DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zif and ouib

DIOPT Version :9

Sequence 1:	NP_001189188.1	Gene:	Zif / 40795	FlyBaseID:	FBgn0037446	Length:	388	Species:	Drosophila melanogaster
Sequence 2:	NP_649822.2	Gene:	ouib / 41039	FlyBaseID:	FBgn0037618	Length:	312	Species:	Drosophila melanogaster

Alignment Length:	358	Identity:	91/358 - (25%)
Similarity:	146/358 - (40%)	Gaps:	63/358 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 CRVCLAQ---SERLQRLDEIREEGEESPNEMLIQLLGVSYSNLNDREHIPDGICKSCKVELNMAY 71
            ||||..|   .:.|...|.:.       .:.|..|..:|...|.|.:.:|..:|..|:.||..|.
  Fly     6 CRVCGRQKICEKSLNLFDLVN-------RKYLKHLHMISGLRLVDLDDVPGFMCLCCQAELRSAL 63

  Fly    72 QFREKALRKQMEIEEYCRELGLLDESDVMMIKEEDGSQQQCDEEMYILEETTTGEEEHQEEKGHE 136
            .||:..::.|.:                .:..|:|.|..         :|.|....|.:.||.
  Fly    64 AFRKLCIKTQTK----------------WLTIEDDSSSG---------DEDTNDNSELESEKC-- 101

  Fly   137 EYLEVDTSDQQECIGDTIEYL--EDNYTIEMNSDQTEIVLESEKQYEETPSQQLALQEAAKASLK 199
            .:.:.....:.|.:.:|.:.|  |:.....:|.|....:.|.....:..|||::     .|.|.|
  Fly   102 AFSDFGKKKEGELVEETFQVLIEEEPMDKTLNRDAKAQLREDGIDEKCVPSQKI-----IKVSTK 161

  Fly   200 ARRGRVRRGLNSLTTSDGTEKGGYICDVCGNFYEKRGRMMEHRRRHDGICQYACELCDAKFQVRE 264
                              .:...|||::||.....:.....|.|:|.|...:.|:.|||:|....
  Fly   162 ------------------LDDQIYICELCGTHATSKPTFQRHMRKHRGERPFGCKDCDARFLSAG 208

  Fly   265 QLRKHMYSHTGSKPYKCSFCSRQFFYESVLKSHENVHRGIKPYVCKVCDKAFAYAHSLTKHELIH 329
            :||.|...|||.:|:.|.||.:::........||..|...:||||:.|.|.|..|:.|..|.:||
  Fly   209 ELRAHHRVHTGEQPFACRFCEKRYVSYMGRLIHERTHTNDRPYVCEECGKKFTTAYVLKNHMVIH 273

  Fly   330 SDIKLYRCDYCNKDFRLLHHMRQHEETKLH-QN 361
            :..:.:|||.|::.|:...|:..|..:.:| ||
  Fly   274 TGERNFRCDICDRSFQRKAHLVTHTRSMMHLQN 306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zif	NP_001189188.1	zf-AD	9..87	CDD:285071	21/79 (27%)
		C2H2 Zn finger	225..245	CDD:275368	5/19 (26%)
		COG5048	<250..369	CDD:227381	40/113 (35%)
		C2H2 Zn finger	253..273	CDD:275368	8/19 (42%)
		zf-H2C2_2	266..288	CDD:290200	10/21 (48%)
		C2H2 Zn finger	281..301	CDD:275368	5/19 (26%)
		zf-H2C2_2	294..318	CDD:290200	10/23 (43%)
		C2H2 Zn finger	309..329	CDD:275368	7/19 (37%)
		C2H2 Zn finger	337..353	CDD:275368	5/15 (33%)
ouib	NP_649822.2	zf-AD	5..78	CDD:214871	21/94 (22%)
		COG5048	<158..300	CDD:227381	48/159 (30%)
		C2H2 Zn finger	169..189	CDD:275368	5/19 (26%)
		C2H2 Zn finger	197..217	CDD:275368	8/19 (42%)
		zf-H2C2_2	209..234	CDD:290200	10/24 (42%)
		C2H2 Zn finger	225..245	CDD:275368	5/19 (26%)
		zf-H2C2_2	241..262	CDD:290200	10/20 (50%)
		C2H2 Zn finger	253..273	CDD:275368	7/19 (37%)
		zf-H2C2_2	266..288	CDD:290200	8/21 (38%)
		C2H2 Zn finger	281..299	CDD:275368	6/17 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	62	1.000	Inparanoid score	I2531
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.960