Protein Alignment ARRB1 and Arr2

DIOPT Version :10

• Sequence 1: XP_016873239.1
• Gene: ARRB1 / 408
• HGNCID: 711
• Length: 473
• Species: Homo sapiens
• Sequence 2: NP_523976.1
• Gene: Arr2 / 38993
• FlyBaseID: FBgn0000121
• Length: 401
• Species: Drosophila melanogaster
• Alignment Length: 426
• Identity: 176/426 - (41%)
• Similarity: 256/426 - (60%)
• Gaps: 43/426 - (10%)

Human    38 RVFKKASPNGKLTVYLGKRDFVDHIDLVDPVDGVVLVDPEYLKERRVYVTLTCAFRYGREDLDVL 102
            :|||||:||||:|.|||:|||:||||..||||||::|:|:|||.|:|:..|...:|||||:.:|:
  Fly     6 KVFKKATPNGKVTFYLGRRDFIDHIDYCDPVDGVIVVEPDYLKNRKVFGQLATTYRYGREEDEVM 70

Human   103 GLTFRKDLFVANVQSFPPAPEDKKPLTRLQERLIKKLGEHAYPFTFEIPPNLPCSVTLQPGPEDT 167
            |:.|.|:|.:...| ..|.......:|.:||:|::|||.:||||||..|||.|.|||||...:|.
  Fly    71 GVKFSKELILCREQ-IVPMTNPNMEMTPMQEKLVRKLGSNAYPFTFHFPPNSPSSVTLQQEGDDN 134

Human   168 GKACGVDYEVKAFCAENLEEKIHKRNSVRLVIRKVQYAPERPGPQ-PTAETTRQFLMSDKPLHLE 231
            ||..||:|.::||..::.:::.|||:.|.|||:|:||||...|.: |::..::.|..|:..:.||
  Fly   135 GKPLGVEYTIRAFVGDSEDDRQHKRSMVSLVIKKLQYAPLNRGQRLPSSLVSKGFTFSNGKISLE 199

Human   232 ASLDKEIYYHGEPISVNVHVTNNTNKTVKKIKISVRQYADICLFNTAQYKCPVAMEEADD--TVA 294
            .:||:|||||||..:..|.|:||:.|:||.||..:.|:.:|.:.| ||:...||..|..:  .:.
  Fly   200 VTLDREIYYHGEKTAATVQVSNNSKKSVKSIKCFIVQHTEITMVN-AQFSKHVAQLETKEGCPIT 263

Human   295 PSSTFCKVYTLTPFLANNREKRGLALDGKLKHEDTNLASSTLLREG-ANREILGIIVSYKVKVKL 358
            |.:...|.:.|.|..|||:::.|:||||.||.||.||||||:::|| :..:..||::||.|::||
  Fly   264 PGANLTKTFYLIPLAANNKDRHGIALDGHLKDEDVNLASSTMVQEGKSTGDACGIVISYSVRIKL 328

Human   359 VVSRGGLLGDLASSDVAVELPFTLMHPKP-----KEEPPHREVPENETPVDTNLIELDTNQRPSS 418
               ..|.||....:||    ||.|:.|.|     |.....:::...|                 .
  Fly   329 ---NCGTLGGEMQTDV----PFKLLQPAPGTIEKKRSNAMKKMKSIE-----------------Q 369

Human   419 HRTVARGGGPGPTARTASSDDDIVFEDFARQRLKGM 454
            ||.|        .......||:|||||||:.|:..:
  Fly   370 HRNV--------KGYYQDDDDNIVFEDFAKMRMNNV 397

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ARRB1	XP_016873239.1	Arrestin_N	49..205	CDD:425619	76/155 (49%)
		Arrestin_C	224..387	CDD:214976	69/165 (42%)
Arr2	NP_523976.1	Arrestin_N	17..172	CDD:425619	76/155 (49%)
		Arrestin_C	192..350	CDD:214976	69/165 (42%)