DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zif and CG15436

DIOPT Version :9

Sequence 1:	NP_001189188.1	Gene:	Zif / 40795	FlyBaseID:	FBgn0037446	Length:	388	Species:	Drosophila melanogaster
Sequence 2:	NP_608840.1	Gene:	CG15436 / 33657	FlyBaseID:	FBgn0031610	Length:	346	Species:	Drosophila melanogaster

Alignment Length:	355	Identity:	83/355 - (23%)
Similarity:	129/355 - (36%)	Gaps:	106/355 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 QTCRVCLAQSERLQRLDEIREEGEESPNEMLIQLLG--VSYSNLNDREHIPDGICKSCKVELNMA 70
            :.||||:..|.:|..:.:.|.....|..||:.|..|  |...:|     ..:.||..|..::..|
  Fly     3 EICRVCMDISGKLVNIFDARRRTRVSIAEMIAQCTGFEVKRGDL-----FSEMICPQCYEDVKSA 62

  Fly    71 YQFREKALRKQMEIEEYCRELGLLDESDVMMIKEEDGSQQQCDEEMYILEETTTGEEEHQEEKGH 135
            |                                   |.:|.|:|                   .|
  Fly    63 Y-----------------------------------GIRQTCEE-------------------SH 73

  Fly   136 EEYLEVDTSDQQECIGDTIEYLEDNYTIEMNSDQTEIVLESEKQYEETPSQQLALQEAAKASLKA 200
            :.|..|    :.|.|.|.:                 ..|..|:.:|.:..:...:..|:.|.
  Fly    74 QFYCRV----RDEGIEDAL-----------------CALLEEEDWEISEDEDARIDSASAAD--- 114

  Fly   201 RRGRVRRGLNSLTTSDG---TEKGGYICDVCGNFYEKRGRMMEHRRRHDGICQYACELCDAKFQV 262
                          .||   ::|..:.|..|...|:::|..:.|.|.|.....:.|..|...|::
  Fly   115 --------------DDGKSDSKKVAFECRECHKKYQRKGTFLRHMRTHMDGQSFPCPYCKRNFRL 165

  Fly   263 REQLRKHMYSHTGSKPYKCSFCSRQFFYESVLKSHENVHRGIKPYVCKVCDKAFAYAHSLTKHEL 327
            |..|:.||.:|..:|||:||.|::.|..:|.|:|||..|.|.:|:.|..|.|.|..:..|.:|..
  Fly   166 RVTLKAHMKTHNAAKPYECSHCAKTFAQQSTLQSHERTHTGERPFKCSQCSKTFIKSSDLRRHIR 230

  Fly   328 IHSDIKLYRCDYCNKDF-RLLH---HMRQH 353
            .|...:.::|..|.|.| |..|   |.|.|
  Fly   231 THGSERPFKCSKCTKTFTRKFHLDNHFRSH 260

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zif	NP_001189188.1	zf-AD	9..87	CDD:285071	19/79 (24%)
		C2H2 Zn finger	225..245	CDD:275368	6/19 (32%)
		COG5048	<250..369	CDD:227381	39/108 (36%)
		C2H2 Zn finger	253..273	CDD:275368	7/19 (37%)
		zf-H2C2_2	266..288	CDD:290200	10/21 (48%)
		C2H2 Zn finger	281..301	CDD:275368	9/19 (47%)
		zf-H2C2_2	294..318	CDD:290200	11/23 (48%)
		C2H2 Zn finger	309..329	CDD:275368	6/19 (32%)
		C2H2 Zn finger	337..353	CDD:275368	8/19 (42%)
CG15436	NP_608840.1	zf-AD	4..78	CDD:285071	25/132 (19%)
		C2H2 Zn finger	128..148	CDD:275368	6/19 (32%)
		C2H2 Zn finger	156..176	CDD:275368	7/19 (37%)
		COG5048	<180..341	CDD:227381	31/81 (38%)
		C2H2 Zn finger	184..204	CDD:275368	9/19 (47%)
		zf-H2C2_2	197..219	CDD:290200	10/21 (48%)
		C2H2 Zn finger	212..232	CDD:275368	6/19 (32%)
		zf-H2C2_2	224..249	CDD:290200	7/24 (29%)
		C2H2 Zn finger	240..260	CDD:275368	8/19 (42%)
		zf-H2C2_2	252..276	CDD:290200	4/9 (44%)
		C2H2 Zn finger	268..288	CDD:275368
		C2H2 Zn finger	296..316	CDD:275368
		C2H2 Zn finger	324..341	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	84	1.000	Inparanoid score	I1804
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.960