DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zif and ace2

DIOPT Version :9

Sequence 1:	NP_001189188.1	Gene:	Zif / 40795	FlyBaseID:	FBgn0037446	Length:	388	Species:	Drosophila melanogaster
Sequence 2:	NP_594109.1	Gene:	ace2 / 2541661	PomBaseID:	SPAC6G10.12c	Length:	533	Species:	Schizosaccharomyces pombe

Alignment Length:	318	Identity:	60/318 - (18%)
Similarity:	108/318 - (33%)	Gaps:	98/318 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 SPNEMLIQL-----------LGVSYSNLNDREHIPDGICKSCKVELNMAYQFREKALRKQMEIEE 86
            ||...|::|           |..|:|:|:        :|:         :...:||..|.....|
pombe   276 SPFAQLVKLEPTSPQKPSFALDSSFSHLD--------VCR---------HTDNQKAFAKLSSPAE 323

  Fly    87 YCRELGLLDESDVMMIKEEDGSQQQCDEEMYI----LEETTTGEEEHQEEKGHEEYLEVDTSDQQ 147
            |              :.|.:.....||..:.|    :..|.|  ::......:|..  :.|...:
pombe   324 Y--------------VSEFEKFSSVCDHGLDISNANINNTLT--QQFALSAPYESC--IVTKKPE 370

  Fly   148 ECIGDTIEYLEDNYTIEMNSDQTEIVLESEKQYEETPSQQLALQEAAKASLKARRGRVRRGLNSL 212
            .||  |::. |:....::.|....|. ....:::..|..:::.....|...::.|
pombe   371 PCI--TVKE-EEQLAPKIESADLSIT-PQVTEHDSKPPVRISYDHRCKTRKQSTR---------- 421

  Fly   213 TTSDGTEKGGYICDV---------CGNFYEKRGRMMEHRRRHDGICQYACELCDAKFQVREQLRK 268
                       ||.:         ||.  |..|:.         :|.|  ..|:.:...:..:..
pombe   422 -----------ICRIPPETMASLYCGP--EADGKY---------VCLY--NGCNKRIARKYNVES 462

  Fly   269 HMYSHTGSKPYKCSFCSRQFFYESVLKSHENVHRGIKPYVCKVCDKAFAYAHSLTKHE 326
            |:.:|...:||:|..|...|.....||.|..:|...:||||: |.|.|....:|.:|:
pombe   463 HIQTHLSDRPYRCDLCKAGFVRHHDLKRHLRIHENGRPYVCE-CLKRFNRLDALNRHK 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zif	NP_001189188.1	zf-AD	9..87	CDD:285071	12/64 (19%)
		C2H2 Zn finger	225..245	CDD:275368	5/28 (18%)
		COG5048	<250..369	CDD:227381	22/77 (29%)
		C2H2 Zn finger	253..273	CDD:275368	2/19 (11%)
		zf-H2C2_2	266..288	CDD:290200	6/21 (29%)
		C2H2 Zn finger	281..301	CDD:275368	6/19 (32%)
		zf-H2C2_2	294..318	CDD:290200	11/23 (48%)
		C2H2 Zn finger	309..329	CDD:275368	6/18 (33%)
		C2H2 Zn finger	337..353	CDD:275368
ace2	NP_594109.1	COG5048	45..518	CDD:227381	59/315 (19%)
		C2H2 Zn finger	448..467	CDD:275368	2/18 (11%)
		zf-C2H2	473..495	CDD:278523	7/21 (33%)
		C2H2 Zn finger	475..495	CDD:275368	6/19 (32%)
		zf-H2C2_2	487..511	CDD:290200	11/24 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	84	1.000	Inparanoid score	I1804
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050