DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr11 and DSCAM

DIOPT Version :9

Sequence 1:	NP_001262320.1	Gene:	dpr11 / 40800	FlyBaseID:	FBgn0053202	Length:	360	Species:	Drosophila melanogaster
Sequence 2:	NP_001380.2	Gene:	DSCAM / 1826	HGNCID:	3039	Length:	2012	Species:	Homo sapiens

Alignment Length:	247	Identity:	60/247 - (24%)
Similarity:	105/247 - (42%)	Gaps:	29/247 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 PSSATAFSSLAQVSSLLPEASALSATSGLVEPYLDGYATSNVTTQIGTHAYLPCRVKQLGNKSVS 150
            ||.:.::  :.:||:....|..:.... :.:|.....:...|.:.:|:...|.|.|....::.:|
Human   285 PSDSGSY--VCEVSNRYGTAKVIGRLY-VKQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQELS 346

  Fly   151 WIRLRDGHILTVDRAVFIADQRFLAIKQPDKYWTLQIKYVQARDAGSYECQVSTEPKVSARVQLQ 215
            |  .|:|.||...:.|     |...|...:    |.:.::...|.|:|:|.|..: |:||:..:|
Human   347 W--YRNGEILNPGKNV-----RITGINHEN----LIMDHMVKSDGGAYQCFVRKD-KLSAQDYVQ 399

  Fly   216 VVV----PRTEILGEPDRYVKAGSNVVLRCIVRGALEPPTFIMWYHGAEQLAADSRRHRTQLDPN 276
            ||:    |:. |....::.|.....|.|.|.|:|.  |...|.|....:.:........:|:
Human   400 VVLEDGTPKI-ISAFSEKVVSPAEPVSLMCNVKGT--PLPTITWTLDDDPILKGGSHRISQM--- 458

  Fly   277 LPEASGEGQSTIGSLIIESAKKRDTGNYTCSPSNSPSATVTLNIINGESSAS 328
               .:.|| :.:..|.|.|::.||.|.|.|:.:||....:....||....||
Human   459 ---ITSEG-NVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPAS 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr11	NP_001262320.1	I-set	125..216	CDD:254352	23/90 (26%)
		Ig	127..217	CDD:299845	24/89 (27%)
		IG_like	227..320	CDD:214653	22/92 (24%)
		IGc2	234..311	CDD:197706	19/76 (25%)
DSCAM	NP_001380.2	Ig	45..113	CDD:319273
		I-set	235..310	CDD:254352	5/27 (19%)
		I-set	315..385	CDD:333254	18/80 (23%)
		Ig_3	407..488	CDD:316449	22/90 (24%)
		IGc2	518..575	CDD:197706
		I-set	596..686	CDD:333254
		Ig_DSCAM	707..784	CDD:143211
		Ig	802..889	CDD:325142
		FN3	885..978	CDD:238020
		FN3	986..1083	CDD:238020
		FN3	1091..1184	CDD:238020
		FN3	1189..1278	CDD:238020
		Ig	1303..1369	CDD:319273
		FN3	1380..1470	CDD:238020
		FN3	1486..1555	CDD:238020
		Required for netrin-mediated axon repulsion of neuronal growth cones. /evidence=ECO:0000250\|UniProtKB:Q9ERC8	1617..2012
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1718..1810
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1855..1883
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1971..2012
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810