DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zif and M1BP

DIOPT Version :9

Sequence 1:	NP_001189188.1	Gene:	Zif / 40795	FlyBaseID:	FBgn0037446	Length:	388	Species:	Drosophila melanogaster
Sequence 2:	NP_649825.1	Gene:	M1BP / 41042	FlyBaseID:	FBgn0037621	Length:	418	Species:	Drosophila melanogaster

Alignment Length:	431	Identity:	120/431 - (27%)
Similarity:	190/431 - (44%)	Gaps:	88/431 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 TCRVC--LAQSERLQRLDEIREEGEESPNEMLIQLLGVSYSNLNDREHIPDGICKSCKVELNMAY 71
            |||||  .|.::|..:|      .|.|..:|:..:..::...|.:...:||.||:.|.:||..|.
  Fly    12 TCRVCAKYASNKRSPKL------FERSNTKMIDNIEALTGLRLENYGCLPDQICECCSMELASAV 70

  Fly    72 QFREKALRKQMEIEEYCRELGLLDE---------------SDVMMI------------------- 102
            :.||:.:..|.|:     .|||.:|               .|::..
  Fly    71 KLRERCIAAQREL-----LLGLTEEQRQGISAFYRAAVMGEDIVQTVKTPDDDEVYATYQEIVLE 130

  Fly   103 --KEE-DGSQQQCDEEMYILEETTTGEEE-------------HQEEKGHEEYLEVDTSDQQECIG 151
              ||| |.::.:.|...|.:.|...||::             ..|::..::.||:| .|.:..:|
  Fly   131 EPKEEIDDTKVEYDNTYYEVAEGHAGEDDAASLIEEADYDSIMAEDEEQQQTLELD-EDTELIVG 194

  Fly   152 DTIEYLEDNYTIEMNSDQTEI---VLESEKQYEETPSQQLALQEAAKASLKARRGRVRRGLNSLT 213
            |    :.|.|..: :.|:..:   ||:.|.::|....::.:|....|......|   |||..
  Fly   195 D----VNDAYVYD-SDDEVAVLDNVLDDEYEHENIVVKKCSLPPKPKVRSDDAR---RRGTG--- 248

  Fly   214 TSDGTEKGGYICDVCGNFYEKRGRMMEHRRRHDGICQYACELCDAKFQVREQLRKHMYSHTGSKP 278
                   |.|||:.|||..:.|.....|.|||.|..|:.||||.::|....:|::||..|||.:|
  Fly   249 -------GVYICEQCGNHIKGRMAFELHCRRHRGDKQFGCELCQSRFCTTSELKRHMRKHTGERP 306

  Fly   279 YKCSFCSRQFFYESVLKSHENVHRGIKPYVCKVCDKAFAYAHSLTKHELIHSDIKLYRCDYCNKD 343
            :.|.:|.|.|...:....||..|...:||||..|.|||...:.|..|.||||..:.|||:.|:|.
  Fly   307 FACKYCGRCFTDYTTRVKHERTHTNERPYVCGTCGKAFTTGYILKNHMLIHSGERAYRCELCDKS 371

  Fly   344 FRLLHHMRQHEETKLHQNAVMLAESMKVEMVAEQGGGNEIR 384
            |.|..|:..|..:.:|:..:   |..:::.|.||....|::
  Fly   372 FMLPTHLSTHFRSGVHKRHL---EKAEMKQVLEQEQKRELK 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zif	NP_001189188.1	zf-AD	9..87	CDD:285071	24/79 (30%)
		C2H2 Zn finger	225..245	CDD:275368	7/19 (37%)
		COG5048	<250..369	CDD:227381	45/118 (38%)
		C2H2 Zn finger	253..273	CDD:275368	8/19 (42%)
		zf-H2C2_2	266..288	CDD:290200	10/21 (48%)
		C2H2 Zn finger	281..301	CDD:275368	6/19 (32%)
		zf-H2C2_2	294..318	CDD:290200	11/23 (48%)
		C2H2 Zn finger	309..329	CDD:275368	8/19 (42%)
		C2H2 Zn finger	337..353	CDD:275368	6/15 (40%)
M1BP	NP_649825.1	zf-AD	13..84	CDD:214871	23/81 (28%)
		C2H2 Zn finger	253..273	CDD:275368	7/19 (37%)
		COG5048	276..>331	CDD:227381	20/54 (37%)
		C2H2 Zn finger	281..301	CDD:275368	8/19 (42%)
		zf-H2C2_2	293..317	CDD:290200	10/23 (43%)
		C2H2 Zn finger	309..329	CDD:275368	6/19 (32%)
		zf-H2C2_2	324..346	CDD:290200	11/21 (52%)
		C2H2 Zn finger	337..357	CDD:275368	8/19 (42%)
		zf-H2C2_2	350..372	CDD:290200	11/21 (52%)
		C2H2 Zn finger	365..383	CDD:275368	7/17 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	62	1.000	Inparanoid score	I2531
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.960