DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr11 and Ncam2

DIOPT Version :9

Sequence 1:	NP_001262320.1	Gene:	dpr11 / 40800	FlyBaseID:	FBgn0053202	Length:	360	Species:	Drosophila melanogaster
Sequence 2:	NP_981954.2	Gene:	Ncam2 / 288280	RGDID:	1303131	Length:	837	Species:	Rattus norvegicus

Alignment Length:	192	Identity:	43/192 - (22%)
Similarity:	74/192 - (38%)	Gaps:	48/192 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 GTHAYLPCRVKQLGNKSVSWIRLRDGHILTVDRAVFIADQRFLAIKQPDKYWTLQIKYVQARDAG 196
            |..|.:.|||......:|||: ..:..:.|      |.|.||..:...:    |||..:...|.|
  Rat   129 GEDAEVVCRVSSSPAPAVSWL-YHNEEVTT------IPDNRFAVLANNN----LQILNINKSDEG 182

  Fly   197 SYECQVSTEPKVSARVQLQ-------------VVVPRTEILGEPDRYVKAGSNVVLRCIVRGALE 248
            .|.|    |.:|.||.::.             :|:|:.......:|    |..:.|.|...|:.:
  Rat   183 IYRC----EGRVEARGEIDFRDIIVIVNVPPAIVMPQKSFNATAER----GEEMTLTCKASGSPD 239

  Fly   249 PPTFIMWYHGAEQLAADSRRHRTQLDPNLPEASGEGQSTIGSLIIESAKKRDTGNYTCSPSN 310
            |.  |.|:... :|..::.::..           :|.:|  .|.:.:...:|.|:|.|..:|
  Rat   240 PA--ISWFRNG-KLIEENEKYIL-----------KGSNT--ELTVRNIINKDGGSYVCKATN 285

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr11	NP_001262320.1	I-set	125..216	CDD:254352	24/96 (25%)
		Ig	127..217	CDD:299845	24/97 (25%)
		IG_like	227..320	CDD:214653	17/84 (20%)
		IGc2	234..311	CDD:197706	16/77 (21%)
Ncam2	NP_981954.2	IgI_1_NCAM-2	21..113	CDD:409452
		Ig strand B	38..42	CDD:409452
		Ig strand C	50..54	CDD:409452
		Ig strand E	76..80	CDD:409452
		Ig strand F	90..95	CDD:409452
		Ig strand G	104..107	CDD:409452
		IGc2	128..189	CDD:197706	21/74 (28%)
		Ig strand B	130..139	CDD:409353	3/8 (38%)
		Ig strand C	145..153	CDD:409353	3/8 (38%)
		Ig strand C'	156..159	CDD:409353	1/8 (13%)
		Ig strand D	162..167	CDD:409353	2/4 (50%)
		Ig strand E	168..175	CDD:409353	3/10 (30%)
		IgI_1_MuSK	209..298	CDD:409562	19/97 (20%)
		Ig strand B	228..232	CDD:409562	1/3 (33%)
		Ig strand C	241..245	CDD:409562	1/5 (20%)
		Ig strand E	264..268	CDD:409562	2/5 (40%)
		Ig strand F	278..283	CDD:409562	2/4 (50%)
		Ig strand G	291..294	CDD:409562
		Ig	300..397	CDD:416386
		Ig strand A	300..305	CDD:409353
		Ig strand A'	309..313	CDD:409353
		Ig strand B	317..325	CDD:409353
		Ig strand C	331..337	CDD:409353
		Ig strand C'	340..343	CDD:409353
		Ig strand D	353..359	CDD:409353
		Ig strand E	362..368	CDD:409353
		Ig strand F	376..384	CDD:409353
		Ig strand G	387..397	CDD:409353
		Ig_3	401..479	CDD:404760
		Ig strand B	418..422	CDD:409353
		Ig strand C	431..435	CDD:409353
		Ig strand E	458..462	CDD:409353
		Ig strand F	472..477	CDD:409353
		Ig strand G	486..489	CDD:409353
		FN3	496..588	CDD:238020
		fn3	594..678	CDD:394996
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900