DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Neurochondrin and NCDN

DIOPT Version :9

Sequence 1:	NP_649658.1	Gene:	Neurochondrin / 40796	FlyBaseID:	FBgn0037447	Length:	723	Species:	Drosophila melanogaster
Sequence 2:	NP_001014839.1	Gene:	NCDN / 23154	HGNCID:	17597	Length:	729	Species:	Homo sapiens

Alignment Length:	739	Identity:	207/739 - (28%)
Similarity:	345/739 - (46%)	Gaps:	103/739 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LKGTKSDTEKFAALFMVTKLVKGKDCNAAGKKLLFEAIGFPFLKKLLVSKDLPNDCPPLVYKSVA 79
            |:..|:|:|:||||.:|||.||..|.:|..::.:|:|:||.|..:||.:|:.|:.||..|.:::.
Human    43 LREAKNDSEQFAALLLVTKAVKAGDIDAKTRRRIFDAVGFTFPNRLLTTKEAPDGCPDHVLRALG 107

  Fly    80 LSILTCFCQEEELATHKDIIDAIPTLLEIVEQADDEDYEDNLIVVSEAYSCLKSIASHEPGQQAL 144
            :::|.|||.:.|||.|..:::.||.|...:....|.|......::.:.|.||.::|....|.:.|
Human   108 VALLACFCSDPELAAHPQVLNKIPILSTFLTARGDPDDAARRSMIDDTYQCLTAVAGTPRGPRHL 172

  Fly   145 LATGAIPKMSQIYSAQSFQTDEALHLIVLLVKQFGVVSWPEDPTAFHALIQRIALDMETDDTERK 209
            :|.|.:..:.|.|....:..|:||.|:|.|:.......|.|......|:::.::.|.:..:...|
Human   173 IAGGTVSALCQAYLGHGYGFDQALALLVGLLAAAETQCWKEAEPDLLAVLRGLSEDFQKAEDASK 237

  Fly   210 YELCRIL------ADILITCRREIVINSLEGQIWPESLFKGCGDILKAKIGPKQRDPALHLIATT 268
            :|||::|      ..:...|.|:              |..|...||.:|:...||:|||.|.|..
Human   238 FELCQLLPLFLPPTTVPPECYRD--------------LQAGLARILGSKLSSWQRNPALKLAARL 288

  Fly   269 LHVLGIQWAFMDEQKTFFLQLL-QLGAIEVRMQMDEKKLETTFKQAELLTCCFSILEHCI-EYMA 331
            .|..|..|.......:.||.|| .|..:|||:.::|...|.   :.:::|.|::::|..| |...
Human   289 AHACGSDWIPAGSSGSKFLALLVNLACVEVRLALEETGTEV---KEDVVTACYALMELGIQECTR 350

  Fly   332 TDQLDLEPKEKQTTYTALKGAFNQVLAVLTRVSQDKIRESSNPKDKKFVFAIVKVLSAWLAQETT 396
            .:|..|:..:|....:.:|.|...|:..|.:|..:|.:|       .||||.|::|.||||:||:
Human   351 CEQSLLKEPQKVQLVSVMKEAIGAVIHYLLQVGSEKQKE-------PFVFASVRILGAWLAEETS 408

  Fly   397 AMRPAIYKLLPFMLKVANESFQELK---------------------TWRAGTREGEPPIDVLRIM 440
            ::|..:.:||||:::.|...::|.:                     ||         |.|.||::
Human   409 SLRKEVCQLLPFLVRYAKTLYEEAEEANDLSQQVANLAISPTTPGPTW---------PGDALRLL 464

  Fly   441 LPALCHFAVEEEARRVLFTHKQDEVLLESLEFYFSIAHWKRPPIPRAERLKRMNEP--DPVPTPE 503
            ||..||..||:..|.:|.......:|.:    || :..|:            :..|  |....|:
Human   465 LPGWCHLTVEDGPREILIKEGAPSLLCK----YF-LQQWE------------LTSPGHDTSVLPD 512

  Fly   504 QQAEMKVARSAIVALCNILMNFTVLEPKKAEDGPTFANLLKFVVENLPELKDTPDNLVIHGNLAV 568
            .      ....:...|:|.:|..|..|...:....|.:|:..::.:||.|......|::..|:|.
Human   513 S------VEIGLQTCCHIFLNLVVTAPGLIKRDACFTSLMNTLMTSLPALVQQQGRLLLAANVAT 571

  Fly   569 LGLLLLKQQSKKVKQNDFSICR-YIQATIRFLWDAY--NIDESNDPTALVVSIAYKGYWSDLSEL 630
            ||||:.:..|...........| :..|.|.||..::  .....:|...|.:|..|:|.|:||.||
Human   572 LGLLMARLLSTSPALQGTPASRGFFAAAILFLSQSHVARATPGSDQAVLALSPEYEGIWADLQEL 636

  Fly   631 WFLGMQTMCGVLPLVPWLSEFALESGWAEGIVKTLKKVKIGTLPANVKSAYEDFLSQLVDVNGDV 695
            ||||||...|.:||:|||:..||.|.|.:.:::.|..|...::...:.:||:..|.:|...|
Human   637 WFLGMQAFTGCVPLLPWLAPAALRSRWPQELLQLLGSVSPNSVKPEMVAAYQGVLVELARAN--- 698

  Fly   696 QAVLKKADALRVCRNHRMMDLGKK 719
                      |:||....:..|::
Human   699 ----------RLCREAMRLQAGEE 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Neurochondrin	NP_649658.1	Neurochondrin	2..631	CDD:283244	179/649 (28%)
NCDN	NP_001014839.1	Neurochondrin	30..637	CDD:336138	179/649 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144946
Domainoid	1	1.000	255	1.000	Domainoid score	I2059
eggNOG	1	0.900	-	-		E1_KOG2611
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8064
Inparanoid	1	1.050	299	1.000	Inparanoid score	I2721
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49523
OrthoDB	1	1.010	-	-		D157138at33208
OrthoFinder	1	1.000	-	-		FOG0007454
OrthoInspector	1	1.000	-	-		oto88369
orthoMCL	1	0.900	-	-		OOG6_106255
Panther	1	1.100	-	-	LDO	PTHR13109
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4680
SonicParanoid	1	1.000	-	-		X6328
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800