DRSC/TRiP Functional Genomics Resources

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Protein Alignment dpr11 and SDK1

DIOPT Version :9

Sequence 1:NP_001262320.1 Gene:dpr11 / 40800 FlyBaseID:FBgn0053202 Length:360 Species:Drosophila melanogaster
Sequence 2:NP_689957.3 Gene:SDK1 / 221935 HGNCID:19307 Length:2213 Species:Homo sapiens


Alignment Length:412 Identity:97/412 - (23%)
Similarity:145/412 - (35%) Gaps:101/412 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 NRS---RSEMQTLE--TRVRPLQ---------GAQLTQLLLGGILCLTIASHTQTSAEAAGGRVS 56
            |||   .|...|||  ...||::         |.::|..|......|||::.|...........:
Human   301 NRSVVAGSSETTLECIASARPVEDLSVTWKRNGVRITSGLHSFGRRLTISNPTSADTGPYVCEAA 365

  Fly    57 GPGAG------------------TSEGAGTSSASAAST--------------------AISSDES 83
            .||:.                  |:|.....||....|                    |||....
Human   366 LPGSAFEPARATAFLFIIEPPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISISRL 430

  Fly    84 GDPSSATAFSSLAQVSSLLPEASAL-----SATSGLVE--PYLDGYATSNVTTQ--------IGT 133
            .:|......|...::..|.||.|.:     |...|.::  .|||....:.|.||        .|.
Human   431 QNPRYKVLASGGLRIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVDTTVTDGM 495

  Fly   134 HAYLPCRVKQLGNKSVSWIRLRDGHILTVDRAVFIADQRFLAIKQPDKYWTLQIKYVQARDAGSY 198
            .|.|.|.|......:::|  .|:.|||.   :..:...||:.::...    |||..|..:|||:|
Human   496 TAILRCEVSGAPKPAITW--KRENHILA---SGSVRIPRFMLLESGG----LQIAPVFIQDAGNY 551

  Fly   199 EC-QVSTEPKVSARVQLQVVVPRTEILGEP-DRYVKAGSNVVLRCIVRGALEPPTFIMWYHGAEQ 261
            .| ..:||..::|...| .|..||.|:..| |..|..|:...|.|   ||...|...:.|..   
Human   552 TCYAANTEGSLNASATL-TVWNRTSIVHPPEDHVVIKGTTATLHC---GATHDPRVSLRYVW--- 609

  Fly   262 LAADSRRHRTQLDPNLPEASGEGQSTI---GSLIIESAKKRDTGNYTC---SPSNSPSATVTLNI 320
                 ::....|.|     |...:..:   |||:|......|.|:|:|   |...:.|....|.:
Human   610 -----KKDNVALTP-----SSTSRIVVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMARLEV 664

  Fly   321 INGESSASAVTSSAATTRAYAL 342
            |....|...:..|..::.::|:
Human   665 IELPHSPQNLLVSPNSSHSHAV 686

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpr11NP_001262320.1 I-set 125..216 CDD:254352 28/99 (28%)
Ig 127..217 CDD:299845 28/98 (29%)
IG_like 227..320 CDD:214653 24/99 (24%)
IGc2 234..311 CDD:197706 19/82 (23%)
SDK1NP_689957.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..73
I-set 104..188 CDD:254352
Ig 122..176 CDD:143165
Ig 219..265 CDD:299845
IGc2 312..364 CDD:197706 12/51 (24%)
I-set 386..475 CDD:254352 18/88 (20%)
Ig 404..472 CDD:143165 11/67 (16%)
I-set 480..570 CDD:254352 28/99 (28%)
Ig 494..570 CDD:299845 25/85 (29%)
I-set 575..664 CDD:254352 25/104 (24%)
Ig 580..664 CDD:299845 24/99 (24%)
FN3 668..759 CDD:238020 3/19 (16%)
fn3 771..857 CDD:278470
FN3 872..967 CDD:238020
FN3 972..1054 CDD:238020
FN3 1070..1166 CDD:238020
FN3 1176..1271 CDD:238020
fn3 1279..1365 CDD:278470
FN3 1378..1471 CDD:238020
FN3 1477..1572 CDD:238020
FN3 1580..1694 CDD:238020
FN3 1704..1797 CDD:238020
FN3 1802..1883 CDD:238020
FN3 1903..1996 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2075..2098
PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q6V4S5 2207..2213
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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