DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zif and prg

DIOPT Version :9

Sequence 1:	NP_001189188.1	Gene:	Zif / 40795	FlyBaseID:	FBgn0037446	Length:	388	Species:	Drosophila melanogaster
Sequence 2:	NP_001260253.1	Gene:	prg / 34177	FlyBaseID:	FBgn0285971	Length:	558	Species:	Drosophila melanogaster

Alignment Length:	378	Identity:	94/378 - (24%)
Similarity:	160/378 - (42%)	Gaps:	68/378 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 TCRVCLAQSE--RLQRLDE-IREEGEESPNEMLIQLLGVSYSNLNDR-EHIPDGICKSCKVELNM 69
            |||:|...::  .|...|: ::...:.|..|:...|..|.|    || |.:.:.||..|...|..
  Fly    16 TCRLCHHNTDPNSLNIFDDTVQFCKDVSIAEVSKSLWSVQY----DRNECLSELICSRCLEILEE 76

  Fly    70 AYQFREKALRKQMEIEEYCREL---------GL-------LDESDVMMIKEEDGSQQQCDEEMYI 118
            |::.|:....::..::|..:|:         ||       :.|...::::.:..:..:..||.:.
  Fly    77 AFELRKGMQEREQSLQEQLKEMIKDHPKHRPGLNGNPGVFVPEEGCIIVEVDPENLAESSEEEFA 141

  Fly   119 LEETTTGEEEHQEEKGHEEYLEVDTSDQQECIGDTIEYLEDNYTIEMNSDQTEIVLESEKQYEET 183
            |  .:.||.|:.::...||..:.|..|:::               ..|.:..::.|..:
  Fly   142 L--GSDGEYENYDDDDEEEEEDYDEEDEED---------------GQNGEDVDMPLGMD------ 183

  Fly   184 PSQQLALQEAAKASLKARRGRVRRGLNSLTTSDGTEKGGYICDVCGNFYEKRGRMMEHR-RRHDG 247
                 |.|.||:.|:          .|:..|::...|..::|..|...:.......||. ..||.
  Fly   184 -----AAQMAAQQSV----------ANNANTTEARPKRAFLCQYCDLGFTLPAECQEHELAAHDP 233

  Fly   248 ICQYACELCDAKFQVREQLRKHMYS-HTGSKPYKCSFCSRQFFYESVLKSHENVHRGIKPYVCKV 311
            ...|.|..|:.|...|..|..|:.: |...:||.|:.|.:.|...|.||.|..||.|::|:.|.|
  Fly   234 NAPYCCNFCNIKLVTRPALISHIKTLHDPDRPYVCAHCRKGFVRRSDLKKHTIVHTGVRPFTCNV 298

  Fly   312 CDKAFAYAHSLTKHELIHSDIKLYRCDYCNKDFR----LLHHMRQHEETKLHQ 360
            |.|:|:...:||||..|||.:|.:.|..|.:.|:    ::.|.|.|.|.|..|
  Fly   299 CSKSFSRNTNLTKHMRIHSGVKPFVCQQCPRSFQTAVEMMRHTRSHGEVKAFQ 351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zif	NP_001189188.1	zf-AD	9..87	CDD:285071	20/81 (25%)
		C2H2 Zn finger	225..245	CDD:275368	4/20 (20%)
		COG5048	<250..369	CDD:227381	43/116 (37%)
		C2H2 Zn finger	253..273	CDD:275368	6/20 (30%)
		zf-H2C2_2	266..288	CDD:290200	7/22 (32%)
		C2H2 Zn finger	281..301	CDD:275368	7/19 (37%)
		zf-H2C2_2	294..318	CDD:290200	12/23 (52%)
		C2H2 Zn finger	309..329	CDD:275368	9/19 (47%)
		C2H2 Zn finger	337..353	CDD:275368	5/19 (26%)
prg	NP_001260253.1	zf-AD	16..94	CDD:285071	20/81 (25%)
		COG5048	<212..340	CDD:227381	42/127 (33%)
		C2H2 Zn finger	239..260	CDD:275368	6/20 (30%)
		C2H2 Zn finger	268..288	CDD:275368	7/19 (37%)
		zf-H2C2_2	280..305	CDD:290200	12/24 (50%)
		zf-C2H2	294..316	CDD:278523	9/21 (43%)
		C2H2 Zn finger	296..316	CDD:275368	9/19 (47%)
		zf-H2C2_2	308..331	CDD:290200	10/22 (45%)
		C2H2 Zn finger	324..344	CDD:275368	5/19 (26%)
		C2H2 Zn finger	352..372	CDD:275368	94/378 (25%)
		C2H2 Zn finger	416..436	CDD:275368
		C2H2 Zn finger	443..464	CDD:275368
		C2H2 Zn finger	470..490	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45439353
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840