Protein Alignment Zif and ZKSCAN7

DIOPT Version :10

• Sequence 1: NP_649657.1
• Gene: Zif / 40795
• FlyBaseID: FBgn0037446
• Length: 388
• Species: Drosophila melanogaster
• Sequence 2: NP_061121.2
• Gene: ZKSCAN7 / 55888
• HGNCID: 12955
• Length: 754
• Species: Homo sapiens
• Alignment Length: 260
• Identity: 73/260 - (28%)
• Similarity: 120/260 - (46%)
• Gaps: 33/260 - (12%)

  Fly   112 CDEEMYILEETTTGEEEHQEEKGHEEYLEVDTSDQQECIGDTIE-YLE--DNYTIEMNSDQTEIV 173
            |::....||..|:.||..:.|   .::||:...|:::...|..: |.|  ::..:..:..:.|.|
Human   315 CEDTFKELEGQTSDEEGSRLE---NDFLEITDEDKKKSTKDRYDKYKEVGEHPPLSSSPVEHEGV 376

  Fly   174 LESEKQYEETPSQQLALQEAAKASLKAR----RGRVRRGLNSLTTSDGTEKGGYICDVCGNFYEK 234
            |:.:|.|.        ..|..||..::.    ..|:..|          || .|.|:.||..:.:
Human   377 LKGQKSYR--------CDECGKAFNRSSHLIGHQRIHTG----------EK-PYECNECGKTFRQ 422

  Fly   235 RGRMMEHRRRHDGICQYACELCDAKFQVREQLRKHMYSHTGSKPYKCSFCSRQFFYESVLKSHEN 299
            ..:::.|.|.|.|...|.|..|...::....|.:|...|.|.|||||:.|::.|...|.|..|:.
Human   423 TSQLIVHLRTHTGEKPYECSECGKAYRHSSHLIQHQRLHNGEKPYKCNECAKAFTQSSRLTDHQR 487

  Fly   300 VHRGIKPYVCKVCDKAFAYAHSLTKHELIHSDIKLYRCDYCNKDF----RLLHHMRQHEETKLHQ 360
            .|.|.|||.|..|.:||..:.||.:|:::|:..|.|:|:.|.:.|    .|:.|.|.|...|.::
Human   488 THTGEKPYECNECGEAFIRSKSLARHQVLHTGKKPYKCNECGRAFCSNRNLIDHQRIHTGEKPYE 552

  Fly   361  360
            Human   553  552

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Zif	NP_649657.1	zf-AD	9..87	CDD:462262
		C2H2 Zn finger	225..245	CDD:275368	5/19 (26%)
		COG5048	<250..369	CDD:227381	40/115 (35%)
		C2H2 Zn finger	253..273	CDD:275368	4/19 (21%)
		C2H2 Zn finger	281..301	CDD:275368	6/19 (32%)
		C2H2 Zn finger	309..329	CDD:275368	7/19 (37%)
		C2H2 Zn finger	337..353	CDD:275368	6/19 (32%)
ZKSCAN7	NP_061121.2	SCAN	51..161	CDD:128708
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	157..215
		KRAB_A-box	231..270	CDD:143639
		COG5048	380..738	CDD:227381	57/192 (30%)
		C2H2 Zn finger	385..405	CDD:275368	4/19 (21%)
		C2H2 Zn finger	413..433	CDD:275368	5/19 (26%)
		C2H2 Zn finger	441..461	CDD:275368	4/19 (21%)
		C2H2 Zn finger	469..489	CDD:275368	6/19 (32%)
		C2H2 Zn finger	497..517	CDD:275368	7/19 (37%)
		C2H2 Zn finger	525..545	CDD:275368	6/19 (32%)
		C2H2 Zn finger	553..573	CDD:275368	73/260 (28%)
		C2H2 Zn finger	581..601	CDD:275368
		C2H2 Zn finger	609..629	CDD:275368
		C2H2 Zn finger	637..657	CDD:275368
		C2H2 Zn finger	665..685	CDD:275368
		C2H2 Zn finger	693..713	CDD:275368
		C2H2 Zn finger	721..741	CDD:275368
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	735..754