DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Zif and ZNF850

DIOPT Version :9

Sequence 1:	NP_001189188.1	Gene:	Zif / 40795	FlyBaseID:	FBgn0037446	Length:	388	Species:	Drosophila melanogaster
Sequence 2:	NP_001180481.1	Gene:	ZNF850 / 342892	HGNCID:	27994	Length:	1090	Species:	Homo sapiens

Alignment Length:	407	Identity:	105/407 - (25%)
Similarity:	155/407 - (38%)	Gaps:	101/407 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 PQTCRVCLAQSERLQ-RLDEIRE-EGEESPNEMLIQLLG---VSYSNLNDREHIPDG----ICKS 62
            |..|:.| .::.||: ||.:.:: ...|.|.:  .|..|   ||.|.|.....|..|    .|..
Human   616 PYDCKEC-GKAFRLRLRLTQHQQIHTGEKPYQ--CQECGKAFVSVSGLTQHHRIHTGEKPYECPD 677

  Fly    63 CKVELNMAYQFREKALRKQMEIEEY-----------CRELGLLDESDVMMIKEEDGSQQQCDEEM 116
            |           .||.|::..:.::           |:|.|........:|:.:   |...||:.
Human   678 C-----------GKAFRQRTYLNQHRRIHTGEKPYECKECGKSFTFCSGLIQHQ---QNHTDEKP 728

  Fly   117 YILEETTTGEE------------EHQE-EKGHEEYLEVDTSDQQECIGDTIEYLEDNYTIEMNSD 168
            |      .|:|            :||: ..|.:.|      |.:||        ..::|......
Human   729 Y------DGKECGKSFTSHSTLIQHQQIHTGEKPY------DCKEC--------GKSFTSHSTLI 773

  Fly   169 QTEIVLESEKQYE--------------------ETPSQQLALQEAAKASLKARRGRVR-RGLNSL 212
            |.:.:...||.|:                    .|..:....:|..| |...|...:: |.::
Human   774 QHQQIHTGEKLYDCKECGKSFTSHSTLIQHQPLHTGEKPYHCKECGK-SFTLRSALIQHRPVH-- 835

  Fly   213 TTSDGTEKGGYICDVCGNFYEKRGRMMEHRRRHDGICQYACELCDAKFQVREQLRKHMYSHTGSK 277
                 |.:..|.|..||..:..|..::||:|.|.|...|.|:.|...|..|..:.:|...|||.|
Human   836 -----TGEKRYSCKECGKSFTSRSTLIEHQRIHTGEKPYHCKECGKSFAFRSAIIQHRRIHTGEK 895

  Fly   278 PYKCSFCSRQFFYESVLKSHENVHRGIKPYVCKVCDKAFAYAHSLTKHELIHSDIKLYRCDYCNK 342
            ||.|..|.:.|...|.|..|:.:|.|.|||.|..|.|||.....||||..||:..|.|.|..|.|
Human   896 PYDCKECGKAFRRRSKLTQHQRIHTGEKPYRCHECGKAFVRFSGLTKHHSIHTGEKPYECKTCGK 960

  Fly   343 DFRLLHHMRQHEETKLH 359
            .||...|:..|:  ::|
Human   961 SFRQRTHLTLHQ--RIH 975

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zif	NP_001189188.1	zf-AD	9..87	CDD:285071	21/86 (24%)
		C2H2 Zn finger	225..245	CDD:275368	7/19 (37%)
		COG5048	<250..369	CDD:227381	44/110 (40%)
		C2H2 Zn finger	253..273	CDD:275368	5/19 (26%)
		zf-H2C2_2	266..288	CDD:290200	9/21 (43%)
		C2H2 Zn finger	281..301	CDD:275368	6/19 (32%)
		zf-H2C2_2	294..318	CDD:290200	12/23 (52%)
		C2H2 Zn finger	309..329	CDD:275368	9/19 (47%)
		C2H2 Zn finger	337..353	CDD:275368	6/15 (40%)
ZNF850	NP_001180481.1	KRAB	7..67	CDD:214630
		KRAB	7..46	CDD:279668
		C2H2 Zn finger	199..219	CDD:275368
		C2H2 Zn finger	227..244	CDD:275368
		COG5048	243..659	CDD:227381	13/45 (29%)
		C2H2 Zn finger	255..275	CDD:275368
		C2H2 Zn finger	283..303	CDD:275368
		zf-H2C2_2	296..319	CDD:290200
		C2H2 Zn finger	311..331	CDD:275368
		zf-H2C2_2	324..348	CDD:290200
		C2H2 Zn finger	339..359	CDD:275368
		zf-H2C2_2	351..375	CDD:290200
		C2H2 Zn finger	367..387	CDD:275368
		zf-H2C2_2	379..403	CDD:290200
		C2H2 Zn finger	395..415	CDD:275368
		C2H2 Zn finger	423..443	CDD:275368
		zf-H2C2_2	436..460	CDD:290200
		C2H2 Zn finger	451..471	CDD:275368
		zf-H2C2_2	463..487	CDD:290200
		C2H2 Zn finger	479..499	CDD:275368
		zf-H2C2_2	493..516	CDD:290200
		C2H2 Zn finger	507..527	CDD:275368
		zf-H2C2_2	519..543	CDD:290200
		COG5048	531..947	CDD:227381	93/375 (25%)
		C2H2 Zn finger	535..555	CDD:275368
		C2H2 Zn finger	563..583	CDD:275368
		zf-H2C2_2	575..599	CDD:290200
		C2H2 Zn finger	591..611	CDD:275368
		C2H2 Zn finger	619..639	CDD:275368	6/20 (30%)
		zf-H2C2_2	632..656	CDD:290200	5/25 (20%)
		C2H2 Zn finger	647..667	CDD:275368	6/19 (32%)
		zf-H2C2_2	660..684	CDD:290200	7/34 (21%)
		C2H2 Zn finger	675..695	CDD:275368	5/30 (17%)
		zf-H2C2_2	687..711	CDD:290200	3/23 (13%)
		C2H2 Zn finger	703..723	CDD:275368	5/22 (23%)
		C2H2 Zn finger	732..751	CDD:275368	3/18 (17%)
		C2H2 Zn finger	759..779	CDD:275368	4/27 (15%)
		C2H2 Zn finger	787..807	CDD:275368	0/19 (0%)
		C2H2 Zn finger	815..835	CDD:275368	5/20 (25%)
		C2H2 Zn finger	843..863	CDD:275368	7/19 (37%)
		zf-H2C2_2	856..879	CDD:290200	8/22 (36%)
		C2H2 Zn finger	871..891	CDD:275368	5/19 (26%)
		C2H2 Zn finger	899..919	CDD:275368	6/19 (32%)
		zf-H2C2_2	912..936	CDD:290200	12/23 (52%)
		C2H2 Zn finger	927..947	CDD:275368	9/19 (47%)
		C2H2 Zn finger	955..975	CDD:275368	7/21 (33%)
		zf-H2C2_2	967..992	CDD:290200	3/11 (27%)
		C2H2 Zn finger	983..1003	CDD:275368
		zf-H2C2_2	995..1020	CDD:290200
		C2H2 Zn finger	1011..1031	CDD:275368
		zf-H2C2_2	1024..1046	CDD:290200
		C2H2 Zn finger	1039..1059	CDD:275368
		zf-H2C2_2	1052..1076	CDD:290200
		C2H2 Zn finger	1067..1087	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910