DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ARRB1 and Arr1

DIOPT Version :9

Sequence 1:	XP_016873239.1	Gene:	ARRB1 / 408	HGNCID:	711	Length:	473	Species:	Homo sapiens
Sequence 2:	NP_001246073.1	Gene:	Arr1 / 35078	FlyBaseID:	FBgn0000120	Length:	364	Species:	Drosophila melanogaster

Alignment Length:	356	Identity:	164/356 - (46%)
Similarity:	238/356 - (66%)	Gaps:	11/356 - (3%)

- Green bases have known domain annotations that are detailed below.

Human    38 RVFKKASPNGKLTVYLGKRDFVDHIDLVDPVDGVVLVDPEYLKE-RRVYVTLTCAFRYGREDLDV 101
            :||||.|||..:|:|:.:|||||.:..|:|:||::::|.||::: |:::|.|.|.|||||||.::
  Fly     6 KVFKKCSPNNMITLYMNRRDFVDSVTQVEPIDGIIVLDDEYVRQNRKIFVQLVCNFRYGREDDEM 70

Human   102 LGLTFRKDLFVANVQSFPPAPEDKKPLTRLQERLIKKLGEHAYPFTFEIPPNLPCSVTLQPGPED 166
            :||.|:|:|.:.:.|..||..:|.: ||::||||:||||.:||||..::||:.|.||.||....|
  Fly    71 IGLRFQKELTLVSQQVCPPQKQDIQ-LTKMQERLLKKLGSNAYPFVMQMPPSSPASVVLQQKASD 134

Human   167 TGKACGVDYEVKAFCAENLEEKIHKRNSVRLVIRKVQYAPERPGPQPTAETTRQFLMSDKPLHLE 231
            ..:.|||.|.||.|..::..::.|:|:::.|.||||||||.:.|.||.....:.||:|...|.||
  Fly   135 ESQPCGVQYFVKIFTGDSDCDRSHRRSTINLGIRKVQYAPTKQGIQPCTVVRKDFLLSPGELELE 199

Human   232 ASLDKEIYYHGEPISVNVHVTNNTNKTVKKIKISVRQYADICLFNTAQYKCPVAMEEADD--TVA 294
            .:|||::|:|||.||||:.|.||:||.|||||..|:|..|:.||...|::..:|..|..:  .:.
  Fly   200 VTLDKQLYHHGEKISVNICVRNNSNKVVKKIKAMVQQGVDVVLFQNGQFRNTIAFMETSEGCPLN 264

Human   295 PSSTFCKVYTLTPFLANNREKRGLALDGKLKHEDTNLASSTLLREGANREILGIIVSYKVKVKLV 359
            |.|:..||..|.|.|..|.::.|:|::|.:|.:||.|||:||:.....|:..||||||.|||||.
  Fly   265 PGSSLQKVMYLVPTLVANCDRAGIAVEGDIKRKDTALASTTLIASQDARDAFGIIVSYAVKVKLF 329

Human   360 VSRGGLLGDLASSDVAVELPFTLMHPKPKEE 390
            :  |.|.|:|.:     ||||.||||||..:
  Fly   330 L--GALGGELCA-----ELPFILMHPKPSRK 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ARRB1	XP_016873239.1	None
Arr1	NP_001246073.1	Arrestin_N	17..173	CDD:304627	71/156 (46%)
Arr1	NP_001246073.1	Arrestin_C	192..350	CDD:214976	76/164 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3865
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52566
OrthoDB	1	1.010	-	-		D340461at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11792
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.930