRIVVEKDGSLVISQTWSGDIGDYTCEIISEGGSDSRTARLEVIELPHPPQNLLASL 660

  Fly   335 ATTRAYALSI 344
            :..|::::::
Mouse   661 SPARSHSVTL 670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr11	NP_001262320.1	I-set	125..216	CDD:254352	27/93 (29%)
		Ig	127..217	CDD:299845	27/92 (29%)
		IG_like	227..320	CDD:214653	29/99 (29%)
		IGc2	234..311	CDD:197706	21/82 (26%)
Sdk1	NP_808547.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..56
		Ig_2	94..169	CDD:290606
		IG_like	100..169	CDD:214653
		IG_like	183..263	CDD:214653
		Ig	197..247	CDD:299845
		IG_like	281..357	CDD:214653
		IGc2	294..347	CDD:197706
		I-set	368..457	CDD:254352	9/29 (31%)
		Ig	388..454	CDD:143165	7/26 (27%)
		I-set	462..552	CDD:254352	27/99 (27%)
		Ig	476..552	CDD:299845	25/85 (29%)
		I-set	557..646	CDD:254352	30/104 (29%)
		Ig	562..646	CDD:299845	29/99 (29%)
		FN3	650..741	CDD:238020	2/21 (10%)
		fn3	753..839	CDD:278470
		FN3	854..949	CDD:238020
		FN3	954..1036	CDD:238020
		FN3	1052..1148	CDD:238020
		FN3	1158..1253	CDD:238020
		FN3	1261..1349	CDD:238020
		FN3	1360..1453	CDD:238020
		FN3	1459..1554	CDD:238020
		FN3	1562..1676	CDD:238020
		FN3	1686..1779	CDD:238020
		FN3	1784..1865	CDD:238020
		FN3	1885..1978	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2057..2080
		PDZ-binding. /evidence=ECO:0000250\|UniProtKB:Q6V4S5	2187..2193
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810