DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zif and ZNF43

DIOPT Version :9

Sequence 1:	NP_001189188.1	Gene:	Zif / 40795	FlyBaseID:	FBgn0037446	Length:	388	Species:	Drosophila melanogaster
Sequence 2:	NP_001243582.1	Gene:	ZNF43 / 7594	HGNCID:	13109	Length:	818	Species:	Homo sapiens

Alignment Length:	349	Identity:	87/349 - (24%)
Similarity:	142/349 - (40%)	Gaps:	69/349 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 CKSCKVELNMAYQFREKALRKQMEIEEYCRELG-------LLDESDVMMIKEEDGSQQQCDEEMY 117
            ||.|....|.:....|.......|....|.|.|       .|.:...:...|:..:.::|.:...
Human   297 CKECAKAFNQSSNLTEHKKIHPGEKPYKCEECGKAFNWPSTLTKHKRIHTGEKPYTCEECGKAFN 361

  Fly   118 ILEETTTGEEEHQEEKGHE---------------EYLEVDTSDQ----QECIGDTIEYLEDNYTI 163
            .....||.:..|..||.::               ::.::.|..:    :|| |...::
Human   362 QFSNLTTHKRIHTAEKFYKCTECGEAFSRSSNLTKHKKIHTEKKPYKCEEC-GKAFKW------- 418

  Fly   164 EMNSDQTE--IVLESEKQYEETPSQQLALQEAAKA----SLKARRGRVRRG-------------- 208
              :|..||  :....||.|:        .:|..||    |...:..|:..|
Human   419 --SSKLTEHKLTHTGEKPYK--------CEECGKAFNWPSTLTKHNRIHTGEKPYKCEVCGKAFN 473

  Fly   209 -LNSLTTSD--GTEKGGYICDVCGNFYEKRGRMMEHRRRHDGICQYACELCDAKFQVREQLRKHM 270
             .::|||..  .|.:..|.|:.||..:.:...:.:|::.|.....|.||.|...|:...:|.:|.
Human   474 QFSNLTTHKRIHTAEKPYKCEECGKAFSRSSNLTKHKKIHIEKKPYKCEECGKAFKWSSKLTEHK 538

  Fly   271 YSHTGSKPYKCSFCSRQFFYESVLKSHENVHRGIKPYVCKVCDKAFAYAHSLTKHELIHSDIKLY 335
            .:|||.|||||..|.:.|.:.|:|..|:.:|.|.|||.|:.|.|||..:.:||.|:.||:..|.|
Human   539 ITHTGEKPYKCEECGKAFNHFSILTKHKRIHTGEKPYKCEECGKAFTQSSNLTTHKKIHTGEKFY 603

  Fly   336 RCDYCNKDFRLLHHMRQHEETKLH 359
            :|:.|.|.|....::..|:  |:|
Human   604 KCEECGKAFTQSSNLTTHK--KIH 625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zif	NP_001189188.1	zf-AD	9..87	CDD:285071	6/26 (23%)
		C2H2 Zn finger	225..245	CDD:275368	4/19 (21%)
		COG5048	<250..369	CDD:227381	44/110 (40%)
		C2H2 Zn finger	253..273	CDD:275368	6/19 (32%)
		zf-H2C2_2	266..288	CDD:290200	11/21 (52%)
		C2H2 Zn finger	281..301	CDD:275368	6/19 (32%)
		zf-H2C2_2	294..318	CDD:290200	12/23 (52%)
		C2H2 Zn finger	309..329	CDD:275368	8/19 (42%)
		C2H2 Zn finger	337..353	CDD:275368	4/15 (27%)
ZNF43	NP_001243582.1	KRAB	13..72	CDD:214630
		KRAB	13..52	CDD:279668
		C2H2 Zn finger	158..177	CDD:275370
		C2H2 Zn finger	185..205	CDD:275368
		C2H2 Zn finger	213..233	CDD:275368
		C2H2 Zn finger	241..261	CDD:275368
		C2H2 Zn finger	269..289	CDD:275368
		COG5048	295..763	CDD:227381	87/349 (25%)
		C2H2 Zn finger	297..317	CDD:275368	5/19 (26%)
		zf-H2C2_2	309..333	CDD:290200	5/23 (22%)
		C2H2 Zn finger	325..345	CDD:275368	4/19 (21%)
		zf-H2C2_2	338..362	CDD:290200	3/23 (13%)
		C2H2 Zn finger	353..373	CDD:275368	3/19 (16%)
		C2H2 Zn finger	381..401	CDD:275368	0/19 (0%)
		zf-H2C2_2	393..417	CDD:290200	4/24 (17%)
		C2H2 Zn finger	409..429	CDD:275368	6/29 (21%)
		zf-H2C2_2	422..445	CDD:290200	8/30 (27%)
		C2H2 Zn finger	437..457	CDD:275368	5/19 (26%)
		zf-H2C2_2	450..474	CDD:290200	2/23 (9%)
		C2H2 Zn finger	465..485	CDD:275368	3/19 (16%)
		zf-H2C2_2	477..502	CDD:290200	8/24 (33%)
		C2H2 Zn finger	521..541	CDD:275368	6/19 (32%)
		zf-H2C2_2	534..558	CDD:290200	12/23 (52%)
		C2H2 Zn finger	549..569	CDD:275368	6/19 (32%)
		zf-H2C2_2	562..586	CDD:290200	12/23 (52%)
		C2H2 Zn finger	577..597	CDD:275368	8/19 (42%)
		zf-H2C2_2	589..614	CDD:290200	11/24 (46%)
		C2H2 Zn finger	605..625	CDD:275368	6/21 (29%)
		zf-H2C2_2	617..642	CDD:290200	3/11 (27%)
		C2H2 Zn finger	633..653	CDD:275368
		C2H2 Zn finger	661..681	CDD:275368
		zf-H2C2_2	674..697	CDD:290200
		C2H2 Zn finger	689..709	CDD:275368
		zf-H2C2_2	702..726	CDD:290200
		C2H2 Zn finger	717..737	CDD:275368
		zf-H2C2_2	729..754	CDD:290200
		COG5048	742..>803	CDD:227381
		C2H2 Zn finger	745..765	CDD:275368
		zf-H2C2_2	757..782	CDD:290200
		C2H2 Zn finger	773..793	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910