DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zif and CG17328

DIOPT Version :9

Sequence 1:	NP_001189188.1	Gene:	Zif / 40795	FlyBaseID:	FBgn0037446	Length:	388	Species:	Drosophila melanogaster
Sequence 2:	NP_609786.2	Gene:	CG17328 / 34962	FlyBaseID:	FBgn0028895	Length:	413	Species:	Drosophila melanogaster

Alignment Length:	351	Identity:	84/351 - (23%)
Similarity:	141/351 - (40%)	Gaps:	78/351 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 CRVCLAQSERLQRLDEI-REEGEESPNEMLIQLLGVSYSNLNDREHIPDGICKSCKVELNMAYQF 73
            |||||   |.|..:..| ..:....|:.||:|...:   .:...:.:|..||.:|...|.:|:.|
  Fly     9 CRVCL---EELHPVTSIYSTDFAMMPSVMLMQCAKI---RVFKTDGLPSVICNNCIYRLGVAFHF 67

  Fly    74 REKALRKQMEIEEYCRELGLLDESDVMMIKEEDGSQQQCDEEMYILEETTTGEEEHQEEKGHEEY 138
            :::.....:.:.:|   ||:|:.      ..:|.:......|..:|.:..:.|||..:.|
  Fly    68 KQECENSDLRLRQY---LGILES------WRQDAATNTDFVEKPLLPQRDSDEEEPVDAK----- 118

  Fly   139 LEVDTSDQQECIGDTIEYLEDNYTIEMNSDQTEIVLESEKQYEETPSQQLALQEAAKASLKARRG 203
                                              |.:...:|:..|.::
  Fly   119 ----------------------------------VSKRRSRYQRKPPEE---------------- 133

  Fly   204 RVRRGLNSLTTSDGTEKGGYICDVCGNFYEKRGRMMEHRRRHDGICQYACELCDAKFQVREQLRK 268
            ..:||...:      .|..:.|..|...::...::.:|.|.|.|...|.|..|..:|..:..|:.
  Fly   134 HKKRGPKPV------PKMPHTCYECHKSFKCIAQLTQHIRTHTGEKPYQCSFCIQRFAQKYNLKV 192

  Fly   269 HMYSHTGSKPYKCSFCSRQFFYESVLKSHENVHRGIKPYVCKVCDKAFAYAHSLTKHELIHSDIK 333
            |..:|||.||::|..||:||......::|:.:|.|::..||.:|.|.|..|..|:||.:.|:.||
  Fly   193 HERTHTGDKPFQCEICSKQFSALGNFQAHQKIHLGVRDQVCSLCQKGFYTAGDLSKHMITHTGIK 257

  Fly   334 LYRCDYCNKDFRLLHHMRQHEETKLH 359
            .:.||.|.|.|.....||.| :.|||
  Fly   258 NHHCDVCGKAFSRRRDMRTH-KLKLH 282

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zif	NP_001189188.1	zf-AD	9..87	CDD:285071	19/77 (25%)
		C2H2 Zn finger	225..245	CDD:275368	4/19 (21%)
		COG5048	<250..369	CDD:227381	42/110 (38%)
		C2H2 Zn finger	253..273	CDD:275368	5/19 (26%)
		zf-H2C2_2	266..288	CDD:290200	10/21 (48%)
		C2H2 Zn finger	281..301	CDD:275368	6/19 (32%)
		zf-H2C2_2	294..318	CDD:290200	8/23 (35%)
		C2H2 Zn finger	309..329	CDD:275368	8/19 (42%)
		C2H2 Zn finger	337..353	CDD:275368	7/15 (47%)
CG17328	NP_609786.2	zf-AD	8..80	CDD:214871	19/76 (25%)
		COG5048	146..>211	CDD:227381	20/64 (31%)
		C2H2 Zn finger	149..169	CDD:275368	4/19 (21%)
		C2H2 Zn finger	177..197	CDD:275368	5/19 (26%)
		zf-H2C2_2	189..213	CDD:404364	11/23 (48%)
		C2H2 Zn finger	205..225	CDD:275368	6/19 (32%)
		C2H2 Zn finger	233..253	CDD:275368	8/19 (42%)
		zf-H2C2_2	245..270	CDD:404364	11/24 (46%)
		C2H2 Zn finger	261..282	CDD:275368	9/21 (43%)
		C2H2 Zn finger	318..338	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910