DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr11 and rig-4

DIOPT Version :9

Sequence 1:	NP_001262320.1	Gene:	dpr11 / 40800	FlyBaseID:	FBgn0053202	Length:	360	Species:	Drosophila melanogaster
Sequence 2:	NP_501339.2	Gene:	rig-4 / 177597	WormBaseID:	WBGene00004371	Length:	2325	Species:	Caenorhabditis elegans

Alignment Length:	321	Identity:	67/321 - (20%)
Similarity:	126/321 - (39%)	Gaps:	85/321 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 GGRVSGPGAGTSEGAGTSSASAASTAISSDESGDPSSATAFSSLAQVSSLLPEASALSATSGLVE 116
            |.::||     ||...|::.:.....||     :|||.|......:..:    .:|:..||....
Worm   265 GQQISG-----SEVGMTTTLNNRRLIIS-----NPSSFTRGEHKLECRA----DAAMGRTSDQKS 315

  Fly   117 PYLDGYA-------TSNVTTQIGTHAYLPCRVKQLGNKSVSWIRLRDGHILTVDRAVFIADQRFL 174
            .|:...:       .:.:...:|:...|.|.||:..:..:.|  .::|.::|..|.....|:
Worm   316 AYMTFISRPILKDLPNEIQKTVGSSLSLKCSVKKKSSMDIKW--YKNGLMMTTQRGKLTIDR--- 375

  Fly   175 AIKQPD-----------------KYWTLQ------IKYVQARDAGSYECQVSTE---PKV----- 208
             |||.|                 ..|..:      :....:.|..|.|.::|.|   |:.
Worm   376 -IKQDDFGLYQCEATNAAGADLASVWVKEGEANETVATEMSEDGMSLEEEISMETPPPRKLKFFD 439

  Fly   209 SARVQLQV------VVPRTEILGEP-DRYVKAGSN-VVLRCIVRGALEPPTFIMWYHGAEQLAAD 265
            :::.|.|:      :.|..:::..| |..|.:|:: :::.|...|:  ||..|:|.....::..|
Worm   440 NSKSQEQLFPFTSELEPSQKLIKTPKDLTVASGTDRIMMECAATGS--PPPNIIWLLNGHEIQTD 502

  Fly   266 SRRHRTQLDPNLPEASGEGQSTIGSLIIESAKKRDTGNYTCSPSNSPSATVTLNI-INGES 325
            :.::         :.:.:|      |.|...:|.|.|.|||..|.| :...|.|: :||:|
Worm   503 NVKY---------DLTNDG------LAIHDIRKSDEGEYTCEISGS-NVKATANVQVNGDS 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr11	NP_001262320.1	I-set	125..216	CDD:254352	22/121 (18%)
		Ig	127..217	CDD:299845	23/126 (18%)
		IG_like	227..320	CDD:214653	23/94 (24%)
		IGc2	234..311	CDD:197706	18/77 (23%)
rig-4	NP_501339.2	IG_like	330..402	CDD:214653	15/77 (19%)
		IGc2	338..393	CDD:197706	14/60 (23%)
		I-set	459..543	CDD:254352	24/101 (24%)
		IGc2	478..534	CDD:197706	18/73 (25%)
		IG_like	553..639	CDD:214653
		Ig	564..635	CDD:143165
		FN3	643..747	CDD:238020
		FN3	756..850	CDD:238020
		FN3	858..954	CDD:238020
		FN3	959..1042	CDD:238020
		FN3	1057..1151	CDD:238020
		FN3	1156..1251	CDD:238020
		FN3	1258..1356	CDD:238020
		FN3	1361..1453	CDD:238020
		FN3	1464..1560	CDD:238020
		FN3	1572..1664	CDD:238020
		FN3	1679..1764	CDD:238020
		FN3	1774..1858	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810