DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Zif and ZNF627

DIOPT Version :10

Sequence 1:NP_649657.1 Gene:Zif / 40795 FlyBaseID:FBgn0037446 Length:388 Species:Drosophila melanogaster
Sequence 2:NP_660338.1 Gene:ZNF627 / 199692 HGNCID:30570 Length:461 Species:Homo sapiens


Alignment Length:401 Identity:95/401 - (23%)
Similarity:143/401 - (35%) Gaps:121/401 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 QRLDEIRE--EGEESPNEMLIQLLGVSYSNLNDREHIPDGI-------CKSCKVEL--------- 67
            :||.|.:|  :|||:.::                  |||||       .|.|:..:         
Human    68 ERLCESKEGGQGEETFSQ------------------IPDGILNKKTPGVKPCESSVCGEVGMGPS 114

  Fly    68 NMAYQFREKALRKQMEIEEY----------------------------------CRELGLLDESD 98
            ::....|:...|:..|.:||                                  |:|.|....|.
Human   115 SLNRHIRDHTGREPNEYQEYGKKSYTRNQCGRALSYHRSFPVRERTHPGGKPYDCKECGETFISL 179

  Fly    99 VM----MIKEEDGSQQQC---------DEEMYILEETTTGEEEHQEEKGHEEYLEVDTSDQQECI 150
            |.    |:....|...:|         .....|.|.:.|||:.::.::..:.:         .| 
Human   180 VSIRRHMLTHRGGVPYKCKVCGKAFDYPSLFRIHERSHTGEKPYECKQCGKAF---------SC- 234

  Fly   151 GDTIEYLEDNYTIEMNSDQTEIVLESEKQYEETPSQQLALQEAAKASLKARRGRVRRGLNSLTTS 215
            ...|...|..:|             .:|.||        .::..||...::..|:....:     
Human   235 SSYIRIHERTHT-------------GDKPYE--------CKQCGKAFSCSKYIRIHERTH----- 273

  Fly   216 DGTEKGGYICDVCGNFYEKRGRMMEHRRRHDGICQYACELCDAKFQVREQLRKHMYSHTGSKPYK 280
              |.:..|.|..||..:.....:..|.|.|.|...:.|:.|.........:|:||..|||:.|||
Human   274 --TGEKPYECKQCGKAFRCASSVRSHERTHTGEKLFECKECGKALTCLASVRRHMIKHTGNGPYK 336

  Fly   281 CSFCSRQFFYESVLKSHENVHRGIKPYVCKVCDKAFAYAHSLTKHELIHSDIKLYRCDYCNKDFR 345
            |..|.:.|.:.|..:.||..|.|.|||.||.|.|||:.:.|..|||.||:..|.|:|..|.|.|.
Human   337 CKVCGKAFDFPSSFRIHERTHTGEKPYDCKQCGKAFSCSSSFRKHERIHTGEKPYKCTKCGKAFS 401

  Fly   346 LLHHMRQHEET 356
            ...:.|.||.|
Human   402 RSSYFRIHERT 412

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ZifNP_649657.1 zf-AD 9..87 CDD:462262 17/83 (20%)
C2H2 Zn finger 225..245 CDD:275368 5/19 (26%)
COG5048 <250..369 CDD:227381 44/107 (41%)
C2H2 Zn finger 253..273 CDD:275368 5/19 (26%)
C2H2 Zn finger 281..301 CDD:275368 6/19 (32%)
C2H2 Zn finger 309..329 CDD:275368 10/19 (53%)
C2H2 Zn finger 337..353 CDD:275368 5/15 (33%)
ZNF627NP_660338.1 KRAB 3..44 CDD:460171
C2H2 Zn finger 142..161 CDD:275368 0/18 (0%)
C2H2 Zn finger 169..189 CDD:275368 6/19 (32%)
COG5048 <174..382 CDD:227381 59/245 (24%)
C2H2 Zn finger 197..217 CDD:275368 3/19 (16%)
C2H2 Zn finger 225..245 CDD:275368 3/29 (10%)
C2H2 Zn finger 253..273 CDD:275368 3/19 (16%)
C2H2 Zn finger 281..301 CDD:275368 5/19 (26%)
C2H2 Zn finger 309..329 CDD:275368 5/19 (26%)
C2H2 Zn finger 337..357 CDD:275368 6/19 (32%)
C2H2 Zn finger 365..385 CDD:275368 10/19 (53%)
zf-H2C2_2 377..402 CDD:463886 12/24 (50%)
C2H2 Zn finger 393..413 CDD:275368 8/20 (40%)
zf-H2C2_2 405..430 CDD:463886 4/8 (50%)
C2H2 Zn finger 421..441 CDD:275368
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.