DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zif and Zfp287

DIOPT Version :9

Sequence 1:	NP_001189188.1	Gene:	Zif / 40795	FlyBaseID:	FBgn0037446	Length:	388	Species:	Drosophila melanogaster
Sequence 2:	NP_001100478.1	Gene:	Zfp287 / 303212	RGDID:	1308617	Length:	762	Species:	Rattus norvegicus

Alignment Length:	383	Identity:	100/383 - (26%)
Similarity:	146/383 - (38%)	Gaps:	105/383 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 EKALRKQMEIEEYCR--ELGL---------LDESDVMMIKE------------------------ 104
            ||.|.|.:.::.|..  .|||         :.|...|:|||
  Rat   189 EKELYKTVTLQNYWNMVSLGLTVYRPTVIPILEEPWMVIKEIVEGPSPEWETKAQACSPLKDFPK 253

  Fly   105 -----------------EDGSQQQ---------CDEEMYILEETTTGEEEHQE------------ 131
                             |||.::|         .||:.:.|:...:.|:..:|
  Rat   254 LKQDGTQTIKLEESCDCEDGLERQPAYAFRKIHIDEDDFSLKSELSQEDPTEECLSKYDLYRDNF 318

  Fly   132 EKGHEEYLEVDTSDQQECIGDTIEYLEDNYTIEMNSDQTEI---VLESEKQYEETPSQQLALQEA 193
            ||.....::.||....:    |:.|.|...|....|....:   :|..:|.|    |..:..::.
  Rat   319 EKHTNLIIQFDTQSDSK----TLLYNESKPTFTNVSSGGVVHGKILPGDKPY----SCNVCGKKF 375

  Fly   194 AK-ASLKARR--------------GRVRRGLNSLTTSDGTEKG--GYICDVCGNFYEKRGRMMEH 241
            .| .||.|.|              |:..:.|:||........|  .|.|..||..:.:|..:..|
  Rat   376 RKYPSLLAHRNNHAKDKSYECEECGKEFKHLSSLIAHQRMHTGEKPYECHQCGKAFSQRAHLTIH 440

  Fly   242 RRRHDGICQYACELCDAKFQVREQLRKHMYSHTGSKPYKCSFCSRQFFYESVLKSHENVHRGIKP 306
            :|.|.|...|.|..|...|..|..|..|..:|||.|||||..||:.|.:.|.|.:|:.||.|.||
  Rat   441 QRIHTGEKPYKCNDCGKDFSQRAHLTIHQRTHTGEKPYKCLECSKTFSHSSSLINHQRVHTGEKP 505

  Fly   307 YVCKVCDKAFAYAHSLTKHELIHSDIKLYRCDYCNKDFR----LLHHMRQHEETKLHQ 360
            |:|..|.|.|:.:..|.:|:.||:..|.|:|:.|.|.|.    |:.|.|.|...|.::
  Rat   506 YICNECGKTFSQSTHLLQHQKIHTGKKPYKCNECWKVFSQSTYLIRHQRIHSGEKCYK 563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zif	NP_001189188.1	zf-AD	9..87	CDD:285071	4/11 (36%)
		C2H2 Zn finger	225..245	CDD:275368	6/19 (32%)
		COG5048	<250..369	CDD:227381	46/115 (40%)
		C2H2 Zn finger	253..273	CDD:275368	6/19 (32%)
		zf-H2C2_2	266..288	CDD:290200	12/21 (57%)
		C2H2 Zn finger	281..301	CDD:275368	7/19 (37%)
		zf-H2C2_2	294..318	CDD:290200	12/23 (52%)
		C2H2 Zn finger	309..329	CDD:275368	6/19 (32%)
		C2H2 Zn finger	337..353	CDD:275368	7/19 (37%)
Zfp287	NP_001100478.1	SCAN	46..133	CDD:280241
		KRAB	168..225	CDD:214630	9/35 (26%)
		KRAB	168..207	CDD:279668	5/17 (29%)
		C2H2 Zn finger	368..388	CDD:275368	5/19 (26%)
		zf-C2H2	394..416	CDD:278523	4/21 (19%)
		C2H2 Zn finger	396..416	CDD:275368	4/19 (21%)
		zf-H2C2_2	408..433	CDD:290200	7/24 (29%)
		COG5048	420..752	CDD:227381	55/144 (38%)
		C2H2 Zn finger	424..444	CDD:275368	6/19 (32%)
		zf-H2C2_2	436..461	CDD:290200	8/24 (33%)
		C2H2 Zn finger	452..472	CDD:275368	6/19 (32%)
		zf-H2C2_2	464..489	CDD:290200	13/24 (54%)
		C2H2 Zn finger	480..500	CDD:275368	7/19 (37%)
		zf-H2C2_2	492..517	CDD:290200	12/24 (50%)
		C2H2 Zn finger	508..528	CDD:275368	6/19 (32%)
		zf-H2C2_2	520..545	CDD:290200	10/24 (42%)
		C2H2 Zn finger	536..556	CDD:275368	7/19 (37%)
		zf-H2C2_2	548..573	CDD:290200	5/16 (31%)
		C2H2 Zn finger	564..584	CDD:275368	100/383 (26%)
		zf-C2H2	590..612	CDD:278523
		C2H2 Zn finger	592..612	CDD:275368
		zf-H2C2_2	604..629	CDD:290200
		C2H2 Zn finger	620..640	CDD:275368
		zf-H2C2_2	632..657	CDD:290200
		C2H2 Zn finger	648..668	CDD:275368
		zf-H2C2_2	660..685	CDD:290200
		C2H2 Zn finger	676..696	CDD:275368
		zf-H2C2_2	688..713	CDD:290200
		C2H2 Zn finger	704..724	CDD:275368
		zf-H2C2_2	717..741	CDD:290200
		C2H2 Zn finger	732..752	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000