DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment armc3 and p120ctn

DIOPT Version :9

Sequence 1:	NP_001001246.1	Gene:	armc3 / 407950	XenbaseID:	XB-GENE-971492	Length:	863	Species:	Xenopus tropicalis
Sequence 2:	NP_001036444.1	Gene:	p120ctn / 3355143	FlyBaseID:	FBgn0260799	Length:	781	Species:	Drosophila melanogaster

Alignment Length:	726	Identity:	138/726 - (19%)
Similarity:	260/726 - (35%)	Gaps:	192/726 - (26%)

- Green bases have known domain annotations that are detailed below.

Frog    47 DALYKFAKKGEENKLALLELGAVDPLSKLISHEDKIVRRNATMVCGIMASHYDVRKLLRKLDIIP 111
            |:..:..|...|.||....:.:::.:.:.:..:|..:..:...:|..|      |.....|..:.
  Fly   173 DSQCRTFKSSAEFKLPQFAMSSINTVPQRLEEKDDYIEGSENDICSTM------RWRDPNLSEVI 231

Frog   112 SLIARLTPEEEVVIHEFATL-CLAYMAAEYTSKTQIHELNGLEPLIKLLSSPDPDVKKNCAECIY 175
            |.::  .|...:..:..|.| .|.||  :..:|.:...|.|:.||::|||...|::.||....:.
  Fly   232 SFLS--NPSSAIKANAAAYLQHLCYM--DDPNKQRTRSLGGIPPLVRLLSYDSPEIHKNACGALR 292

Frog   176 LLA---QEFQSRSAVWELNAIPPLLELL-KSEYPVIQQLTLRTLGCLSSEVEARHIFIENQVLEQ 236
            .|:   |..:::..:.....|..|:.|| :|:...:::|....|..:||..:.:...|:..::..
  Fly   293 NLSYGRQNDENKRGIKNAGGIAALVHLLCRSQETEVKELVTGVLWNMSSCEDLKRSIIDEALVAV 357

Frog   237 LLKVLETKEFHDLHVDTLLVIANCLEDVEALHILQQSGGLKRILEFAETTPLPEAQMNAAKAISK 301
            :..|::.....|         |.|..:.....:.:.:.|:.|                   .:|.
  Fly   358 VCSVIKPHSGWD---------AVCCGETCFSTVFRNASGVLR-------------------NVSS 394

Frog   302 AAQNDENRKFFHEQEVERILVSMLDTDNDEVKAAACLAIAAMGENLESKNVFNKQGIPQIITLLT 366
            |.::........|..||                  || :..:..::|..|:.||
  Fly   395 AGEHARGCLRNCEHLVE------------------CL-LYVVRTSIEKNNIGNK----------- 429

Frog   367 RESAEVRESAAFVLANLTTNC--------------------PANASA-----------VAEADGV 400
                 ..|:...:|.||:..|                    |:::..           ..||:..
  Fly   430 -----TVENCVCILRNLSYRCQEVDDPNYDKHPFITPERVIPSSSKGENLGCFGTNKKKKEANNS 489

Frog   401 DAL--INLLSD-KRDGVIMNACTVLINMAAQEPLRLILETHGLVHALIEPLHS-SNNMVLSKAAL 461
            |||  .|:.:| .:..|..|.    :|...::     |....:|...:..|.| ||...|..||.
  Fly   490 DALNEYNISADYSKSSVTYNK----LNKGYEQ-----LWQPEVVQYYLSLLQSCSNPETLEAAAG 545

Frog   462 TVASI-AC----DADIRTDLRNAGGLPPLVKLLQCDHNEVRRSACWAVAVCASDELTAVELYKLG 521
            .:.:: ||    ..|||..:|...|||.||:||:.   ||.|..| |||       ||:.
  Fly   546 AIQNLSACYWQPSIDIRATVRKEKGLPILVELLRM---EVDRVVC-AVA-------TALR----- 594

Frog   522 ALDLLQELNLSRSRRNN--FSEWALNKLLDNNLPLKYSQKGYLSY-SNLIEDGFYDCGRIKPDAK 583
                    ||:..:||.  ..::|:..|: ..||     .|.:.: .|..:|..        .|.
  Fly   595 --------NLAIDQRNKELIGKYAMRDLV-QKLP-----SGNVQHDQNTSDDTI--------TAV 637

Frog   584 LLPLEELSKQELNQNRAVI-------LIN-AKSPDLAPAAVAPPAEEKQESV----GARSSYSRN 636
            |..:.|:.|:....:|:::       |:| .|..:...:.|...|.:...::    ..|..|.:|
  Fly   638 LATINEVIKKNPEFSRSLLDSGGIDRLMNITKRKEKYTSCVLKFASQVLYTMWQHNELRDVYKKN 702

Frog   637 ASREKAGAPAEEKPEQAVVRTPSSHGRSASKEKGSKGKVRLKKEEEKP---------KEEEEVAQ 692
            ..:|:...............:|::...:.::...|:|:.|.   |::.         ...:....
  Fly   703 GWKEQDFVSKHFTAHNTPPSSPNNVNNTLNRPMASQGRTRY---EDRTIQRGTSTLYSANDSSGA 764

Frog   693 FLQNQSLIVSE 703
            .:.|:|.::||
  Fly   765 VMSNESAMLSE 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
armc3	NP_001001246.1	armadillo repeat	62..94	CDD:293788	2/31 (6%)
		armadillo repeat	104..136	CDD:293788	6/32 (19%)
		armadillo repeat	144..179	CDD:293788	11/37 (30%)
		PLN03200	155..>405	CDD:215629	47/286 (16%)
		armadillo repeat	184..218	CDD:293788	7/34 (21%)
		HEAT repeat	276..301	CDD:293787	1/24 (4%)
		HEAT repeat	317..345	CDD:293787	4/27 (15%)
		armadillo repeat	352..383	CDD:293788	4/30 (13%)
		Arm	387..426	CDD:366143	12/72 (17%)
		armadillo repeat	391..427	CDD:293788	10/49 (20%)
		HEAT repeat	435..466	CDD:293787	9/31 (29%)
		ARM	469..504	CDD:214547	15/34 (44%)
		armadillo repeat	473..503	CDD:293788	13/29 (45%)
		EDR1	<712..849	CDD:373038
p120ctn	NP_001036444.1	ARM	227..341	CDD:237987	28/117 (24%)
		armadillo repeat	227..252	CDD:293788	5/26 (19%)
		armadillo repeat	260..296	CDD:293788	12/35 (34%)
		armadillo repeat	304..339	CDD:293788	7/34 (21%)
		ARM	307..442	CDD:237987	30/197 (15%)
		armadillo repeat	347..392	CDD:293788	7/72 (10%)
		armadillo repeat	515..556	CDD:293788	11/45 (24%)
		ARM	516..643	CDD:237987	44/169 (26%)
		armadillo repeat	562..596	CDD:293788	18/57 (32%)
		armadillo repeat	601..641	CDD:293788	11/53 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2332
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030