DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zif and ZNF675

DIOPT Version :9

Sequence 1:	NP_001189188.1	Gene:	Zif / 40795	FlyBaseID:	FBgn0037446	Length:	388	Species:	Drosophila melanogaster
Sequence 2:	NP_612203.2	Gene:	ZNF675 / 171392	HGNCID:	30768	Length:	568	Species:	Homo sapiens

Alignment Length:	404	Identity:	97/404 - (24%)
Similarity:	161/404 - (39%)	Gaps:	117/404 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 VSYSNLNDREHIPDGICK--SCKVELNMA---------------YQFRE--KALRKQMEIEEY-- 87
            :|:...::|.:.....||  .|:..:|.:               |:.:|  :...:...:.||
Human   184 LSHLTRHERNYTKVNFCKCEECEKAVNQSSKLTKHKRIYTCEKLYKCQECDRTFNQFSNLTEYKK 248

  Fly    88 ---------CRELGL-------LDESDVMMIKEEDGSQQQC------------------DEEMYI 118
                     |.|.|.       |....::...|:....::|                  .|:.||
Human   249 DYAREKPYKCEECGKAFNQSSHLTTHKIIHTGEKPYKCEECGKAFNQFSNLTTHKKIHTGEQPYI 313

  Fly   119 LEE-----------TT-----TGEEEHQ-EEKGH--------EEYLEVDTSDQ----QECIGDTI 154
            .||           ||     |||:.:: ||.|.        .|:..:.|.:|    :||
Human   314 CEECGKAFTQSSTLTTHKRIHTGEKPYKCEECGKAFNRSSKLTEHKNIHTGEQPYKCEEC----- 373

  Fly   155 EYLEDNYTIEMNSDQTE--IVLESEKQYEETPSQQLALQEAAKASLKARRGRVRRGLNSLTTSDG 217
                 ......:|:.||  .:...||.|:        .:|..||.         :..::|||...
Human   374 -----GKAFNRSSNLTEHRKIHTEEKPYK--------CKECGKAF---------KHSSALTTHKR 416

  Fly   218 TEKG--GYICDVCGNFYEKRGRMMEHRRRHDGICQYACELCDAKFQVREQLRKHMYSHTGSKPYK 280
            ...|  .|.|:.||..:.:..::.||::.|.|...|.||.|...|....:|.:|...|:|..|||
Human   417 IHTGEKPYKCEECGKAFNRSSKLTEHKKLHTGKKPYKCEECGKAFIQSSKLTEHKKIHSGEIPYK 481

  Fly   281 CSFCSRQFFYESVLKSHENVHRGIKPYVCKVCDKAFAYAHSLTKHELIHSDIKLYRCDYCNKDFR 345
            |..|.:.|.:.|.|.:|:.:|.|.|||.|:.|.|||:.:..||:|::||:..|.|:|:.|:|.|.
Human   482 CEECGKAFKHSSSLTTHKRIHTGEKPYKCEECGKAFSRSSKLTEHKIIHTGEKPYKCERCDKAFN 546

  Fly   346 LLHHMRQHEETKLH 359
            ...::.:|:  |:|
Human   547 QSANLTKHK--KIH 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zif	NP_001189188.1	zf-AD	9..87	CDD:285071	8/61 (13%)
		C2H2 Zn finger	225..245	CDD:275368	5/19 (26%)
		COG5048	<250..369	CDD:227381	42/110 (38%)
		C2H2 Zn finger	253..273	CDD:275368	6/19 (32%)
		zf-H2C2_2	266..288	CDD:290200	9/21 (43%)
		C2H2 Zn finger	281..301	CDD:275368	6/19 (32%)
		zf-H2C2_2	294..318	CDD:290200	12/23 (52%)
		C2H2 Zn finger	309..329	CDD:275368	8/19 (42%)
		C2H2 Zn finger	337..353	CDD:275368	4/15 (27%)
ZNF675	NP_612203.2	KRAB	4..62	CDD:214630
		KRAB	4..43	CDD:279668
		COG5048	169..556	CDD:227381	95/400 (24%)
		C2H2 Zn finger	174..194	CDD:275370	2/9 (22%)
		C2H2 Zn finger	202..222	CDD:275368	2/19 (11%)
		C2H2 Zn finger	230..250	CDD:275368	3/19 (16%)
		C2H2 Zn finger	258..278	CDD:275368	4/19 (21%)
		zf-H2C2_2	270..295	CDD:290200	3/24 (13%)
		C2H2 Zn finger	286..306	CDD:275368	1/19 (5%)
		C2H2 Zn finger	314..334	CDD:275368	4/19 (21%)
		zf-H2C2_2	327..351	CDD:290200	8/23 (35%)
		C2H2 Zn finger	342..362	CDD:275368	4/19 (21%)
		C2H2 Zn finger	370..390	CDD:275368	5/29 (17%)
		zf-H2C2_2	382..407	CDD:290200	8/41 (20%)
		C2H2 Zn finger	398..418	CDD:275368	6/28 (21%)
		zf-H2C2_2	410..435	CDD:290200	8/24 (33%)
		C2H2 Zn finger	426..446	CDD:275368	5/19 (26%)
		C2H2 Zn finger	454..474	CDD:275368	6/19 (32%)
		C2H2 Zn finger	482..502	CDD:275368	6/19 (32%)
		zf-H2C2_2	494..519	CDD:290200	12/24 (50%)
		C2H2 Zn finger	510..530	CDD:275368	8/19 (42%)
		C2H2 Zn finger	538..558	CDD:275368	6/21 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000