DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Zif and nom

DIOPT Version :9

Sequence 1:NP_001189188.1 Gene:Zif / 40795 FlyBaseID:FBgn0037446 Length:388 Species:Drosophila melanogaster
Sequence 2:NP_001262384.1 Gene:nom / 41038 FlyBaseID:FBgn0037617 Length:370 Species:Drosophila melanogaster


Alignment Length:373 Identity:89/373 - (23%)
Similarity:154/373 - (41%) Gaps:63/373 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 CRVCLAQSERLQRLDEIREEGEESPNEMLIQLLGVSYSNLNDREHIPDGICKSCKVELNMAYQFR 74
            |||| .:|....:..|:.:.|.:.....:..:.|:.   |....:.||.:|..|:.:|..|..||
  Fly     6 CRVC-GRSRLCPKAVELFKPGRQDILRRIQLITGIL---LQQIPNAPDMVCFCCQTDLQSAMIFR 66

  Fly    75 EKALRKQMEIEEYCRELGLLDESDVMMIKEEDGSQQQCDEEMYILEETTTGEEEHQEEKGHEEY- 138
            .:.:.:|.      :.:.|| :||.:...||...:.         .:.:|.::..:..:|.... 
  Fly    67 RQCILQQK------KWVPLL-QSDKVGASEEKKVEP---------NDPSTKKKTTKRRRGRPRMP 115

  Fly   139 LE----VDTSDQQECIGDTIEYLEDNYTIEMNSDQTEIVLESEKQYEETPSQQLALQEAAKASLK 199
            ||    |.|::.:...|:::...|.:..:|::::..  ..:|:...||.                
  Fly   116 LEIVDIVVTNESKASAGESVGGDEFDQPVEISNEPD--ATDSDVNLEEI---------------- 162

  Fly   200 ARRGRVRRGLNSLTTSDGTEKGG-------YICDVCGNFYEKRGRMMEHRRRHDGICQYACELCD 257
                       .|...||.|...       :.||.||.....:..::.|:..|:||..|.|:.|.
  Fly   163 -----------DLPDEDGLESDHDLPNVQIHKCDTCGIIKNNKSSLVRHQFEHNGIRPYPCKECP 216

  Fly   258 AKFQVREQLRKH-MYSHTGSKPYKCSFCSRQFFYESVLKSHENVHRGIKPYVCKVCDKAFAYAHS 321
            ..|.|..:|:.| :..||...|:.|.:|.|::|.....|.||.||...:|:||..|.|||.....
  Fly   217 KTFLVASELKAHNLTHHTLEPPFACRYCDRRYFSVVGRKKHERVHTNERPFVCDQCGKAFTRTCI 281

  Fly   322 LTKHELIHSDIKLYRCDYCNKDFRLLHHMRQHEETKLH-QNAVMLAES 368
            |..|..:|..::.|.||.|::.|.|..|:..|..:..| :||..:..|
  Fly   282 LKAHMAVHQVVRKYSCDVCDRSFSLKKHLATHFISNTHKRNAEAVTSS 329

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ZifNP_001189188.1 zf-AD 9..87 CDD:285071 18/76 (24%)
C2H2 Zn finger 225..245 CDD:275368 5/19 (26%)
COG5048 <250..369 CDD:227381 41/121 (34%)
C2H2 Zn finger 253..273 CDD:275368 6/20 (30%)
zf-H2C2_2 266..288 CDD:290200 8/22 (36%)
C2H2 Zn finger 281..301 CDD:275368 7/19 (37%)
zf-H2C2_2 294..318 CDD:290200 12/23 (52%)
C2H2 Zn finger 309..329 CDD:275368 7/19 (37%)
C2H2 Zn finger 337..353 CDD:275368 6/15 (40%)
nomNP_001262384.1 zf-AD 5..76 CDD:214871 18/79 (23%)
C2H2 Zn finger 184..204 CDD:275368 5/19 (26%)
C2H2 Zn finger 212..261 CDD:275368 16/48 (33%)
zf-H2C2_2 255..278 CDD:290200 12/22 (55%)
C2H2 Zn finger 269..289 CDD:275368 7/19 (37%)
zf-H2C2_2 282..305 CDD:290200 7/22 (32%)
C2H2 Zn finger 297..313 CDD:275368 6/15 (40%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 50 1.000 Domainoid score I11351
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 62 1.000 Inparanoid score I2531
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
32.960

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