DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zif and Zkscan8

DIOPT Version :9

Sequence 1:	NP_001189188.1	Gene:	Zif / 40795	FlyBaseID:	FBgn0037446	Length:	388	Species:	Drosophila melanogaster
Sequence 2:	NP_631880.2	Gene:	Zkscan8 / 93681	MGIID:	1913815	Length:	588	Species:	Mus musculus

Alignment Length:	385	Identity:	97/385 - (25%)
Similarity:	154/385 - (40%)	Gaps:	99/385 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 TCRVCLAQSERLQRLDE-----IREEGEESPNEMLIQLLGVSYSNLNDREHIPDGICKSCKVELN 68
            |.|:..|..:.|:|:::     ||||          .||..|..:|| |::.|
Mouse   218 TARLLTAGFQTLERIEDMAVSLIREE----------WLLDPSQKDLN-RDNRP------------ 259

  Fly    69 MAYQFREKALRKQMEIEEYCRELGLLDESDVMMIKEEDGSQQQCDEEMYILEETTTGEEEHQEEK 133
                            |:|.....|            ||..:..::|::..:..:.|.:.|.|..
Mouse   260 ----------------EKYRNMFSL------------DGETRSENKELFPKQGISPGIQPHGEAT 296

  Fly   134 GHEEYLEVDTSDQQECIGDTIEYLEDNYTIEMNSDQTEIVLESEKQYEETPSQQL--ALQEAAKA 196
            .             :|.||.|        :.:...:|:.:|...::::..|:|:.  ...|..|:
Mouse   297 A-------------KCNGDVI--------VGLAHGETQDLLGKLERHQGNPTQERRHKCDECGKS 340

  Fly   197 ----SLKARRGRVRRGLNSLTTSDGTEKGGYICDVCGNFYEKRGRMMEHRRRHDGICQYACELCD 257
                |...|..|:..|          || .|.|.|||..:..|..::.|:..|:.:.:|.|:.|.
Mouse   341 FAQNSGLVRHWRIHTG----------EK-PYQCTVCGKAFSYRSALLSHQDIHNKVKRYHCKECG 394

  Fly   258 AKFQVREQLRKHMYSHTGSKPYKCSFCSRQFFYESVLKSHENVHRGIKPYVCKVCDKAFAYAHSL 322
            ..|.....|..|...|||.|||:|:.|.:.|...:.|..|:.:|.|.:||.|..|.|||:::..|
Mouse   395 KAFSQNTGLILHQRIHTGEKPYQCNQCGKAFSQSAGLILHQRIHSGERPYECNECGKAFSHSSHL 459

  Fly   323 TKHELIHSDIKLYRCDYCNKDFR----LLHHMRQHEETKLHQ-NAVMLAESMKVEMVAEQ 377
            ..|:.||:..|.|.||.|.|.||    |:.|.|.|...|.:: |....|.|.|..::..|
Mouse   460 IGHQRIHTGEKPYECDECGKTFRRSSHLIGHQRSHTGEKPYKCNECGRAFSQKSGLIEHQ 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zif	NP_001189188.1	zf-AD	9..87	CDD:285071	17/82 (21%)
		C2H2 Zn finger	225..245	CDD:275368	6/19 (32%)
		COG5048	<250..369	CDD:227381	45/123 (37%)
		C2H2 Zn finger	253..273	CDD:275368	5/19 (26%)
		zf-H2C2_2	266..288	CDD:290200	10/21 (48%)
		C2H2 Zn finger	281..301	CDD:275368	5/19 (26%)
		zf-H2C2_2	294..318	CDD:290200	11/23 (48%)
		C2H2 Zn finger	309..329	CDD:275368	7/19 (37%)
		C2H2 Zn finger	337..353	CDD:275368	9/19 (47%)
Zkscan8	NP_631880.2	SCAN	48..158	CDD:128708
		KRAB_A-box	233..268	CDD:143639	13/73 (18%)
		COG5048	<322..574	CDD:227381	66/209 (32%)
		C2H2 Zn finger	334..354	CDD:275368	5/19 (26%)
		C2H2 Zn finger	363..382	CDD:275368	5/18 (28%)
		C2H2 Zn finger	390..410	CDD:275368	5/19 (26%)
		C2H2 Zn finger	418..438	CDD:275368	5/19 (26%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..494	CDD:275368	9/19 (47%)
		C2H2 Zn finger	502..522	CDD:275368	5/18 (28%)
		C2H2 Zn finger	530..550	CDD:275368
		C2H2 Zn finger	558..578	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910