Protein Alignment Zif and ZSCAN9

DIOPT Version :10

• Sequence 1: NP_649657.1
• Gene: Zif / 40795
• FlyBaseID: FBgn0037446
• Length: 388
• Species: Drosophila melanogaster
• Sequence 2: XP_011513177.1
• Gene: ZSCAN9 / 7746
• HGNCID: 12984
• Length: 583
• Species: Homo sapiens
• Alignment Length: 434
• Identity: 92/434 - (21%)
• Similarity: 155/434 - (35%)
• Gaps: 110/434 - (25%)

  Fly    16 QSERLQRLDEIREE------------GEESPNEMLIQLLGVSYSNLNDREHIPDGICKSCKVELN 68
            |..||:|.:.:..|            ....|.|.|.:|..:.|..|  |.|:.   .|...::|.
Human   168 QESRLKRSNPLAREIFRRHFRQLCYQETPGPREALTRLQELCYQWL--RPHVS---TKEQILDLL 227

  Fly    69 MAYQFREKALRKQME--IEEYCRELG------------LLDESDVMMIKEEDGSQQQCDEEMYIL 119
            :..||. ..|.|:::  :.|:|.|.|            .|||....|:......:..|.|.:.:.
Human   228 VLEQFL-SILPKELQGWVREHCPESGEEAVILLEDLERELDEPQHEMVAHRHRQEVLCKEMVPLA 291

  Fly   120 EETTTGEEEHQEEKGHEEYLEVDTSDQQECIGDTIE----------------------------- 155
            |:|....:...:    |..|..|::.:...||:|..
Human   292 EQTPLTLQSQPK----EPQLTCDSAQKCHSIGETAPLWISDLIRSLRRRAVLIPLGAHLFSTDTF 352

  Fly   156 -----------------------YLEDNYTIEMNSDQTEIVLESE---------KQYEETPSQQL 188
                                   .|.|..|   .::..|:||..:         |.:.| .:.::
Human   353 LFSKPVVIPQLKGGGETWPNNRGVLRDEVT---KTEDRELVLRKDCPKIVEPHGKMFNE-QTWEV 413

  Fly   189 ALQEAAKASLKARRGRVRRGLNSLTTSDGTEKGGYICDVCGNFYEKRGRMMEHRRRHDGICQYAC 253
            :.|:.:...:...:.|:.|...:| ..:|..|    ||.||..:.:...::.|:|.|.|...|.|
Human   414 SQQDPSHGEVGEHKDRIERQWGNL-LGEGQHK----CDECGKSFTQSSGLIRHQRIHTGERPYEC 473

  Fly   254 ELCDAKFQVREQLRKHMYSHTGSKPYKCSFCSRQFFYESVLKSHENVHRGIKPYVCKVCDKAFAY 318
            ..|...|.....|..|...|...|.|.|..|.:.|...:.|..|:.:|:|.|||.|..|.|:::.
Human   474 NECGKAFSRSSGLFNHRGIHNIQKRYHCKECGKVFSQSAGLIQHQRIHKGEKPYQCSQCSKSYSR 538

  Fly   319 AHSLTKHELIHSDIKLYRCDYCNKDF----RLLHHMRQHEETKL 358
            ...|.:|:..|:..:.::|..|.|.|    .|:.|.:.|...:|
Human   539 RSFLIEHQRSHTGERPHQCIECGKSFNRHCNLIRHQKIHTVAEL 582

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Zif	NP_649657.1	zf-AD	9..87	CDD:462262	19/84 (23%)
		C2H2 Zn finger	225..245	CDD:275368	6/19 (32%)
		COG5048	<250..369	CDD:227381	33/113 (29%)
		C2H2 Zn finger	253..273	CDD:275368	5/19 (26%)
		C2H2 Zn finger	281..301	CDD:275368	5/19 (26%)
		C2H2 Zn finger	309..329	CDD:275368	5/19 (26%)
		C2H2 Zn finger	337..353	CDD:275368	6/19 (32%)
ZSCAN9	XP_011513177.1	SCAN	180..292	CDD:128708	25/117 (21%)
		COG5048	<442..578	CDD:227381	40/139 (29%)
		C2H2 Zn finger	445..465	CDD:275368	6/19 (32%)
		C2H2 Zn finger	473..493	CDD:275368	5/19 (26%)
		C2H2 Zn finger	501..521	CDD:275368	5/19 (26%)
		C2H2 Zn finger	529..549	CDD:275368	5/19 (26%)
		C2H2 Zn finger	557..577	CDD:275368	6/19 (32%)