DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zif and ZNF888

DIOPT Version :9

Sequence 1:	NP_001189188.1	Gene:	Zif / 40795	FlyBaseID:	FBgn0037446	Length:	388	Species:	Drosophila melanogaster
Sequence 2:	XP_016882287.1	Gene:	ZNF888 / 388559	HGNCID:	38695	Length:	830	Species:	Homo sapiens

Alignment Length:	385	Identity:	101/385 - (26%)
Similarity:	155/385 - (40%)	Gaps:	79/385 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 SNLNDREHIPDG----ICKSC-KVELNMAYQFR----------------EKALRKQMEIEEY--- 87
            |||.....:..|    .||.| ||....:|..|                :||.|....:.::
Human   451 SNLARHHRVHTGEKPYQCKECDKVFSRKSYLERHRRIHTGEKPYKCKVCDKAFRHDSHLAQHIVI 515

  Fly    88 --------CRELG-LLDESDVMMIKE--EDGSQ-QQCDEEMYILEETT---------TGEEEHQ- 130
                    |.|.| ...|:..:::.:  ..|.: .:|:|...:..:.:         |||:.::
Human   516 HTREKPYKCNECGKTFGENSALLVHKTIHTGEKPYKCNECGKVFNQQSNLARHHRLHTGEKPYKC 580

  Fly   131 -------EEKGH-EEYLEVDTSDQ-QECIGDTIEYLEDNYTIEMNSDQTEIVLESEKQYEETPSQ 186
                   ..|.| |.:..:.|.:: .:|     :..:..:..:.:..|..::...||.|:.....
Human   581 KECDKVFSRKSHLERHRRIHTGEKPYKC-----KVCDKAFRRDSHLAQHTVIHTGEKPYKCNECG 640

  Fly   187 QLALQEAAKASLKA-RRGRVRRGLNSLTTSDG------------TEKGGYICDVCGNFYEKRGRM 238
            :..:|.::....|. ..|..|...|....|..            |.:..|.|:.||..:..:.::
Human   641 KTFVQNSSLVMHKVIHTGEKRYKCNECGKSFNHKSSLAYHHRLHTGEKPYKCNECGKVFRTQSQL 705

  Fly   239 MEHRRRHDGICQYACELCDAKFQVREQLRKHMYSHTGSKPYKCSFCSRQFFYESVLKSHENVHRG 303
            ..|.|.|.|...|.||.||..|.::..|..|...|||.|||||..|.:.|..:|.|..|:.||.|
Human   706 ACHHRLHTGEKPYKCEECDKVFNIKSHLEIHRRVHTGEKPYKCRVCDKAFGRDSYLAQHQRVHTG 770

  Fly   304 IKPYVCKVCDKAF-AYAHSLTKHELIHSDIKLYRCDYCNKDFR----LLHHMRQHEETKL 358
            .|||.|||||||| .|:| |.:|..||:..|.::|..|.|.||    |:||...|...||
Human   771 EKPYKCKVCDKAFKCYSH-LAQHTRIHTGEKPFKCSECGKAFRAQSTLIHHQAIHGVGKL 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zif	NP_001189188.1	zf-AD	9..87	CDD:285071	14/60 (23%)
		C2H2 Zn finger	225..245	CDD:275368	5/19 (26%)
		COG5048	<250..369	CDD:227381	53/114 (46%)
		C2H2 Zn finger	253..273	CDD:275368	7/19 (37%)
		zf-H2C2_2	266..288	CDD:290200	11/21 (52%)
		C2H2 Zn finger	281..301	CDD:275368	6/19 (32%)
		zf-H2C2_2	294..318	CDD:290200	16/24 (67%)
		C2H2 Zn finger	309..329	CDD:275368	12/20 (60%)
		C2H2 Zn finger	337..353	CDD:275368	8/19 (42%)
ZNF888	XP_016882287.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000