DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zif and ZNF845

DIOPT Version :9

Sequence 1:	NP_001189188.1	Gene:	Zif / 40795	FlyBaseID:	FBgn0037446	Length:	388	Species:	Drosophila melanogaster
Sequence 2:	NP_001308451.1	Gene:	ZNF845 / 91664	HGNCID:	25112	Length:	970	Species:	Homo sapiens

Alignment Length:	322	Identity:	89/322 - (27%)
Similarity:	137/322 - (42%)	Gaps:	63/322 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 CKSC----KVELNMAYQFREKALRKQMEIEEYCRELG-LLDESDVMMIKE--EDGSQQ-QCDEEM 116
            |..|    ..||.:....|.....|..:    |.|.| ....:..::|.:  ..|.:. :|:|..
Human   273 CNDCGKTFSQELTLTCHHRLHTGEKHYK----CSECGKTFSRNSALVIHKAIHTGEKSYKCNECG 333

  Fly   117 YILEETT---------TGEEEHQEEKGHEEYLEVDTSDQQECIGDTIEYLEDNYTIEMNSDQTEI 172
            ....:|:         |||:.::.|               ||        :..::.:.|.::...
Human   334 KTFSQTSYLVYHRRLHTGEKPYKCE---------------EC--------DKAFSFKSNLERHRK 375

  Fly   173 VLESEKQYEETPSQQLALQEAAKASLKARRGRVRRGLNSLTTSDGTEKGGYICDVCGNFYEKRGR 237
            :...||.|:   ..:.:...:.|:|| .|..|:..|          || .|.|:.||..:.:...
Human   376 IHTGEKPYK---CNECSRTFSRKSSL-TRHRRLHTG----------EK-PYKCNDCGKTFSQMSS 425

  Fly   238 MMEHRRRHDGICQYACELCDAKFQVREQLRKHMYSHTGSKPYKCSFCSRQFFYESVLKSHENVHR 302
            ::.|||.|.|...|.||.||..|..:..|.:|...|||.|||||:.|.:.|...|.|..|..:|.
Human   426 LVYHRRLHTGEKPYKCEECDEAFSFKSNLERHRRIHTGEKPYKCNDCGKTFSQTSSLVYHRRLHT 490

  Fly   303 GIKPYVCKVCDKAFAYAHSLTKHELIHSDIKLYRCDYCNKDF----RLLHHMRQHEETKLHQ 360
            |.|||.|:.||:||::..:|.:|.:||:..|||:|:.|.|.|    .|..|.|.|...|.:|
Human   491 GEKPYKCEECDEAFSFKSNLERHRIIHTGEKLYKCNECGKTFSRKSSLTRHCRLHTGEKPYQ 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zif	NP_001189188.1	zf-AD	9..87	CDD:285071	6/30 (20%)
		C2H2 Zn finger	225..245	CDD:275368	6/19 (32%)
		COG5048	<250..369	CDD:227381	48/115 (42%)
		C2H2 Zn finger	253..273	CDD:275368	7/19 (37%)
		zf-H2C2_2	266..288	CDD:290200	11/21 (52%)
		C2H2 Zn finger	281..301	CDD:275368	6/19 (32%)
		zf-H2C2_2	294..318	CDD:290200	12/23 (52%)
		C2H2 Zn finger	309..329	CDD:275368	7/19 (37%)
		C2H2 Zn finger	337..353	CDD:275368	7/19 (37%)
ZNF845	NP_001308451.1	KRAB	8..>48	CDD:214630
		KRAB	8..47	CDD:279668
		COG5048	169..564	CDD:227381	89/322 (28%)
		C2H2 Zn finger	217..237	CDD:275368
		C2H2 Zn finger	245..265	CDD:275368
		C2H2 Zn finger	273..293	CDD:275368	5/19 (26%)
		C2H2 Zn finger	301..321	CDD:275368	4/19 (21%)
		C2H2 Zn finger	329..349	CDD:275368	3/19 (16%)
		C2H2 Zn finger	357..377	CDD:275368	4/42 (10%)
		zf-H2C2_2	369..394	CDD:290200	4/27 (15%)
		COG5048	381..813	CDD:227381	67/187 (36%)
		C2H2 Zn finger	385..405	CDD:275368	5/20 (25%)
		zf-H2C2_2	397..422	CDD:290200	11/36 (31%)
		C2H2 Zn finger	413..433	CDD:275368	6/19 (32%)
		C2H2 Zn finger	441..461	CDD:275368	7/19 (37%)
		zf-H2C2_2	453..478	CDD:290200	12/24 (50%)
		C2H2 Zn finger	469..489	CDD:275368	6/19 (32%)
		C2H2 Zn finger	497..517	CDD:275368	7/19 (37%)
		zf-H2C2_2	509..534	CDD:290200	11/24 (46%)
		C2H2 Zn finger	525..545	CDD:275368	7/19 (37%)
		zf-H2C2_2	537..560	CDD:290200	6/16 (38%)
		C2H2 Zn finger	553..573	CDD:275368	89/322 (28%)
		C2H2 Zn finger	581..601	CDD:275368
		C2H2 Zn finger	609..629	CDD:275368
		C2H2 Zn finger	637..657	CDD:275368
		zf-H2C2_2	649..674	CDD:290200
		C2H2 Zn finger	665..685	CDD:275368
		C2H2 Zn finger	693..713	CDD:275368
		C2H2 Zn finger	721..741	CDD:275368
		C2H2 Zn finger	749..769	CDD:275368
		zf-H2C2_2	761..786	CDD:290200
		C2H2 Zn finger	777..797	CDD:275368
		C2H2 Zn finger	805..825	CDD:275368
		C2H2 Zn finger	833..853	CDD:275368
		zf-H2C2_2	845..870	CDD:290200
		C2H2 Zn finger	861..881	CDD:275368
		zf-H2C2_2	873..898	CDD:290200
		C2H2 Zn finger	889..909	CDD:275368
		C2H2 Zn finger	917..937	CDD:275368
		C2H2 Zn finger	945..965	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910