DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr11 and Dscam

DIOPT Version :9

Sequence 1:	NP_001262320.1	Gene:	dpr11 / 40800	FlyBaseID:	FBgn0053202	Length:	360	Species:	Drosophila melanogaster
Sequence 2:	XP_006522949.1	Gene:	Dscam / 13508	MGIID:	1196281	Length:	2034	Species:	Mus musculus

Alignment Length:	251	Identity:	60/251 - (23%)
Similarity:	107/251 - (42%)	Gaps:	29/251 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 ESGDPSSATAFSSLAQVSSLLPEASALSATSGLVEPYLDGYATSNVTTQIGTHAYLPCRVKQLGN 146
            |:..||.:.::  :.:||:....|..:.... :.:|.....:...|.:.:|:...|.|.|....:
Mouse   281 ENSRPSDSGSY--VCEVSNRYGTAKVIGRLY-VKQPLKATISPRKVKSSVGSQVSLSCSVTGNED 342

  Fly   147 KSVSWIRLRDGHILTVDRAVFIADQRFLAIKQPDKYWTLQIKYVQARDAGSYECQVSTEPKVSAR 211
            :.:||  .|:|.||...:.|.|...         .:..|.:.::...|.|:|:|.|..: |:||:
Mouse   343 QELSW--YRNGEILNPGKNVRITGL---------NHANLIMDHMVKSDGGAYQCFVRKD-KLSAQ 395

  Fly   212 VQLQVVV----PRTEILGEPDRYVKAGSNVVLRCIVRGALEPPTFIMWYHGAEQLAADSRRHRTQ 272
            ..:|||:    |:. |....::.|.....|.|.|.|:|.  |...:.|....:.:...|....:|
Mouse   396 DYVQVVLEDGTPKI-ISAFSEKVVSPAEPVSLVCNVKGT--PLPTVTWTLDDDPILKGSGHRISQ 457

  Fly   273 LDPNLPEASGEGQSTIGSLIIESAKKRDTGNYTCSPSNSPSATVTLNIINGESSAS 328
            :      .:.|| :.:..|.|.|::.||.|.|.|:.:||....:....||....||
Mouse   458 M------ITSEG-NVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPAS 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr11	NP_001262320.1	I-set	125..216	CDD:254352	22/90 (24%)
		Ig	127..217	CDD:299845	23/89 (26%)
		IG_like	227..320	CDD:214653	22/92 (24%)
		IGc2	234..311	CDD:197706	19/76 (25%)
Dscam	XP_006522949.1	Ig	15..115	CDD:386229
		IGc2	239..300	CDD:197706	5/20 (25%)
		IG	320..400	CDD:214652	22/91 (24%)
		Ig_3	410..488	CDD:372822	21/86 (24%)
		IGc2	518..575	CDD:197706
		Ig	596..686	CDD:386229
		Ig_DSCAM	707..784	CDD:143211
		Ig	802..889	CDD:386229
		FN3	885..978	CDD:238020
		FN3	986..1083	CDD:238020
		FN3	1091..1184	CDD:238020
		FN3	1189..1278	CDD:238020
		Ig_3	1301..1363	CDD:372822
		FN3	1380..1470	CDD:238020
		FN3	1486..1555	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900